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Biology and Biochemistry

D-Index
79
Citations
30747
World Ranking
4223
National Ranking
2067

Overview

H. Shelton Earp is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans multiple areas within medicine, biochemistry, genetics, molecular biology, immunology, and microbiology.

Their scientific output includes significant contributions across various subfields such as immunology, molecular biology, oncology, genetics, and cancer research. The main topics of their work focus on phagocytosis and immune regulation, HER2/EGFR in cancer research, protein degradation and inhibitors, breast cancer treatment studies, research on monoclonal and polyclonal antibodies, cell death mechanisms and regulation, and autophagy in disease and therapy.

Frequent coauthors collaborating with H. Shelton Earp include:

  • Douglas K. Graham
  • Deborah DeRyckere
  • Stephen V. Frye
  • Xiaodong Wang
  • Justus M. Huelse

Common publication venues for their work are:

  • UNC Libraries
  • Cancer Research
  • Cancer Immunology Research
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent papers authored or coauthored by H. Shelton Earp highlight their focus on cancer biology and immunology:

  • Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk, 2020, JNCI Journal of the National Cancer Institute
  • TAM family kinases as therapeutic targets at the interface of cancer and immunity, 2023, Nature Reviews Clinical Oncology
  • TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability, 2022, Autophagy
  • