H-Index & Metrics Top Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry H-index 260 Citations 204,446 841 World Ranking 2 National Ranking 1

Research.com Recognitions

Awards & Achievements

2015 - Fellow, National Academy of Inventors

2013 - Fellow of the American Association for the Advancement of Science (AAAS)

2012 - Nobel Prize for studies of G-protein-coupled receptors

2009 - BBVA Foundation Frontiers of Knowledge Award

2007 - Albany Medical Center Prize in Medicine and Biomedical Research

2007 - US President's National Medal of Science "For his discovery of the seven transmembrane receptors, deemed the largest, most versatile, and most therapeutically accessible receptor signaling system, and for describing the general mechanism of their regulation, influencing all fields of medical practice.", Presented by President George W. Bush in the East Room of the White House on September 29, 2008.

2003 - Distinguished Scientist Award, American Heart Association

2001 - Jessie Stevenson Kovalenko Medal, US National Academy of Sciences For his elucidation of the structure, function, and mechanism of regulation of heptahelical receptors, nature's detectors of signals from many hormones, neurotransmitters, and drugs.

2001 - Robert J. and Claire Pasarow Foundation Medical Research Award

1994 - Member of the National Academy of Medicine (NAM)

1988 - Canada Gairdner International Award

1988 - Fellow of the American Academy of Arts and Sciences

1988 - Member of the National Academy of Sciences

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Receptor

His main research concerns Cell biology, Receptor, G protein-coupled receptor, Biochemistry and G protein-coupled receptor kinase. All of his Cell biology and Signal transduction, Beta-Arrestins, G protein, Heterotrimeric G protein and Phosphorylation investigations are sub-components of the entire Cell biology study. His Phosphorylation research is multidisciplinary, incorporating elements of Homologous desensitization and Kinase.

Receptor is a subfield of Internal medicine that Robert J. Lefkowitz studies. His work in G protein-coupled receptor addresses issues such as 5-HT5A receptor, which are connected to fields such as Enzyme-linked receptor and Tropomyosin receptor kinase C. His G protein-coupled receptor kinase research incorporates elements of Molecular biology, Rhodopsin-like receptors and Beta adrenergic receptor kinase.

His most cited work include:

  • Seven-transmembrane receptors. (2061 citations)
  • Transduction of receptor signals by beta-arrestins. (1417 citations)
  • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. (1350 citations)

What are the main themes of his work throughout his whole career to date?

Robert J. Lefkowitz mainly focuses on Receptor, Cell biology, Biochemistry, G protein-coupled receptor and Internal medicine. Robert J. Lefkowitz regularly ties together related areas like Molecular biology in his Receptor studies. His study explores the link between Cell biology and topics such as 5-HT5A receptor that cross with problems in Enzyme-linked receptor.

His work in G protein-coupled receptor addresses subjects such as G protein, which are connected to disciplines such as Biophysics. His Internal medicine research focuses on Endocrinology and how it connects with Homologous desensitization, Dihydroalprenolol and Pharmacology. Robert J. Lefkowitz combines subjects such as Rhodopsin-like receptors and Beta adrenergic receptor kinase with his study of G protein-coupled receptor kinase.

He most often published in these fields:

  • Receptor (64.60%)
  • Cell biology (42.80%)
  • Biochemistry (38.50%)

What were the highlights of his more recent work (between 2005-2021)?

  • Receptor (64.60%)
  • G protein-coupled receptor (32.30%)
  • Cell biology (42.80%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Receptor, G protein-coupled receptor, Cell biology, Arrestin and Signal transduction. As part of the same scientific family, Robert J. Lefkowitz usually focuses on Receptor, concentrating on Endocrinology and intersecting with Adrenergic receptor. G protein-coupled receptor is a subfield of Biochemistry that Robert J. Lefkowitz explores.

His study looks at the relationship between Cell biology and topics such as Internalization, which overlap with Endosome. His Signal transduction study combines topics in areas such as Angiotensin II, Pharmacology and Protein kinase A. His work deals with themes such as 5-HT5A receptor, Rhodopsin-like receptors and Beta adrenergic receptor kinase, which intersect with G protein-coupled receptor kinase.

Between 2005 and 2021, his most popular works were:

  • β-Arrestins and Cell Signaling (1132 citations)
  • Teaching old receptors new tricks: biasing seven-transmembrane receptors (651 citations)
  • Teaching old receptors new tricks: biasing seven-transmembrane receptors (651 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

Robert J. Lefkowitz mainly investigates G protein-coupled receptor, Cell biology, Beta-Arrestins, Signal transduction and Arrestin. Receptor and Biochemistry are the two main areas of interest in his G protein-coupled receptor studies. In his work, Stimulation is strongly intertwined with Ligand, which is a subfield of Receptor.

In his research, Class C GPCR, 5-HT1 receptor and Receptor tyrosine kinase is intimately related to Rhodopsin-like receptors, which falls under the overarching field of Cell biology. His research integrates issues of Angiotensin II, Internalization and Protein kinase A in his study of Signal transduction. His Arrestin study incorporates themes from GTP-binding protein regulators, G protein, Plasma protein binding and Phosphorylation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

Seven-transmembrane receptors.

Kristen L. Pierce;Richard T. Premont;Robert J. Lefkowitz.
Nature Reviews Molecular Cell Biology (2002)

3090 Citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

A De Lean;J M Stadel;R J Lefkowitz.
Journal of Biological Chemistry (1980)

1937 Citations

Transduction of receptor signals by beta-arrestins.

Robert J. Lefkowitz;Sudha K. Shenoy.
Science (2005)

1866 Citations

β-Arrestins and Cell Signaling

Scott M. DeWire;Seungkirl Ahn;Robert J. Lefkowitz;Sudha K. Shenoy.
Annual Review of Physiology (2007)

1815 Citations

Model systems for the study of seven-transmembrane-segment receptors.

Henrik G. Dohlman;Jeremy Thorner;Marc G. Caron;Robert J. Lefkowitz.
Annual Review of Biochemistry (1991)

1815 Citations

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

L. M. Luttrell;S. S. G. Ferguson;Y. Daaka;W. E. Miller.
Science (1999)

1717 Citations

Turning off the signal: desensitization of beta-adrenergic receptor function.

William P. Hausdorff;Marc G. Caron;Robert J. Lefkowitz.
The FASEB Journal (1990)

1628 Citations

Cloning of the gene and cDNA for mammalian β -adrenergic receptor and homology with rhodopsin

Richard A. F. Dixon;Brian K. Kobilka;David J. Strader;Jeffrey L. Benovic.
Nature (1986)

1604 Citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

P. Samama;S. Cotecchia;T. Costa;R.J. Lefkowitz.
Journal of Biological Chemistry (1993)

1532 Citations

G protein-coupled receptor kinases.

Julie A. Pitcher;Neil J. Freedman;Robert J. Lefkowitz.
Annual Review of Biochemistry (1998)

1511 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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