Robert J. Lefkowitz

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United States Leader Award
• 2025 - Research.com Best Scientists Award
• 2025 - Research.com Biology and Biochemistry in United States Leader Award
• 2023 - Research.com Biology and Biochemistry in United States Leader Award
• 2022 - Research.com Biology and Biochemistry in United States Leader Award
• 2015 - Fellow, National Academy of Inventors
• 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
• 2012 - Nobel Prize for studies of G-protein-coupled receptors
• 2009 - BBVA Foundation Frontiers of Knowledge Award
• 2007 - US President's National Medal of Science "For his discovery of the seven transmembrane receptors, deemed the largest, most versatile, and most therapeutically accessible receptor signaling system, and for describing the general mechanism of their regulation, influencing all fields of medical practice.", Presented by President George W. Bush in the East Room of the White House on September 29, 2008.
• 2007 - Albany Medical Center Prize in Medicine and Biomedical Research
• 2003 - Distinguished Scientist Award, American Heart Association
• 2001 - Jessie Stevenson Kovalenko Medal, US National Academy of Sciences For his elucidation of the structure, function, and mechanism of regulation of heptahelical receptors, nature's detectors of signals from many hormones, neurotransmitters, and drugs.
• 2001 - Robert J. and Claire Pasarow Foundation Medical Research Award
• 1994 - Member of the National Academy of Medicine (NAM)
• 1988 - Canada Gairdner International Award
• 1988 - Fellow of the American Academy of Arts and Sciences
• 1988 - Member of the National Academy of Sciences
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians

Overview

Best Publications

• Seven-transmembrane receptors.

  Kristen L. Pierce;Richard T. Premont;Robert J. Lefkowitz

  3488
  Citations

• Transduction of receptor signals by beta-arrestins.

  Robert J. Lefkowitz;Sudha K. Shenoy;Sudha K. Shenoy

  2100
  Citations

• A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

  A De Lean;J M Stadel;R J Lefkowitz

  2082
  Citations

• Model systems for the study of seven-transmembrane-segment receptors.

  Henrik G. Dohlman;Jeremy Thorner;Marc G. Caron;Robert J. Lefkowitz

  1880
  Citations

• Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

  L. M. Luttrell;S. S. G. Ferguson;Y. Daaka;W. E. Miller

  1846
  Citations

• Turning off the signal: desensitization of beta-adrenergic receptor function.

  William P. Hausdorff;Marc G. Caron;Robert J. Lefkowitz

  1707
  Citations

• Cloning of the gene and cDNA for mammalian β -adrenergic receptor and homology with rhodopsin

  Richard A. F. Dixon;Brian K. Kobilka;David J. Strader;Jeffrey L. Benovic

  1699
  Citations

• β-Arrestins and Cell Signaling

  Scott M. DeWire;Seungkirl Ahn;Robert J. Lefkowitz;Sudha K. Shenoy

  1674
  Citations

• Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

  Yehia Daaka;Louis M. Luttrell;Robert J. Lefkowitz

  1628
  Citations

• G protein-coupled receptor kinases.

  Julie A. Pitcher;Neil J. Freedman;Robert J. Lefkowitz

  1622
  Citations

• International Union of Pharmacology nomenclature of adrenoceptors.

  D B Bylund;D C Eikenberg;J P Hieble;S Z Langer

  1604
  Citations

• A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

  P. Samama;S. Cotecchia;T. Costa;R.J. Lefkowitz

  1603
  Citations

• Beta-arrestin: a protein that regulates beta-adrenergic receptor function

  Martin J. Lohse;Jeffrey L. Benovic;Juan Codina;Marc G. Caron

  1515
  Citations

• The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

  Louis M. Luttrell;Robert J. Lefkowitz;Robert J. Lefkowitz

  1457
  Citations

• G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.

  Robert J. Lefkowitz

  1422
  Citations

• Seven-transmembrane-spanning receptors and heart function

  Howard A. Rockman;Walter J. Koch;Robert J. Lefkowitz

  1260
  Citations

• Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.

  Louis M. Luttrell;Francine L. Roudabush;Eric W. Choy;William E. Miller

  1197
  Citations

• An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior

  Jean-Martin Beaulieu;Tatyana D. Sotnikova;Sébastien Marion;Robert J. Lefkowitz

  1185
  Citations

• Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

  Laura M. Bohn;Robert J. Lefkowitz;Raul R. Gainetdinov;Karsten Peppel

  1179
  Citations

• Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.

  Laura M. Bohn;Raul R. Gainetdinov;Fang-Tsyr Lin;Robert J. Lefkowitz

  1074
  Citations