World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
22286
World Ranking
5269
National Ranking
2505

Overview

James Inglese is affiliated with the National Institutes of Health in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, immunology, aging, oncology, and spectroscopy. Inglese's work covers a wide range of topics such as genetics, aging, and longevity in model organisms, ubiquitin and proteasome pathways, computational drug discovery methods, RNA and protein synthesis mechanisms, metabolomics and mass spectrometry studies, Hedgehog signaling pathway studies, and biochemical and molecular research.

Inglese's publication record shows contributions to a variety of respected scientific journals and platforms. Frequent venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The FASEB Journal
  • Journal of Pharmacology and Experimental Therapeutics
  • ACS Chemical Biology
  • PLoS ONE

Some recent papers authored or co-authored by Inglese include:

  • Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases, 2022, ACS Chemical Biology
  • A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology, 2020, PLoS ONE
  • High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle, 2020, ACS Chemical Biology
  • In vivo quantitative high-throughput screening for drug discovery and comparative toxicology, 2023, Disease Models & Mechanisms
  • Methotrexate-based PROTACs as DHFR-specific chemical probes, 2023, Cell chemical biology

Inglese has collaborated frequently with a number of researchers throughout their career. Some of the most frequent co-authors include:

  • Patricia Dranchak
  • Ganesha Rai
  • Bryan Queme
  • Erin Oliphant
  • Amy E. Moritz

The scientist's body of work integrates extensive studies in molecular pathways and mechanisms, employing high-throughput screening and biochemical methods to explore protein interactions and drug discovery possibilities. This multidisciplinary approach is evident in both the diversity of topics addressed and the range of publication venues where Inglese's research appears.

Best Publications

  • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

    Julie A. Pitcher;James Inglese;Joyce B. Higgins;Jeffery L. Arriza

  • Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

    James Inglese;Douglas S. Auld;Ajit Jadhav;Ronald L. Johnson

  • Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

    Dimitrios Anastasiou;Yimin Yu;William James Israelsen;Jian-Kang Jiang

  • High-throughput screening assays for the identification of chemical probes

    James Inglese;Ronald L Johnson;Anton Simeonov;Menghang Xia

  • Protein kinases that phosphorylate activated G protein-coupled receptors.

    Richard T. Premont;James Inglese;Robert J. Lefkowitz

  • Binding of G protein beta gamma-subunits to pleckstrin homology domains.

    K Touhara;J Inglese;J A Pitcher;G Shaw

  • Structure and mechanism of the G protein-coupled receptor kinases.

    J Inglese;N J Freedman;W J Koch;R J Lefkowitz

  • Activation of the cloned muscarinic potassium channel by G protein βγ subunits

    Eitan Reuveny;Paul A. Slesinger;James Inglese;Janine M. Morales

  • The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

    W.J. Koch;J. Inglese;W.C. Stone;R.J. Lefkowitz

  • Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

    W.J. Koch;B.E. Hawes;J. Inglese;L.M. Luttrell

  • Apparent Activity in High-Throughput Screening: Origins of Compound-Dependent Assay Interference

    Natasha Thorne;Douglas S Auld;James Inglese

  • A high-throughput screen for aggregation-based inhibition in a large compound library.

    Brian Y. Feng;Anton Simeonov;Ajit Jadhav;Kerim Babaoglu

  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.

    James Inglese;Walter J. Koch;Marc G. Caron;Robert J. Lefkowitz

  • Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase *

    Ching Kang Chen;James Inglese;Robert J. Lefkowitz;James B. Hurley

  • Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology

    Natasha Thorne;James Inglese;Douglas S. Auld

  • A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits

    Jianqiang Chen;Michael DeVivo;Jane Dingus;Anya Harry

  • Identification of oxadiazoles as new drug leads for the control of schistosomiasis

    Ahmed A Sayed;Anton Simeonov;Craig J Thomas;James Inglese

  • Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

    Douglas S. Auld;Natasha Thorne;William F. Maguire;James Inglese

  • Compound cytotoxicity profiling using quantitative high-throughput screening.

    Menghang Xia;Ruili Huang;Kristine L. Witt;Noel Southall

  • Assay Guidance Manual

    G. Sitta Sittampalam;Nathan P. Coussens;Henrike Nelson;Michelle Arkin

Frequent Co-Authors

Christopher P. Austin
Christopher P. Austin National Institutes of Health
Anton Simeonov
Anton Simeonov National Institutes of Health
Ajit Jadhav
Ajit Jadhav Pfizer (Germany)
Craig J. Thomas
Craig J. Thomas National Institutes of Health
Ruili Huang
Ruili Huang National Institutes of Health
Wei Zheng
Wei Zheng National Institutes of Health
Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Menghang Xia
Menghang Xia National Institutes of Health
Walter J. Koch
Walter J. Koch Temple University
Rajarshi Guha
Rajarshi Guha Google (United States)

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