What is he best known for?
The fields of study he is best known for:
His scientific interests lie mostly in Biochemistry, High-throughput screening, G protein-coupled receptor kinase, G protein and Drug discovery.
James Inglese interconnects Biological activity, Structure–activity relationship and Enzyme in the investigation of issues within High-throughput screening.
His G protein-coupled receptor kinase study which covers Protein kinase A that intersects with Protein prenylation and Cell surface receptor.
In G protein, he works on issues like G alpha subunit, which are connected to Binding domain.
His Drug discovery study integrates concerns from other disciplines, such as Combinatorial chemistry and Computational biology.
His research in Luciferase intersects with topics in Molecular biology and Bioluminescence.
His most cited work include:
- Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. (628 citations)
- Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. (623 citations)
- Protein kinases that phosphorylate activated G protein-coupled receptors. (466 citations)
What are the main themes of his work throughout his whole career to date?
James Inglese mainly investigates Biochemistry, High-throughput screening, Cell biology, Molecular biology and Small molecule.
His study in Enzyme, Luciferase, Structure–activity relationship, G protein-coupled receptor kinase and Kinase are all subfields of Biochemistry.
The various areas that James Inglese examines in his G protein-coupled receptor kinase study include Mitogen-activated protein kinase kinase and Beta adrenergic receptor kinase.
His High-throughput screening research integrates issues from Receptor, Antibody, Computational biology and Drug discovery.
His Drug discovery study combines topics in areas such as Chemical biology and Pharmacology.
His work deals with themes such as Identification and Fusion protein, which intersect with Cell biology.
He most often published in these fields:
- Biochemistry (42.93%)
- High-throughput screening (21.74%)
- Cell biology (21.20%)
What were the highlights of his more recent work (between 2014-2021)?
- Cell biology (21.20%)
- High-throughput screening (21.74%)
- Drug discovery (12.50%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Cell biology, High-throughput screening, Drug discovery, Biochemistry and Cell.
His studies examine the connections between Cell biology and genetics, as well as such issues in Nonsense-mediated decay, with regards to Exon junction complex, DNA and Messenger RNA.
His studies deal with areas such as Gs alpha subunit, Computational biology, Small molecule and Heterologous expression as well as High-throughput screening.
His Drug discovery study combines topics from a wide range of disciplines, such as Secretory protein, Quantitative proteomics and Pharmacology.
He performs integrative Biochemistry and Phosphoglycerate mutase research in his work.
His study in Cell is interdisciplinary in nature, drawing from both Neuropeptide, Nuclear localization sequence, Fusion protein and Gene isoform.
Between 2014 and 2021, his most popular works were:
- Mitigating risk in academic preclinical drug discovery (82 citations)
- High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. (64 citations)
- Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. (36 citations)
In his most recent research, the most cited papers focused on:
James Inglese mostly deals with Drug discovery, Cell biology, Pharmacology, Extramural and Gene.
His studies in Drug discovery integrate themes in fields like Orphan drug and Preclinical pharmacology.
His research in the fields of Transport protein overlaps with other disciplines such as Streptavidin.
His work on Drug development is typically connected to Institutional level as part of general Pharmacology study, connecting several disciplines of science.
His Extramural research incorporates elements of Drug resistance, Drug, Inhibitory concentration 50, Drug Antagonism and Drug synergism.
When carried out as part of a general Gene research project, his work on RNA splicing and Messenger RNA is frequently linked to work in RNA surveillance and mRNA surveillance, therefore connecting diverse disciplines of study.
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