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Medicine

D-Index
101
Citations
33323
World Ranking
8051
National Ranking
4180

Overview

Alan Daugherty is affiliated with the University of Kentucky in the United States. Their research output includes extensive work in medicine, with a primary focus on pulmonary and respiratory medicine, surgery, cardiology and cardiovascular medicine, genetics, and endocrinology, diabetes, and metabolism. Their research topics concentrate on aortic aneurysm repair treatments, aortic disease and treatment approaches, connective tissue disorders research, hormonal regulation and hypertension, infectious aortic and vascular conditions, renin-angiotensin system studies, as well as atherosclerosis and cardiovascular diseases.

Daugherty has contributed to numerous publications, particularly in the following venues:

  • Arteriosclerosis Thrombosis and Vascular Biology (60 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (23 publications)
  • Circulation (12 publications)
  • JVS Vascular Science (6 publications)
  • Cardiovascular Research (5 publications)

Some of their recent papers include:

  • "Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue," 2020, Circulation
  • "Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection," 2021, European Heart Journal
  • "Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms," 2021, The Journal of Experimental Medicine
  • "Aortic Aneurysms and Dissections Series," 2020, Arteriosclerosis Thrombosis and Vascular Biology
  • "Twenty Years of Studying AngII (Angiotensin II)-Induced Abdominal Aortic Pathologies in Mice: Continuing Questions and Challenges to Provide Insight Into the Human Disease," 2022, Arteriosclerosis Thrombosis and Vascular Biology

The scientist collaborates frequently with several researchers, including:

  • Hong Lü
  • Hisashi Sawada
  • Deborah A. Howatt
  • Michael Franklin
  • Jessica J. Moorleghen

Their work addresses complex cardiovascular and vascular conditions, including various aspects of aortic diseases and cellular mechanisms underlying these disorders. The research encompasses genetic and molecular pathways, metabolic biomarkers, and inflammatory processes related to aneurysm formation and progression.

Best Publications

  • Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

    Alan Daugherty;Julie L. Dunn;Debra L. Rateri;Jay W. Heinecke

  • Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice

    Alan Daugherty;Michael W. Manning;Lisa A. Cassis

  • Use of Nonsteroidal Antiinflammatory Drugs. An Update for Clinicians. A Scientific Statement From the American Heart Association

    Elliott M. Antman;Joel S. Bennett;Alan Daugherty;Curt Furberg

  • Translating molecular discoveries into new therapies for atherosclerosis.

    Daniel J. Rader;Alan Daugherty

  • Abdominal aortic aneurysm : Pathogenesis and implications for management

    Jonathan Golledge;Juanita Muller;Alan Daugherty;Paul Norman

  • Mouse Models of Abdominal Aortic Aneurysms

    Alan Daugherty;Lisa A. Cassis

  • Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E−/− Mice Through Release of Interferon-γ

    Stewart C. Whitman;Punnaivanam Ravisankar;Alan Daugherty

  • Exogenous interferon-γ enhances atherosclerosis in apolipoprotein E-/- mice

    Stewart C. Whitman;Punnaivanam Ravisankar;Haley Elam;Alan Daugherty

  • Aortic Dissection Precedes Formation of Aneurysms and Atherosclerosis in Angiotensin II-Infused, Apolipoprotein E-Deficient Mice

    Kiran Saraff;Fjoralba Babamusta;Lisa A. Cassis;Alan Daugherty

  • Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

    Alan Daugherty;Alan R. Tall;Mat J.A.P. Daemen;Erling Falk

  • Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension

    Carine M Boustany;Kalyani Bharadwaj;Alan Daugherty;David R Brown

  • Differential Effects of Doxycycline, a Broad-Spectrum Matrix Metalloproteinase Inhibitor, on Angiotensin II-Induced Atherosclerosis and Abdominal Aortic Aneurysms

    Michael W. Manning;Lisa A. Cassis;Alan Daugherty

  • Interleukin-4 Deficiency Decreases Atherosclerotic Lesion Formation in a Site-Specific Manner in Female LDL Receptor−/− Mice

    Victoria L. King;Stephen J. Szilvassy;Alan Daugherty

  • Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.

    Alan Daugherty;Michael W Manning;Lisa A Cassis

  • Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein

    Anne M. Fagan;Guojun Bu;Yuling Sun;Alan Daugherty

  • Mouse Models of Atherosclerosis

    Alan Daugherty

  • Inflammasome activation triggers blood clotting and host death through pyroptosis

    Congqing Wu;Wei Lu;Yan Zhang;Guoying Zhang

  • Hypercholesterolemia Stimulates Angiotensin Peptide Synthesis and Contributes to Atherosclerosis Through the AT1A Receptor

    Alan Daugherty;Debra L. Rateri;Hong Lu;Tadashi Inagami

  • Obesity Promotes Inflammation in Periaortic Adipose Tissue and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation

    Sean E. Thatcher;Richard Charnigo;Alan Daugherty

  • The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.

    Alan Daugherty;Ellen Puré;Dustie Delfel-Butteiger;Sam Chen

Frequent Co-Authors

Lisa A. Cassis
Lisa A. Cassis University of Kentucky
Scott A. LeMaire
Scott A. LeMaire Baylor College of Medicine
Gustav Schonfeld
Gustav Schonfeld Washington University in St. Louis
Nancy R. Webb
Nancy R. Webb University of Kentucky
Nigel Mackman
Nigel Mackman University of North Carolina at Chapel Hill
Daniel J. Rader
Daniel J. Rader University of Pennsylvania
Jonathan Golledge
Jonathan Golledge James Cook University
Masanori Aikawa
Masanori Aikawa Brigham and Women's Hospital
Bernhard Hennig
Bernhard Hennig University of Kentucky
Dudley K. Strickland
Dudley K. Strickland American Red Cross

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