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Robert J. Lefkowitz

Robert J. Lefkowitz

Duke University
United States

Award Badge
Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
261
Citations
208499
World Ranking
35
National Ranking
23

Biology and Biochemistry

D-Index
262
Citations
210984
World Ranking
4
National Ranking
2

Robert J. Lefkowitz publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Robert J. Lefkowitz sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 936 publications — 99th percentile

99% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Robert J. Lefkowitz D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Robert J. Lefkowitz sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 262 D-Index — 100th percentile

100% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2022 - Research.com Biology and Biochemistry in United States Leader Award
  • 2015 - Fellow, National Academy of Inventors
  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2012 - Nobel Prize for studies of G-protein-coupled receptors
  • 2009 - BBVA Foundation Frontiers of Knowledge Award
  • 2007 - US President's National Medal of Science "For his discovery of the seven transmembrane receptors, deemed the largest, most versatile, and most therapeutically accessible receptor signaling system, and for describing the general mechanism of their regulation, influencing all fields of medical practice.", Presented by President George W. Bush in the East Room of the White House on September 29, 2008.
  • 2007 - Albany Medical Center Prize in Medicine and Biomedical Research
  • 2003 - Distinguished Scientist Award, American Heart Association
  • 2001 - Jessie Stevenson Kovalenko Medal, US National Academy of Sciences For his elucidation of the structure, function, and mechanism of regulation of heptahelical receptors, nature's detectors of signals from many hormones, neurotransmitters, and drugs.
  • 2001 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 1994 - Member of the National Academy of Medicine (NAM)
  • 1988 - Canada Gairdner International Award
  • 1988 - Fellow of the American Academy of Arts and Sciences
  • 1988 - Member of the National Academy of Sciences
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Robert J. Lefkowitz is affiliated with Duke University in the United States. Their research encompasses a range of topics within biochemistry, genetics, and molecular biology, with significant contributions to medicine as well. The main subfields of study include molecular biology, cellular and molecular neuroscience, cardiology and cardiovascular medicine, spectroscopy, and psychiatry and mental health.

The scientist's work primarily focuses on receptor mechanisms and signaling, with additional emphasis on neuropeptides and animal physiology. Methodological approaches in their research cover mass spectrometry techniques, protein kinase regulation and GTPase signaling, and computational drug discovery methods. There is also involvement in research related to cancer, stress, anesthesia, and immune response, as well as monoclonal and polyclonal antibodies.

Frequent coauthors in collaboration with Robert J. Lefkowitz include Seungkirl Ahn, Alem W. Kahsai, Laura M. Wingler, Howard A. Rockman, and Dean P. Staus.

The scientist has published extensively, with recent notable papers including:

  • "Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc" (2020) in Nature
  • "Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR" (2020) in Science
  • "Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor" (2020) in Science
  • "Conformational Basis of G Protein-Coupled Receptor Signaling Versatility" (2020) in Trends in Cell Biology
  • "G Protein-Coupled Receptors: A Century of Research and Discovery" (2024) in Circulation Research

Key publication venues where Robert J. Lefkowitz has frequently contributed include UNC Libraries, Circulation Research, Proceedings of the National Academy of Sciences, Journal of Clinical Investigation, and bioRxiv hosted by Cold Spring Harbor Laboratory.

Among the recognitions received by the scientist are:

  • Fellow, National Academy of Inventors (2015)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2013)
  • Nobel Prize (2012) for studies of G-protein-coupled receptors
  • BBVA Foundation Frontiers of Knowledge Award (2009)
  • US President's National Medal of Science (2007), awarded for discovery of seven transmembrane receptors and elucidating their regulatory mechanisms
  • Albany Medical Center Prize in Medicine and Biomedical Research (2007)
  • Distinguished Scientist Award, American Heart Association (2003)
  • Jessie Stevenson Kovalenko Medal, US National Academy of Sciences (2001), recognizing elucidation of the structure, function, and regulation of heptahelical receptors
  • Robert J. and Claire Pasarow Foundation Medical Research Award (2001)
  • Member of the National Academy of Medicine (1994)
  • Fellow of the American Academy of Arts and Sciences (1988)
  • Canada Gairdner International Award (1988)
  • Member of the National Academy of Sciences (1988)
  • Member of the Association of American Physicians

Best Publications

  • Seven-transmembrane receptors.

    Kristen L. Pierce;Richard T. Premont;Robert J. Lefkowitz

  • Transduction of receptor signals by beta-arrestins.

