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Biology and Biochemistry

D-Index
58
Citations
11177
World Ranking
13262
National Ranking
5647

Overview

Jeffrey W. Taub is affiliated with Wayne State University in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in the subfields of Molecular Biology, Hematology, Oncology, Genetics, and Pediatrics, Perinatology and Child Health.

The main topics covered in Taub's work include Acute Myeloid Leukemia Research, Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, Chronic Myeloid Leukemia Treatments, Acute Lymphoblastic Leukemia research, Childhood Cancer Survivors' Quality of Life, and Cancer therapeutics and mechanisms.

Taub has published extensively in a range of academic journals, most notably in Blood with eight publications, followed by Biochemical Pharmacology with seven, Pediatric Blood & Cancer with six, Cancer Research with four, and Signal Transduction and Targeted Therapy with two publications.

Frequent collaborators include Yubin Ge, Holly Edwards, Jenna L. Carter, Yongwei Su, and Maik Hüttemann, with which Taub has coauthored multiple papers.

Representative recent papers authored or coauthored by Taub are:

  • Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy, 2020, Signal Transduction and Targeted Therapy
  • Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia, 2020, Signal Transduction and Targeted Therapy
  • The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia, 2020, Haematologica
  • Targeting mitochondrial respiration for the treatment of acute myeloid leukemia, 2020, Biochemical Pharmacology
  • Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation, 2020, Cancers

Best Publications

  • Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial

    Jeffrey E. Rubnitz;Hiroto Inaba;Gary Dahl;Raul C. Ribeiro

  • Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin.

    Jeffrey W. Taub;Xi Huang;Larry H. Matherly;Mark L. Stout

  • Comparative Analysis of Different Approaches to Measure Treatment Response in Acute Myeloid Leukemia

    Hiroto Inaba;Elaine Coustan-Smith;Xueyuan Cao;Stanley B. Pounds

  • New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.

    Eric C. Hales;Jeffrey W. Taub;Larry H. Matherly

  • Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells.

    Xiaojia Niu;Jianyun Zhao;Jun Ma;Chengzhi Xie

  • Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia.

    Jeffrey W. Taub;Larry H. Matherly;Mark L. Stout;Steven A. Buck

  • The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

    A Larson Gedman;Q Chen;S Kugel Desmoulin;Y Ge

  • A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics.

    Tristan Knight;Daniel Luedtke;Holly Edwards;Jeffrey W Taub

  • Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL

    Qiang Wen;Benjamin Goldenson;Serena J. Silver;Monica Schenone

  • Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy

    Jenna L. Carter;Katie Hege;Jay Yang;Hasini A. Kalpage

  • Down Syndrome and Malignancies: A Unique Clinical Relationship: A Paper from the 2008 William Beaumont Hospital Symposium on Molecular Pathology

    Ana C. Xavier;Yubin Ge;Jeffrey W. Taub;Jeffrey W. Taub

  • High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia.

    Jeffrey W. Taub;Mark A. Konrad;Yubin Ge;John M. Naber

  • Down syndrome, drug metabolism and chromosome 21

    Jeffrey W. Taub;Yubin Ge

  • Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

    Maurice Labuhn;Kelly Perkins;Sören Matzk;Sören Matzk;Leila Varghese

  • Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-mutated Acute Myeloid Leukemia

    Jun Ma;Shoujing Zhao;Xinan Qiao;Tristan Knight;Tristan Knight

  • GATA1, Cytidine Deaminase, and the High Cure Rate of Down Syndrome Children With Acute Megakaryocytic Leukemia

    Yubin Ge;Mark L. Stout;Dana A. Tatman;Tanya L. Jensen

  • Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia : Relationship to immunophenotype and ploidy

    Long Zhang;Jeffrey W. Taub;Michael Williamson;So C. Wong

  • Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

    Daniel A Luedtke;Xiaojia Niu;Yihang Pan;Jianyun Zhao;Jianyun Zhao

  • Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome

    Jeffrey W. Taub;Gina Mundschau;Yubin Ge;Janet M. Poulik

  • Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia

    Yubin Ge;Alan A. Dombkowski;Katherine M. LaFiura;Dana Tatman

Frequent Co-Authors

Larry H. Matherly
Larry H. Matherly Wayne State University
Jeffrey E. Rubnitz
Jeffrey E. Rubnitz St. Jude Children's Research Hospital
Ching-Hon Pui
Ching-Hon Pui St. Jude Children's Research Hospital
Raul C. Ribeiro
Raul C. Ribeiro St. Jude Children's Research Hospital
Terrance L. Albrecht
Terrance L. Albrecht Wayne State University
Susana C. Raimondi
Susana C. Raimondi St. Jude Children's Research Hospital
John D. Crispino
John D. Crispino Northwestern University
Elaine Coustan-Smith
Elaine Coustan-Smith National University of Singapore
Louis A. Penner
Louis A. Penner Wayne State University
Sean Phipps
Sean Phipps St. Jude Children's Research Hospital

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