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Biology and Biochemistry

D-Index
126
Citations
48612
World Ranking
496
National Ranking
315

Overview

Jeffrey L. Benovic is affiliated with Thomas Jefferson University in the United States. Their research primarily focuses on biochemical and molecular biology fields, with significant contributions to medicine as well.

Their work spans various subfields including molecular biology, cellular and molecular neuroscience, surgery, ophthalmology, and cell biology. Within these domains, they have concentrated on topics such as receptor mechanisms and signaling, neuropeptides and animal physiology, pancreatic function and diabetes, protein kinase regulation and GTPase signaling, diabetes treatment and management, pharmacological effects and assays, and ocular oncology and treatments.

Notable recent publications by Jeffrey L. Benovic include:

  • The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes (2024, Pharmacological Reviews)
  • Biased agonism at β-adrenergic receptors (2020, Cellular Signalling)
  • Targeting Oncogenic Gαq/11 in Uveal Melanoma (2021, Cancers)
  • Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting (2020, Molecular Cell)
  • Targeting G protein-coupled receptor kinases to G protein-coupled receptors (2020, Current Opinion in Endocrine and Metabolic Research)

Frequent co-authors collaborating with Benovic include Konstantin E. Komolov, Francesco De Pascali, Michael Ippolito, Brian K. Kobilka, and Daniela K. Laurinavichyute.

Jeffrey L. Benovic's research has been published multiple times in prominent venues such as:

  • Trends in Pharmacological Sciences (6 publications)
  • Journal of Biological Chemistry (4 publications)
  • Journal of Pharmacology and Experimental Therapeutics (4 publications)
  • The FASEB Journal (3 publications)
  • Cancers (2 publications)

Best Publications

  • Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor.

    Oscar B. Goodman;Jason G. Krupnick;Francesca Santini;Vsevolod V. Gurevich;Vsevolod V. Gurevich

  • Cloning of the gene and cDNA for mammalian β -adrenergic receptor and homology with rhodopsin

    Richard A. F. Dixon;Brian K. Kobilka;David J. Strader;Jeffrey L. Benovic

  • Beta-arrestin: a protein that regulates beta-adrenergic receptor function

    Martin J. Lohse;Jeffrey L. Benovic;Juan Codina;Marc G. Caron

  • THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

    Jason G. Krupnick;Jeffrey L. Benovic

  • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

    Julie A. Pitcher;James Inglese;Joyce B. Higgins;Jeffery L. Arriza

  • Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor

    Jeffrey L. Benovic;Ruth H. Strasser;Marc G. Caron;Robert J. Lefkowitz

  • Regulation of transmembrane signaling by receptor phosphorylation

    David R. Sibley;Jeffrey L. Benovic;Marc G. Caron;Robert J. Lefkowitz

  • Regulation of Receptor Trafficking by GRKs and Arrestins

    Catherine A.C. Moore;Shawn K. Milano;Jeffrey L. Benovic

  • Regulation of CXCR4 signaling.

    John M. Busillo;Jeffrey L. Benovic

  • Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)

    J L Benovic;H Kühn;I Weyand;J Codina

  • Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.

    Vsevolod V. Gurevich;Stephane B. Dion;James J. Onorato;Judith Ptasienski

  • Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal Sorting

    Adriano Marchese;Jeffrey L. Benovic

  • Regulation of adenylyl cyclase-coupled beta-adrenergic receptors.

    Jeffrey L. Benovic;Michel Bouvier;Marc G. Caron;Robert J. Lefkowitz

  • Beta-adrenergic receptor kinase: primary structure delineates a multigene family.

    JL Benovic;A DeBlasi;WC Stone;MG Caron

  • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

    M J Lohse;J L Benovic;M G Caron;R J Lefkowitz

  • Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

    Alexey N. Pronin;Andrew J. Morris;Andrei Surguchov;Jeffrey L. Benovic

  • The E3 Ubiquitin Ligase AIP4 Mediates Ubiquitination and Sorting of the G Protein-Coupled Receptor CXCR4

    Adriano Marchese;Camilla Raiborg;Francesca Santini;James H. Keen

  • Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

    J L Benovic;L J Pike;R A Cerione;C Staniszewski

  • Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.

    Christopher V. Carman;Jean Luc Parent;Peter W. Day;Alexey N. Pronin

  • Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin.

    V V Gurevich;J L Benovic

Frequent Co-Authors

Vsevolod V. Gurevich
Vsevolod V. Gurevich Vanderbilt University
Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Marc G. Caron
Marc G. Caron Duke University
Raymond B. Penn
Raymond B. Penn Thomas Jefferson University
M. Marlene Hosey
M. Marlene Hosey Northwestern University
Reynold A. Panettieri
Reynold A. Panettieri Rutgers, The State University of New Jersey
Eugenia V. Gurevich
Eugenia V. Gurevich Vanderbilt University
Michel Bouvier
Michel Bouvier University of Montreal
Christopher V. Carman
Christopher V. Carman Harvard University
Walter J. Koch
Walter J. Koch Temple University

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