World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
11261
World Ranking
17051
National Ranking
7028

Overview

Frank C. Church is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans multiple fields with a strong focus on medicine and biochemistry, genetics, and molecular biology. Within these disciplines, their work specializes in neurology, molecular biology, hematology, education, and cancer research.

The scientist has contributed significantly to understanding the mechanisms and treatments of Parkinson's disease, as well as exploring protease and inhibitor mechanisms. Their research topics also include blood coagulation and thrombosis mechanisms, the long-term effects of COVID-19, innovative teaching methods, problem and project-based learning, and genetic neurodegenerative diseases.

Frequent publication venues for Frank C. Church include:

  • UNC Libraries
  • Brain Sciences
  • Education Sciences
  • Biomolecules
  • Medical Hypotheses

Their recent papers include the following:

  • Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease, 2021, Biomolecules
  • Potential Role of Vitamin D in the Elderly to Resist COVID-19 and to Slow Progression of Parkinson's Disease, 2020, Brain Sciences
  • The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins: Evolution, Mechanism of Inhibition, Novel Functions, and a Revised Nomenclature, 2021, UNC Libraries
  • Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson's disease, 2020, Medical Hypotheses
  • Active Learning: Subtypes, Intra-Exam Comparison, and Student Survey in an Undergraduate Biology Course, 2020, Education Sciences

Among frequent co-authors are Lea M. Beaulieu, Rebecca R. Bliss, Herbert C. Whinna, Casey A. Hribar, and P H Cobbold, reflecting ongoing collaborative research within the domains of biology and medicine.

The scientist's primary research topics include:

  • Blood Coagulation and Thrombosis Mechanisms
  • Long-Term Effects of COVID-19
  • Parkinson's Disease Mechanisms and Treatments
  • Protease and Inhibitor Mechanisms
  • Innovative Teaching Methods
  • Problem and Project Based Learning
  • Genetic Neurodegenerative Diseases

Frank C. Church's work integrates clinical and molecular approaches, contributing to a deeper understanding of disease mechanisms and potential interventions, as well as advancing educational methodologies within the life sciences.

Best Publications

  • Spectrophotometric Assay Using o-Phthaldialdehyde for Determination of Proteolysis in Milk and Isolated Milk Proteins

    Frank C. Church;Harold E. Swaisgood;David H. Porter;George L. Catignani

  • The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

    Gary A. Silverman;Phillip I. Bird;Robin W. Carrell;Frank C. Church

  • Serpins in thrombosis, hemostasis and fibrinolysis

    J. C. Rau;L. M. Beaulieu;J. A. Huntington;Frank C. Church

  • Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin.

    F C Church;J B Meade;R E Treanor;H C Whinna

  • Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

    Trevor P. Baglin;Robin W. Carrell;Frank C. Church;Charles T. Esmon

  • Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin Complex

    Alireza R. Rezaie;Scott T. Cooper;Frank C. Church;Charles T. Esmon;Charles T. Esmon;Charles T. Esmon

  • An o-phthalaldehyde spectrophotometric assay for proteinases☆

    Frank C. Church;David H. Porter;George L. Catignani;Harold E. Swaisgood

  • Cellular Internalization and Degradation of Antithrombin III-Thrombin, Heparin Cofactor II-Thrombin, and α1-Antitrypsin-Trypsin Complexes Is Mediated by the Low Density Lipoprotein Receptor-related Protein

    Maria Z. Kounnas;Frank C. Church;W. Scott Argraves;Dudley K. Strickland

  • Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.

    Jian Guo Wang;Julia E. Geddings;Maria M. Aleman;Jessica C. Cardenas

  • Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice

    Kellie R. Machlus;Jessica C. Cardenas;Frank C. Church;Alisa S. Wolberg

  • Reactive site peptide structural similarity between heparin cofactor II and antithrombin III.

    M J Griffith;C M Noyes;F C Church

  • Control of the coagulation system by serpins: getting by with a little help from glycosaminoglycans

    Robert Neil Pike;Ashley Maurice Buckle;Bernard Le Bonniec;Frank C Church

  • Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin cofactor II and antithrombin

    Carrie A Holland;Alexis T Henry;Herbert C Whinna;Frank C Church

  • Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease.

    Frank C Church

  • Interaction of heparin cofactor II with biglycan and decorin.

    Herbert C. Whinna;Haing U. Choi;Lawrence C. Rosenberg;Frank C. Church

  • Heparin binding to protein C inhibitor.

    Charlotte W. Pratt;Frank C. Church

  • Characterization of the Glycosaminoglycan-Binding Region of Lactoferrin

    Hai-Feng Wu;D. M. Monroe;F. C. Church

  • Antithrombin: structure and function.

    Charlotte W. Pratt;Frank C. Church

  • Plasminogen activator inhibitor-1 and -3 increase cell adhesion and motility of MDA-MB-435 breast cancer cells.

    Diane Palmieri;Jung Weon Lee;Rudy L. Juliano;Frank C. Church

  • A comparison of three heparin-binding serine proteinase inhibitors.

    Charlotte W. Pratt;Herbert C. Whinna;Frank C. Church

Frequent Co-Authors

Nigel Mackman
Nigel Mackman University of North Carolina at Chapel Hill
Dougald M. Monroe
Dougald M. Monroe University of North Carolina at Chapel Hill
Charles T. Esmon
Charles T. Esmon Oklahoma Medical Research Foundation
Alireza R. Rezaie
Alireza R. Rezaie Oklahoma Medical Research Foundation
Douglas M. Tollefsen
Douglas M. Tollefsen Washington University in St. Louis
Nigel S. Key
Nigel S. Key University of North Carolina at Chapel Hill
Lawrence L. K. Leung
Lawrence L. K. Leung Stanford University
Norman E. Sharpless
Norman E. Sharpless National Institutes of Health
James A. Huntington
James A. Huntington University of Cambridge
Dudley K. Strickland
Dudley K. Strickland American Red Cross

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Frank C. Church

Trending Scientists