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D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
10968
World Ranking
15046
National Ranking
6297

Overview

Raymond B. Penn is affiliated with Thomas Jefferson University in the United States. Their research has extensively covered areas within biochemistry, genetics, and molecular biology, with 38 publications. Medicine constitutes another major field of study, with 31 publications reflecting its significance in their work.

The scientist's subfield focus includes molecular biology, physiology, cellular and molecular neuroscience, pulmonary and respiratory medicine, and surgery. Specifically, molecular biology accounts for 31 publications, physiology for 14, cellular and molecular neuroscience for 9, pulmonary and respiratory medicine for 7, and surgery for 4.

Penn's research topics frequently encompass receptor mechanisms and signaling, as well as asthma and respiratory diseases. Other notable topics include neuropeptides and animal physiology, protein kinase regulation and GTPase signaling, PI3K/AKT/mTOR signaling in cancer, pancreatic function and diabetes, and cancer, stress, anesthesia, and immune response.

Frequent co-authors in Penn's research collaborations are Deepak A. Deshpande, Sushrut D. Shah, Ajay P. Nayak, Reynold A. Panettieri, and Dale D. Tang.

Key publication venues include the American Journal of Respiratory Cell and Molecular Biology with seven papers, the American Journal of Respiratory and Critical Care Medicine and the Proceedings of the National Academy of Sciences, each with three papers, The FASEB Journal with three papers, and UNC Libraries with two.

Notable recent publications by Penn include:

  • Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease, 2022, American Journal of Respiratory and Critical Care Medicine
  • The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR, 2020, Proceedings of the National Academy of Sciences
  • Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling, 2022, iScience
  • In silico identification of a β 2-adrenoceptor allosteric site that selectively augments canonical β 2 AR-Gs signaling and function, 2022, Proceedings of the National Academy of Sciences
  • Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling, 2021, American Journal of Respiratory Cell and Molecular Biology

Best Publications

  • Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor.

    Oscar B. Goodman;Jason G. Krupnick;Francesca Santini;Vsevolod V. Gurevich;Vsevolod V. Gurevich

  • Signaling and regulation of G protein-coupled receptors in airway smooth muscle

    Charlotte K Billington;Raymond B Penn

  • Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

    Alaina J. Ammit;Annette T. Hastie;Lisa C. Edsall;Rebecca K. Hoffman

  • Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists.

    Alaina J. Ammit;Aili L. Lazaar;Carla Irani;Geraldine M. O'Neill

  • Regulation of G protein-coupled receptor kinases.

    Raymond B Penn;Alexey N Pronin;Jeffrey L Benovic

  • Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

    Xi Ping Huang;Joel Karpiak;Wesley K. Kroeze;Hu Zhu

  • cAMP regulation of airway smooth muscle function.

    Charlotte K. Billington;Oluwaseun O. Ojo;Raymond B. Penn;Satoru Ito

  • Epinephrine Protects Cancer Cells from Apoptosis via Activation of cAMP-dependent Protein Kinase and BAD Phosphorylation

    Konduru S.R. Sastry;Yelena Karpova;Sergey Prokopovich;Adrienne J. Smith

  • A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.

    Guanghui Kong;R. Penn;J. L. Benovic

  • Visualization of Agonist-induced Sequestration and Down-regulation of a Green Fluorescent Protein-tagged β2-Adrenergic Receptor

    Lorena Kallal;Alison W. Gagnon;Raymond B. Penn;Jeffrey L. Benovic

  • Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

    Simon R. Foster;Alexander S. Hauser;Line Vedel;Ryan T. Strachan

  • Receptors and pathways mediating the effects of prostaglandin E2 on airway tone.

    Stephen L. Tilley;John M. Hartney;Christopher J. Erikson;Corey Jania

  • β 2 Agonists

    Charlotte K. Billington;Raymond B. Penn;Ian P. Hall

  • MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation.

    Michael J. Orsini;Vera P. Krymskaya;Andrew J. Eszterhas;Jeffrey L. Benovic

  • Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.

    Vera P. Krymskaya;Raymond B. Penn;Michael J. Orsini;Pamela H. Scott

  • Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate.

    Alaina J. Ammit;Rebecca K. Hoffman;Yassine Amrani;Aili L. Lazaar

  • Pharmacological Inhibition of Protein Kinases in Intact Cells: Antagonism of Beta Adrenergic Receptor Ligand Binding by H-89 Reveals Limitations of Usefulness

    Raymond B. Penn;Jean-Luc Parent;Alexey N. Pronin;Reynold A. Panettieri

  • Mechanisms of Proliferation Synergy by Receptor Tyrosine Kinase and G Protein–Coupled Receptor Activation in Human Airway Smooth Muscle

    Vera P. Krymskaya;Michael J. Orsini;Andrew J. Eszterhas;Kristin C. Brodbeck

  • Comparison of R-, S-, and RS-albuterol interaction with human beta 1- and beta 2-adrenergic receptors.

    Raymond B. Penn;Thomas Frielle;John R. McCullough;Gunnar Aberg

  • Epinephrine Protects Cancer Cells from Apoptosis via Activation of cAMP-dependent Protein Kinase

    Konduru S. R. Sastry;Yelena Karpova;Sergey Prokopovich;Adrienne J. Smith

Frequent Co-Authors

Reynold A. Panettieri
Reynold A. Panettieri Rutgers, The State University of New Jersey
Jeffrey L. Benovic
Jeffrey L. Benovic Thomas Jefferson University
Stephen P. Peters
Stephen P. Peters Wake Forest University
Ian P. Hall
Ian P. Hall University of Nottingham
Yassine Amrani
Yassine Amrani University of Leicester
Vsevolod V. Gurevich
Vsevolod V. Gurevich Vanderbilt University
Beverly H. Koller
Beverly H. Koller University of North Carolina at Chapel Hill
Eugene R. Bleecker
Eugene R. Bleecker University of Arizona
Ulrich Rodeck
Ulrich Rodeck Thomas Jefferson University
Bryan L. Roth
Bryan L. Roth University of North Carolina at Chapel Hill

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