His primary scientific interests are in Cancer research, Biochemistry, Pharmacology, Structure–activity relationship and PKM2. His Cancer research research includes themes of Diffuse large B-cell lymphoma, Signal transduction, breakpoint cluster region, B-cell receptor and Bruton's tyrosine kinase. His work on Small molecule, Enzyme, Thioredoxin and Chinese hamster ovary cell as part of general Biochemistry study is frequently connected to Peroxiredoxin, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His Drug study, which is part of a larger body of work in Pharmacology, is frequently linked to Esketamine, bridging the gap between disciplines. His biological study spans a wide range of topics, including Camptothecin, DNA, Beta-Lactamase Inhibitors, DNA Topoisomerase I and High-throughput screening. He has included themes like Cancer cell, Enzyme activator and Pyruvate decarboxylation in his PKM2 study.
Craig J. Thomas focuses on Cancer research, Pharmacology, Biochemistry, Stereochemistry and Kinase. The various areas that he examines in his Cancer research study include Cancer cell, Cancer, Carcinogenesis, Cell growth and PI3K/AKT/mTOR pathway. His work in Pharmacology addresses issues such as Ketamine, which are connected to fields such as Hydroxynorketamine.
His studies in Structure–activity relationship, Pyruvate kinase, Small molecule, PKM2 and Enzyme are all subfields of Biochemistry research. His Pyruvate kinase research is multidisciplinary, relying on both Phosphoenolpyruvate carboxykinase and Cell biology. His study looks at the relationship between Stereochemistry and topics such as Receptor, which overlap with Endocrinology.
Craig J. Thomas mostly deals with Cancer research, Kinase, In vivo, Pyruvate kinase and Pharmacology. Craig J. Thomas interconnects Cell culture, Protein kinase B, Cell growth, Transcription factor and PI3K/AKT/mTOR pathway in the investigation of issues within Cancer research. His work on LYN as part of his general Kinase study is frequently connected to Cell Migration Assay, thereby bridging the divide between different branches of science.
His studies in In vivo integrate themes in fields like Sickle cell trait, Chronic pain, Renal cell carcinoma, Docetaxel and Hippocampus. His Pyruvate kinase research is multidisciplinary, incorporating elements of PCK2 and Phosphoenolpyruvate carboxykinase. His Pharmacology study combines topics in areas such as Antidepressant, Monoclonal antibody, Mood disorders and Ketamine.
Craig J. Thomas spends much of his time researching Cancer research, Cell biology, Pyruvate kinase, Phosphoenolpyruvate carboxykinase and Kinase. The study incorporates disciplines such as Viability assay, Malignant peripheral nerve sheath tumor and Cell growth in addition to Cancer research. His study in Cell biology is interdisciplinary in nature, drawing from both Glycolysis, Metabolism, Oxidative phosphorylation and RNA-Seq.
His work deals with themes such as Allosteric regulation and Proto-oncogene tyrosine-protein kinase Src, which intersect with Glycolysis. His Pyruvate kinase research incorporates elements of Insulin and Pancreatic islets. Craig J. Thomas combines subjects such as Phenotype, Computational biology and Orders of magnitude with his study of Kinase.
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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
R. Eric Davis;Vu N. Ngo;Georg Lenz;Pavel Tolar.
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
Dimitrios Anastasiou;Dimitrios Anastasiou;George Poulogiannis;George Poulogiannis;John M. Asara;John M. Asara;Matthew B. Boxer.
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Panos Zanos;Ruin Moaddel;Patrick J. Morris;Polymnia Georgiou.
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
Eva M. Palsson-McDermott;Anne M. Curtis;Gautam Goel;Gautam Goel;Mario A.R. Lauterbach.
Cell Metabolism (2015)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Dimitrios Anastasiou;Yimin Yu;William James Israelsen;Jian-Kang Jiang.
Nature Chemical Biology (2012)
Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)
Kamran Ghoreschi;Michael I. Jesson;Xiong Li;Jamie L. Lee.
Journal of Immunology (2011)
Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma
Yibin Yang;Arthur L. Shaffer;N.C. Tolga Emre;Michele Ceribelli.
Cancer Cell (2012)
Camptothecin: current perspectives.
Craig J. Thomas;Nicolas J. Rahier;Sidney M. Hecht.
Bioorganic & Medicinal Chemistry (2004)
Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice
Tammy M. Holm;Jennifer P. Habashi;Jefferson J. Doyle;Djahida Bedja.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
Lesley A. Mathews Griner;Rajarshi Guha;Paul Shinn;Ryan M. Young.
Proceedings of the National Academy of Sciences of the United States of America (2014)
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