    Robert J. Lefkowitz;Sudha K. Shenoy;Sudha K. Shenoy

  • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

    A De Lean;J M Stadel;R J Lefkowitz

  • Model systems for the study of seven-transmembrane-segment receptors.

    Henrik G. Dohlman;Jeremy Thorner;Marc G. Caron;Robert J. Lefkowitz

  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

    L. M. Luttrell;S. S. G. Ferguson;Y. Daaka;W. E. Miller

  • Turning off the signal: desensitization of beta-adrenergic receptor function.

    William P. Hausdorff;Marc G. Caron;Robert J. Lefkowitz

  • Cloning of the gene and cDNA for mammalian β -adrenergic receptor and homology with rhodopsin

    Richard A. F. Dixon;Brian K. Kobilka;David J. Strader;Jeffrey L. Benovic

  • β-Arrestins and Cell Signaling

    Scott M. DeWire;Seungkirl Ahn;Robert J. Lefkowitz;Sudha K. Shenoy

  • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

    Yehia Daaka;Louis M. Luttrell;Robert J. Lefkowitz

  • G protein-coupled receptor kinases.

    Julie A. Pitcher;Neil J. Freedman;Robert J. Lefkowitz

  • International Union of Pharmacology nomenclature of adrenoceptors.

    D B Bylund;D C Eikenberg;J P Hieble;S Z Langer

  • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

    P. Samama;S. Cotecchia;T. Costa;R.J. Lefkowitz

  • Beta-arrestin: a protein that regulates beta-adrenergic receptor function

    Martin J. Lohse;Jeffrey L. Benovic;Juan Codina;Marc G. Caron

  • The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

    Louis M. Luttrell;Robert J. Lefkowitz;Robert J. Lefkowitz

  • G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.

    Robert J. Lefkowitz

  • Seven-transmembrane-spanning receptors and heart function

    Howard A. Rockman;Walter J. Koch;Robert J. Lefkowitz

  • Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.

    Louis M. Luttrell;Francine L. Roudabush;Eric W. Choy;William E. Miller

  • An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior

    Jean-Martin Beaulieu;Tatyana D. Sotnikova;Sébastien Marion;Robert J. Lefkowitz

  • Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

    Laura M. Bohn;Robert J. Lefkowitz;Raul R. Gainetdinov;Karsten Peppel

  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.

    Laura M. Bohn;Raul R. Gainetdinov;Fang-Tsyr Lin;Robert J. Lefkowitz

Frequent Co-Authors

Marc G. Caron
Marc G. Caron Duke University
Walter J. Koch
Walter J. Koch Temple University
Louis M. Luttrell
Louis M. Luttrell Medical University of South Carolina
Seungkirl Ahn
Seungkirl Ahn Duke University
Howard A. Rockman
Howard A. Rockman Duke University
Richard T. Premont
Richard T. Premont University Hospitals of Cleveland
Sudha K. Shenoy
Sudha K. Shenoy Duke University
Brian K. Kobilka
Brian K. Kobilka Stanford University
John W. Regan
John W. Regan University of Arizona
Susanna Cotecchia
Susanna Cotecchia University of Lausanne

External Links

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Best Scientists Citing Robert J. Lefkowitz

Martin J. Lohse

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Publications: 201

Walter J. Koch

Walter J. Koch

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Publications: 197

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Vsevolod V. Gurevich

Vanderbilt University

Publications: 195

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Brian K. Kobilka

Stanford University

Publications: 193

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Marc G. Caron

Duke University

Publications: 183

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Jeffrey L. Benovic

Thomas Jefferson University

Publications: 182

Graeme Milligan

Graeme Milligan

University of Glasgow

Publications: 172

Michel Bouvier

Michel Bouvier

University of Montreal

Publications: 165

Stephen B. Liggett

Stephen B. Liggett

University of South Florida

Publications: 115

Joël Bockaert

Joël Bockaert

University of Montpellier

Publications: 114

Paul A. Insel

Paul A. Insel

University of California, San Diego

Publications: 110

Mark von Zastrow

Mark von Zastrow

University of California, San Francisco

Publications: 109

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Howard A. Rockman

Duke University

Publications: 107

Amitabha Chattopadhyay

Amitabha Chattopadhyay

Centre for Cellular and Molecular Biology

Publications: 106

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Bryan L. Roth

University of North Carolina at Chapel Hill

Publications: 104

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Raul R. Gainetdinov

Saint Petersburg State University

Publications: 102

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