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D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
7773
World Ranking
17737
National Ranking
1398

Overview

Yassine Amrani is affiliated with the University of Leicester in the United Kingdom. Their research primarily focuses on medical sciences, with a significant emphasis on physiology and pulmonary and respiratory medicine. The body of work also intersects with biomedical engineering, immunology, and molecular biology, reflecting a multidisciplinary approach.

The main topics covered in their research include:

  • Asthma and respiratory diseases
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Biosensors and Analytical Detection
  • Microfluidic and Bio-sensing Technologies
  • Allergic Rhinitis and Sensitization
  • Neuropeptides and Animal Physiology
  • Mast cells and histamine

Yassine Amrani has published studies in several scientific journals. Frequent publication venues include:

  • Free Radical Biology and Medicine
  • Immunobiology
  • British Journal of Pharmacology
  • Microchimica Acta
  • International Journal of Molecular Sciences

Recent papers by Amrani and collaborators demonstrate their ongoing engagement with respiratory and inflammatory diseases. Notable publications are:

  • Stressed out - The role of oxidative stress in airway smooth muscle dysfunction in asthma and COPD, 2022, Free Radical Biology and Medicine
  • GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function, 2020, Immunobiology
  • Important lessons learned from studies on the pharmacology of glucocorticoids in human airway smooth muscle cells: Too much of a good thing may be a problem, 2020, Pharmacology & Therapeutics
  • TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels, 2021, British Journal of Pharmacology
  • Human Lung Mast Cells Impair Corticosteroid Responsiveness in Human Airway Smooth Muscle Cells, 2021, Frontiers in Allergy

The scientist collaborates with several frequent co-authors, including Peter Bradding, Michael Biddle, Omar Tliba, Sana Douaoui, and Mustapha Oumouna. These collaborations underline a recurring network of research partnerships in respiratory and immunological fields.

Best Publications

  • Targeting TNF-α: A novel therapeutic approach for asthma

    Christopher Brightling;Mike Berry;Yassine Amrani

  • Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

    Alaina J. Ammit;Annette T. Hastie;Lisa C. Edsall;Rebecca K. Hoffman

  • Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists.

    Alaina J. Ammit;Aili L. Lazaar;Carla Irani;Geraldine M. O'Neill

  • Synthetic responses in airway smooth muscle

    Peter H Howarth;Alan J Knox;Yassine Amrani;Omar Tliba

  • IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle.

    Omar Tliba;Deepak Deshpande;Hang Chen;Christopher Van Besien

  • Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway.

    Deepak A. Deshpande;Soner Dogan;Timothy F. Walseth;Steven M. Miller

  • Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.

    Vera P. Krymskaya;Raymond B. Penn;Michael J. Orsini;Pamela H. Scott

  • Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate.

    Alaina J. Ammit;Rebecca K. Hoffman;Yassine Amrani;Aili L. Lazaar

  • Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma

    Andrew J. Halayko;Yassine Amrani

  • IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

    D. Kaur;E. Gomez;C. Doe;R. Berair

  • Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?

    Yassine Amrani;Hang Chen;Reynold A Panettieri

  • Activation of the TNF alpha-p55 receptor induces myocyte proliferation and modulates agonist-evoked calcium transients in cultured human tracheal smooth muscle cells

    Yassine Amrani;Reynold A. Panettieri;Nelly Frossard;Christian Bronner

  • Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells.

    Hans M Rosenfeldt;Yassine Amrani;Kenneth R Watterson;Karnam S Murthy

  • Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases

    Yassine Amrani;Alaina J. Ammit;Reynold A. Panettieri

  • Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent

    Altaf S. Kazi;Shidan Lotfi;Elena A. Goncharova;Omar Tliba

  • Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma.

    Yassine Amrani;Reynold A. Panettieri

  • Up-Regulation of ICAM-1 by Cytokines in Human Tracheal Smooth Muscle Cells Involves an NF-κB-Dependent Signaling Pathway That Is Only Partially Sensitive to Dexamethasone

    Yassine Amrani;Aili L. Lazaar;Reynold A. Panettieri

  • Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1.

    Omar Tliba;Gautam Damera;Audreesh Banerjee;Su Gu

  • Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release.

    I Gurubhagavatula;Y Amrani;D Pratico;F L Ruberg

  • CD38 Expression Is Insensitive to Steroid Action in Cells Treated with Tumor Necrosis Factor-α and Interferon-γ by a Mechanism Involving the Up-Regulation of the Glucocorticoid Receptor β Isoform

    Omar Tliba;John A. Cidlowski;Yassine Amrani

Frequent Co-Authors

Reynold A. Panettieri
Reynold A. Panettieri Rutgers, The State University of New Jersey
Christopher E. Brightling
Christopher E. Brightling University of Leicester
Peter Bradding
Peter Bradding University of Leicester
Y. S. Prakash
Y. S. Prakash Mayo Clinic
Carol Feghali-Bostwick
Carol Feghali-Bostwick Medical University of South Carolina
Raymond B. Penn
Raymond B. Penn Thomas Jefferson University
Timothy F. Walseth
Timothy F. Walseth University of Minnesota
Angela Franciska Haczku
Angela Franciska Haczku University of California, Davis
Ellen Puré
Ellen Puré University of Pennsylvania
Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University

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