2026 Nigel Mackman: Medicine Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Medicine	136	1983	1848	1126	1036	663	67788

Overview

Nigel Mackman is affiliated with the University of North Carolina at Chapel Hill in the United States. Their primary field of study is Medicine with a strong focus on Hematology, Internal Medicine, Immunology, Molecular Biology, and Genetics as significant subfields of research.

Their research encompasses multiple topics related to blood and coagulation, including:

Blood Coagulation and Thrombosis Mechanisms
Venous Thromboembolism Diagnosis and Management
Extracellular vesicles in disease
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Platelet Disorders and Treatments
Hemophilia Treatment and Research
COVID-19 Clinical Research Studies

Nigel Mackman has contributed to several recent papers, including:

Therapeutic strategies for thrombosis: new targets and approaches, 2020, Nature Reviews Drug Discovery
Cancer-associated venous thromboembolism, 2022, Nature Reviews Disease Primers (lead author: Alok A. Khorana)
Understanding COVID-19-associated coagulopathy, 2022, Nature Reviews Immunology (lead author: Edward M. Conway)
Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report, 2020, Arteriosclerosis Thrombosis and Vascular Biology (lead author: Axel Rosell)
Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19, 2020, Arteriosclerosis Thrombosis and Vascular Biology (lead author: Henry Ng)

Frequent collaborators in their research include:

Yohei Hisada
Steven P. Grover
Silvio Antoniak
Alisa S. Wolberg
Charlotte Thålin

Mackman's work is regularly published in several venues, with notable numbers of publications in:

UNC Libraries
Research and Practice in Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
Arteriosclerosis Thrombosis and Vascular Biology
Blood

Best Publications

LPS induction of gene expression in human monocytes

Mausumee Guha;Nigel Mackman

3360
Citations
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

Thorsten Cramer;Yuji Yamanishi;Björn E Clausen;Irmgard Förster

2468
Citations
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

Marie-Luise von Brühl;Konstantin Stark;Alexander Steinhart;Sue Chandraratne

1971
Citations
Triggers, targets and treatments for thrombosis

Nigel Mackman

1401
Citations
The Phosphatidylinositol 3-Kinase-Akt Pathway Limits Lipopolysaccharide Activation of Signaling Pathways and Expression of Inflammatory Mediators in Human Monocytic Cells

Mausumee Guha;Nigel Mackman

1177
Citations
Microparticles in Hemostasis and Thrombosis

A. Phillip Owens;Nigel Mackman

963
Citations
Role of the Extrinsic Pathway of Blood Coagulation in Hemostasis and Thrombosis

Nigel Mackman;Rachel E. Tilley;Nigel S. Key

925
Citations
Methodological Guidelines to Study Extracellular Vesicles.

Frank A.W. Coumans;Alain R. Brisson;Edit I. Buzas;Françoise Dignat-George

917
Citations
Role of tissue factor in embryonic blood vessel development

Peter Carmeliet;N Mackman;Lieve Moons;T Luther

888
Citations
Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development

Nigel Mackman

864
Citations
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.

Laurence Arbibe;Jean Paul Mira;Jean Paul Mira;Nicole Teusch;Lois Kline

825
Citations
The structural biology of expression and function of tissue factor.

Thomas S Edgington;Nigel Mackman;Korbinian Brand;Wolfram Ruf

810
Citations
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.

Joanne L. Yu;Linda May;Vladimir Lhotak;Siranoush Shahrzad

769
Citations
Regulation of the tissue factor gene.

Nigel Mackman

699
Citations
Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells REGULATION BY Egr-1, c-Jun, AND NF-κB TRANSCRIPTION FACTORS

Jin Yao;Nigel Mackman;Thomas S. Edgington;Sao Tah Fan

694
Citations
Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress

Shi Fang Yan;Tomoyuki Fujita;Jiesheng Lu;Kenji Okada

652
Citations
Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites.

Nigel Mackman;Korbinian Brand;Thomas S. Edgington

535
Citations
Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis.

Steven P. Grover;Nigel Mackman

510
Citations
Role of Tissue Factor in Cancer

Raj S. Kasthuri;Mark B. Taubman;Nigel Mackman

494
Citations
New insights into the mechanisms of venous thrombosis.

Nigel Mackman

455
Citations

Frequent Co-Authors

Nigel S. Key University of North Carolina at Chapel Hill

Thomas S. Edgington Scripps Research Institute

Alan Daugherty University of Kentucky

Daniel Kirchhofer Genentech

Dougald M. Monroe University of North Carolina at Chapel Hill

Wolfram Ruf Johannes Gutenberg University of Mainz

Bruce Furie Beth Israel Deaconess Medical Center

Frank C. Church University of North Carolina at Chapel Hill

David M. Stern University of Tennessee Health Science Center

Melinda A. Beck University of North Carolina at Chapel Hill

External Links

Personal website of Nigel Mackman

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