What is he best known for?
The fields of study he is best known for:
- Enzyme
- Biochemistry
- Amino acid
Frank C. Church mostly deals with Biochemistry, Thrombin, Antithrombin, Heparin cofactor II and Heparin.
His study in Biochemistry is interdisciplinary in nature, drawing from both Molecular biology, Chromatography and Protein C inhibitor.
Frank C. Church studies Thrombin, focusing on Thrombomodulin in particular.
The concepts of his Antithrombin study are interwoven with issues in Serine Proteinase Inhibitors and Immunology.
His Heparin cofactor II research incorporates themes from Dermatan sulfate, Protease and Cell biology.
His work is dedicated to discovering how Heparin, Cofactor are connected with Peptide and other disciplines.
His most cited work include:
- The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature (1046 citations)
- Serpins in thrombosis, hemostasis and fibrinolysis (243 citations)
- Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism (169 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Biochemistry, Thrombin, Heparin cofactor II, Molecular biology and Serpin.
His research investigates the connection between Biochemistry and topics such as Protein C inhibitor that intersect with problems in Protein C.
His research in Thrombin intersects with topics in Glycosaminoglycan, Stereochemistry, Coagulation and Active site.
His Heparin cofactor II research focuses on Dermatan sulfate and how it connects with Proteoglycan.
His studies in Molecular biology integrate themes in fields like Plasminogen activator, Plasminogen activator inhibitor-1, Proteolysis, Chymotrypsin and Protease-activated receptor.
His Heparin research includes themes of Cofactor and Pharmacology.
He most often published in these fields:
- Biochemistry (59.35%)
- Thrombin (52.26%)
- Heparin cofactor II (42.58%)
What were the highlights of his more recent work (between 2008-2021)?
- Plasminogen activator (16.13%)
- Cancer research (9.03%)
- Thrombin (52.26%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Plasminogen activator, Cancer research, Thrombin, Plasminogen activator inhibitor-1 and Internal medicine.
His work deals with themes such as Cell, Cell type, Molecular biology, Receptor and Motility, which intersect with Plasminogen activator.
His Cancer research research integrates issues from Fibrinolysis, Plasmin, Urokinase and Tissue factor.
Frank C. Church is interested in Heparin cofactor II, which is a branch of Thrombin.
His work in Internal medicine tackles topics such as Endocrinology which are related to areas like Peroxisome proliferator-activated receptor, Breast cancer, Cancer and Protease-Activated Receptor 1.
As a member of one scientific family, Frank C. Church mostly works in the field of Protease, focusing on Proteases and, on occasion, Heparan sulfate.
Between 2008 and 2021, his most popular works were:
- Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. (127 citations)
- Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice (115 citations)
- Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor- and Plasminogen Activator Inhibitor-1 (57 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Amino acid
- Biochemistry
Internal medicine, Plasminogen activator inhibitor-1, Plasminogen activator, Endocrinology and Fibrinolysis are his primary areas of study.
The concepts of his Plasminogen activator inhibitor-1 study are interwoven with issues in Cell signaling, Tissue factor, Molecular biology and Protease-activated receptor, Thrombin.
His work in Plasminogen activator is not limited to one particular discipline; it also encompasses Angiogenesis.
His research integrates issues of Cancer, Breast cancer and Protease-Activated Receptor 1 in his study of Endocrinology.
The study incorporates disciplines such as Thrombosis, Cancer research and Cardiology in addition to Fibrinolysis.
His Cancer research research is multidisciplinary, incorporating elements of Urokinase receptor, Urokinase, Immunology, Tissue plasminogen activator and Vitronectin.
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