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D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
15866
World Ranking
18201
National Ranking
7437

Overview

Seungkirl Ahn is affiliated with Duke University in the United States and focuses on research in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields, including Molecular Biology, Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Psychiatry and Mental Health, and Organic Chemistry.

The scientist's research primarily addresses topics related to receptor mechanisms and signaling, with over 30 publications in this area. Additional areas of study include neuropeptides and animal physiology, cancer, stress, anesthesia, and immune response, protein kinase regulation and GTPase signaling, renin-angiotensin system studies, cardiac electrophysiology and arrhythmias, and pharmacological receptor mechanisms and effects.

Notable recent papers authored or co-authored by Seungkirl Ahn include:

  • SnapShot: β-Arrestin Functions, 2020, Cell
  • Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin, 2023, Proceedings of the National Academy of Sciences
  • β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection, 2021, Molecular Pharmacology
  • Loss of biased signaling at a G protein-coupled receptor in overexpressed systems, 2023, PLoS ONE
  • Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor, 2021, Molecular Pharmacology

The scientist has frequently published in venues such as Molecular Pharmacology, Journal of Clinical Investigation, Circulation Research, UNC Libraries, and OPAL (Open@LaTrobe) at La Trobe University.

Ahn's collaborative network includes frequent co-authors like Robert J. Lefkowitz, Alem W. Kahsai, Biswaranjan Pani, Howard A. Rockman, and Samuel Liu.

Best Publications

  • β-Arrestins and Cell Signaling

    Scott M. DeWire;Seungkirl Ahn;Robert J. Lefkowitz;Sudha K. Shenoy

  • A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

    James W. Wisler;Scott M. DeWire;Erin J. Whalen;Jonathan D. Violin

  • Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

    Huijun Wei;Seungkirl Ahn;Sudha K. Shenoy;Sadashiva S. Karnik

  • Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor

    Seungkirl Ahn;Sudha K. Shenoy;Huijun Wei;Robert J. Lefkowitz;Robert J. Lefkowitz

  • β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7

    Sudarshan Rajagopal;Jihee Kim;Seungkirl Ahn;Stewart Craig

  • Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

    Kelly N. Nobles;Kunhong Xiao;Seungkirl Ahn;Arun K. Shukla;Arun K. Shukla

  • Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

    Yehia Daaka;Louis M. Luttrell;Seungkirl Ahn;Gregory J. Della Rocca

  • Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

    Eric Reiter;Seungkirl Ahn;Arun K. Shukla;Robert J. Lefkowitz

  • The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

    Stuart Maudsley;Kristen L. Pierce;A.Musa Zamah;William E. Miller

  • Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation

    Diane Gesty-Palmer;Minyong Chen;Eric Reiter;Seungkirl Ahn

  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

    Makoto R. Hara;Jeffrey J. Kovacs;Erin J. Whalen;Sudarshan Rajagopal

  • Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

    Wei Chen;Derk ten Berge;Jeff Brown;Seungkirl Ahn

  • Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling

    Jihee Kim;Seungkirl Ahn;Xiu Rong Ren;Erin J. Whalen

  • Quantifying ligand bias at seven-transmembrane receptors.

    Sudarshan Rajagopal;Seungkirl Ahn;David H. Rominger;William Gowen-MacDonald

  • Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor

    Xiu-Rong Ren;Eric Reiter;Seungkirl Ahn;Jihee Kim

  • Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

    Seungkirl Ahn;Stuart Maudsley;Louis M. Luttrell;Robert J. Lefkowitz

  • Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference

    Seungkirl Ahn;Christopher D. Nelson;Tiffany Runyan Garrison;William E. Miller

  • Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

    Dean P Staus;Ryan T Strachan;Aashish Manglik;Biswaranjan Pani

  • Introduction to Special Section on β-Arrestins

    Robert Lefkowitz

  • A unique mechanism of -blocker action: Carvedilol stimulates -arrestin signaling

    James W. Wisler;Scott M. DeWire;Erin J. Whalen;Jonathan D. Violin

Frequent Co-Authors

Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Louis M. Luttrell
Louis M. Luttrell Medical University of South Carolina
Sudha K. Shenoy
Sudha K. Shenoy Duke University
Brian K. Kobilka
Brian K. Kobilka Stanford University
Eric Reiter
Eric Reiter François Rabelais University
Yehia Daaka
Yehia Daaka University of Florida
Larry S. Barak
Larry S. Barak Duke University
William I. Weis
William I. Weis Stanford University
Els Pardon
Els Pardon Vrije Universiteit Brussel
Marc G. Caron
Marc G. Caron Duke University

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