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Biology and Biochemistry

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91
Citations
52772
World Ranking
2267
National Ranking
1216

Medicine

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91
Citations
52876
World Ranking
11510
National Ranking
5902

Overview

Norman E. Sharpless is affiliated with the National Institutes of Health in the United States. Their research primarily covers the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these domains, their work spans several subfields, including Molecular Biology, Oncology, Infectious Diseases, Cancer Research, and Pulmonary and Respiratory Medicine.

Their main research topics focus on Melanoma and MAPK Pathways, Lung Cancer Treatments and Mutations, Cancer Genomics and Diagnostics, Telomeres, Telomerase, and Senescence, as well as SARS-CoV-2 and COVID-19 Research, including SARS-CoV-2 detection and testing.

Norman E. Sharpless has contributed to various publication venues with the highest number of works appearing in UNC Libraries, followed by bioRxiv (Cold Spring Harbor Laboratory), Cell, Journal of Clinical Oncology, and Cancer Cell.

Frequent co-authors in their research collaborations include:

  • Kwok-Kin Wong (13 publications)
  • Chad Torrice (11 publications)
  • Janakiraman Krishnamurthy (10 publications)
  • Christin E. Burd (10 publications)
  • David B. Darr (9 publications)

Selected recent papers authored or co-authored by Norman E. Sharpless include:

  • "COVID-19 and cancer" (2020) published in Science
  • "Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy" (2021) published in JNCI Journal of the National Cancer Institute
  • "Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection" (2021) published in JAMA Internal Medicine
  • "A Blueprint for Characterizing Senescence" (2020) published in Cell
  • "Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice" (2020) published in UNC Libraries

Best Publications

  • Circular RNAs are abundant, conserved, and associated with ALU repeats

    William R. Jeck;Jessica A. Sorrentino;Kai Wang;Michael K. Slevin

  • Genomic Classification of Cutaneous Melanoma

    Rehan Akbani;Kadir C. Akdemir;B. Arman Aksoy;Monique Albert

  • Detecting and characterizing circular RNAs

    William R Jeck;Norman E Sharpless

  • Ink4a/Arf expression is a biomarker of aging

    Janakiraman Krishnamurthy;Chad Torrice;Matthew R. Ramsey;Grigoriy I. Kovalev

  • Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

    Jianhui Chang;Yingying Wang;Yingying Wang;Lijian Shao;Remi Martin Laberge

  • Senescence in Health and Disease

    Shenghui He;Norman E. Sharpless

  • Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

    Viktor Janzen;Randolf Forkert;Heather E. Fleming;Yoriko Saito

  • LKB1 modulates lung cancer differentiation and metastasis

    Hongbin Ji;Matthew R. Ramsey;D. Neil Hayes;Cheng Fan

  • Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.

    Norman E. Sharpless;Nabeel Bardeesy;Kee Ho Lee;Daniel Carrasco

  • The regulation of INK4/ARF in cancer and aging.

    William Y. Kim;Norman E. Sharpless

  • Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

    Marco Demaria;Marco Demaria;Monique N. O'Leary;Jianhui Chang;Lijian Shao

  • Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

    Anna V. Molofsky;Shalom G. Slutsky;Nancy M. Joseph;Shenghui He

  • p16INK4a induces an age-dependent decline in islet regenerative potential.

    Janakiraman Krishnamurthy;Matthew R. Ramsey;Keith L. Ligon;Chad Torrice

  • How stem cells age and why this makes us grow old.

    Norman E. Sharpless;Ronald A. DePinho

  • Forging a signature of in vivo senescence

    Norman E. Sharpless;Charles J. Sherr

  • Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

    Christin E. Burd;William R. Jeck;Yan Liu;Hanna K. Sanoff

  • Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

    James S. Duncan;Martin C. Whittle;Kazuhiro Nakamura;Amy N. Abell

  • Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

    Robert M Bachoo;Elizabeth A Maher;Keith L Ligon;Norman E Sharpless

  • The mighty mouse: genetically engineered mouse models in cancer drug development

    Norman E. Sharpless;Ronald A. DePinho

  • The INK4A/ARF locus and its two gene products.

    Norman E Sharpless;Ronald A DePinho

Frequent Co-Authors

Kwok-Kin Wong
Kwok-Kin Wong New York University
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
James E. Bear
James E. Bear University of North Carolina at Chapel Hill
Nabeel Bardeesy
Nabeel Bardeesy Harvard University
Joel S. Parker
Joel S. Parker University of North Carolina at Chapel Hill
Diego H. Castrillon
Diego H. Castrillon The University of Texas Southwestern Medical Center
Charles M. Perou
Charles M. Perou University of North Carolina at Chapel Hill
Geoffrey I. Shapiro
Geoffrey I. Shapiro Harvard University
Hongbin Ji
Hongbin Ji Chinese Academy of Sciences
H. Shelton Earp
H. Shelton Earp University of North Carolina at Chapel Hill

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