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Biology and Biochemistry

D-Index
83
Citations
26335
World Ranking
3477
National Ranking
1747

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ellen Puré is affiliated with the University of Pennsylvania in the United States. Their research primarily bridges Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on oncology and immunology.

Their published work includes investigations into cancer-associated fibroblasts and their role in tumor biology, immunity, and immunotherapy. Notable recent papers include:

  • A framework for advancing our understanding of cancer-associated fibroblasts (2020, Nature reviews. Cancer)
  • Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy (2020, eLife)
  • Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors (2023, Nature Communications)
  • A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression (2022, Nature Cell Biology)
  • Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy (2020, Current Opinion in Immunology)

The major topics covered in their research include:

  • Peptidase Inhibition and Analysis
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Cancer Immunotherapy and Biomarkers
  • Cancer Research and Treatments
  • Cancer Cells and Metastasis
  • Immunotherapy and Immune Responses

Frequent coauthors collaborating with Ellen Puré include Zebin Xiao, Leslie Todd, Estela Noguera-Ortega, Maria Liousia, and Steven Μ. Albelda.

Their research outputs are regularly published in venues that include:

  • Cancer Research
  • Cancer Immunology Research
  • Nature reviews. Cancer
  • Nature Cell Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Puré's work is strongly situated within the subfields of oncology, immunology, molecular biology, biotechnology, and cancer research more broadly.

In recognition of their contributions, Ellen Puré was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2019.

Best Publications

  • A framework for advancing our understanding of cancer-associated fibroblasts

    Erik Sahai;Igor Astsaturov;Edna Cukierman;David G. DeNardo

  • The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

    Huang Q;Gumireddy K;Schrier M;le Sage C

  • Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors

    Vinit Kumar;Laxminarasimha Donthireddy;Douglas Marvel;Thomas Condamine

  • Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity.

    Liang-Chuan S. Wang;Albert Lo;John Scholler;Jing Sun

  • T cell-derived b cell differentiation factor(s) effect on the isotype switch of murine b cells

    Peter C. Isakson;Peter C. Isakson;Ellen Pure;Ellen Pure;Ellen S. Vitetta;Ellen S. Vitetta;Peter H. Krammer

  • Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells

    Albert Lo;Liang-Chuan S. Wang;John Scholler;James Monslow

  • Targeting cardiac fibrosis with engineered T cells.

    Haig Aghajanian;Toru Kimura;Joel G. Rurik;Aidan S. Hancock

  • Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of Apolipoprotein A-I in Mice

    Rajendra K. Tangirala;Kazuhisa Tsukamoto;Sam H. Chun;David Usher

  • Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

    Angélica M. Santos;Jason Jung;Nazneen Aziz;Joseph L. Kissil

  • Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors

    Edmund K. Moon;Liang-Chuan Wang;Douglas V. Dolfi;Caleph B. Wilson

  • The liberation of CD44

    Joanna Cichy;Ellen Puré;Ellen Puré

  • The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation

    Carolyn A. Cuff;Devashish Kothapalli;Ijeoma Azonobi;Sam Chun

  • Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages.

    J Hodge-Dufour;P W Noble;M R Horton;C Bao

  • Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics

    Ellen Puré;Rachel Blomberg

  • The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.

    Alan Daugherty;Ellen Puré;Dustie Delfel-Butteiger;Sam Chen

  • T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis.

    Aili L. Lazaar;Steven M. Albelda;Joseph M. Pilewski;Brian Brennan

  • Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice

    Patricia A. Detmers;Melba Hernandez;John Mudgett;Heide Hassing

  • Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis

    T.S. Karin Eisinger-Mathason;Minsi Zhang;Qiong Qiu;Nicolas Skuli

  • Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation

    Marian L. Birkeland;Pauline Johnson;Ian S. Trowbridge;Ellen Pure

  • Vascular COX-2 modulates blood pressure and thrombosis in mice.

    Ying Yu;Emanuela Ricciotti;Rosario Scalia;Soon Yew Tang

Frequent Co-Authors

Daniel J. Rader
Daniel J. Rader University of Pennsylvania
Steven M. Albelda
Steven M. Albelda University of Pennsylvania
Richard K. Assoian
Richard K. Assoian University of Pennsylvania
Garret A. FitzGerald
Garret A. FitzGerald University of Pennsylvania
Carl H. June
Carl H. June University of Pennsylvania
Ellen S. Vitetta
Ellen S. Vitetta The University of Texas Southwestern Medical Center
Reynold A. Panettieri
Reynold A. Panettieri Rutgers, The State University of New Jersey
Peter H. Krammer
Peter H. Krammer German Cancer Research Center
Wolfgang Weninger
Wolfgang Weninger Medical University of Vienna
Ian A. Blair
Ian A. Blair University of Pennsylvania

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