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Microbiology

D-Index
47
Citations
6697
World Ranking
4830
National Ranking
1860

Overview

Nigel Bourne is affiliated with The University of Texas Medical Branch at Galveston in the United States. Their research primarily focuses on infectious diseases within the broader field of medicine, with a particular emphasis on viral infections and vectors, mosquito-borne diseases and control, and public health aspects related to these topics.

The scientist's publications cover a range of topics in virology, epidemiology, immunology, and public health, reflecting an interdisciplinary approach to combating viral infections and outbreaks. Their subfields of study include infectious diseases, epidemiology, immunology, and occupational health, among others.

Recent papers authored or co-authored by Nigel Bourne include:

  • Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates (2023, Nature)
  • Baseline mapping of Oropouche virology, epidemiology, therapeutics, and vaccine research and development (2022, npj Vaccines)
  • Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality (2020, Science Translational Medicine)
  • Japanese encephalitis virus live attenuated vaccine strains display altered immunogenicity, virulence and genetic diversity (2021, npj Vaccines)
  • Vaccine value profile for Chikungunya (2023, Vaccine)

Their frequent co-authors include:

  • Alan D.T. Barrett
  • Gregg N. Milligan
  • David W. C. Beasley
  • Annelies Wilder-Smith
  • Clairissa A. Hansen

Nigel Bourne has contributed to multiple publication venues, notably:

  • npj Vaccines
  • The Lancet Infectious Diseases
  • Viruses
  • Nature
  • Science Translational Medicine

The main topics of their work encompass viral infections and vectors, mosquito-borne diseases and control, viral infections and outbreaks research, malaria research and control, virology and viral diseases, plant virus studies, and herpesvirus infections and treatments.

This range highlights a consistent focus on understanding viral pathogens and the interplay between vectors and human health, contributing to vaccine research and epidemiological mapping.

Best Publications

  • An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

    Chao Shan;Xuping Xie;Antonio E. Muruato;Shannan L. Rossi

  • T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2

    Gregg N. Milligan;David I. Bernstein;Nigel Bourne

  • Multiple effects of silymarin on the hepatitis C virus lifecycle.

    Jessica Wagoner;Amina Negash;Olivia J Kane;Laura E Martinez

  • Dendrimers, a New Class of Candidate Topical Microbicides with Activity against Herpes Simplex Virus Infection

    Nigel Bourne;L. R. Stanberry;E. R. Kern;G. Holan

  • Plant products as topical microbicide candidates: Assessment of in vitro and in vivo activity against herpes simplex virus type 2

    Krystyn Z. Bourne;Nigel Bourne;Shirley F. Reising;Lawrence R. Stanberry

  • DNA Immunization against Experimental Genital Herpes Simplex Virus Infection

    Nigel Bourne;Lawrence R. Stanberry;David I. Bernstein;Denise Lew

  • PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

    Angela M. Lam;Eisuke Murakami;Christine Espiritu;Holly M. Micolochick Steuer

  • Herpes Simplex Virus (HSV) Type 2 Glycoprotein D Subunit Vaccines and Protection against Genital HSV-1 or HSV-2 Disease in Guinea Pigs

    Nigel Bourne;Fernando J Bravo;Myriam Francotte;David I Bernstein

  • Evaluations of Unformulated and Formulated Dendrimer-Based Microbicide Candidates in Mouse and Guinea Pig Models of Genital Herpes

    D. I. Bernstein;L. R. Stanberry;L. R. Stanberry;S. Sacks;N. K. Ayisi

  • Protection against Congenital Cytomegalovirus Infection and Disease in Guinea Pigs, Conferred by a Purified Recombinant Glycoprotein B Vaccine

    Mark R. Schleiss;Nigel Bourne;Greg Stroup;Fernando J. Bravo

  • Poly(Sodium 4-Styrene Sulfonate): An Effective Candidate Topical Antimicrobial for the Prevention of Sexually Transmitted Diseases

    Betsy C. Herold;Nigel Bourne;Daniel Marcellino;Risa Kirkpatrick

  • Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations.

    Min Kyung Yi;Xiao Tong;Angela Skelton;Robert Chase

  • DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2

    Nigel Bourne;Gregg N. Milligan;Mark R. Schleiss;David I. Bernstein

  • Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease

    Xavier J. Da Costa;Nigel Bourne;Lawrence R. Stanberry;David M. Knipe

  • Effect of Passive Antibody on Congenital Cytomegalovirus Infection in Guinea Pigs

    Denise F. Bratcher;Nigel Bourne;Fernando J. Bravo;Mark R. Schleiss

  • Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs.

    Philip R. Krause;Lawrence R. Stanberry;Nigel Bourne;Beverly Connelly

  • Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

    Unknown

  • Construction and characterization of a second-generation pseudoinfectious West Nile virus vaccine propagated using a new cultivation system.

    Douglas G. Widman;Tomohiro Ishikawa;Rafik Fayzulin;Nigel Bourne

  • The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)

    Alexander S. Shavkunov;Norelle C. Wildburger;Miroslav N. Nenov;Thomas F. James

  • A Lethal Murine Infection Model for Dengue Virus 3 in AG129 Mice Deficient in Type I and II Interferon Receptors Leads to Systemic Disease

    Vanessa V. Sarathy;Mellodee White;Li Li;Summer R. Gorder

  • The Topical Microbicide PRO 2000 Protects against Genital Herpes Infection in a Mouse Model

    Nigel Bourne;David I. Bernstein;James Ireland;Andrew J. Sonderfan

  • Impact of Immunization with Glycoprotein D2/AS04 on Herpes Simplex Virus Type 2 Shedding into the Genital Tract in Guinea Pigs That Become Infected

    Nigel Bourne;Gregg N. Milligan;Lawrence R. Stanberry;Rachael Stegall

Frequent Co-Authors

David I. Bernstein
David I. Bernstein University of Cincinnati
Peter W. Mason
Peter W. Mason Novartis (Switzerland)
Alan D.T. Barrett
Alan D.T. Barrett The University of Texas Medical Branch at Galveston
Mark R. Schleiss
Mark R. Schleiss University of Minnesota
Stanley M. Lemon
Stanley M. Lemon University of North Carolina at Chapel Hill
Timothy M. Block
Timothy M. Block Drexel University
Pei-Yong Shi
Pei-Yong Shi GlaxoSmithKline (United Kingdom)
Robert M. Moriarty
Robert M. Moriarty University of Illinois at Chicago
Eva Harris
Eva Harris University of California, Berkeley
Ju-Tao Guo
Ju-Tao Guo Drexel University

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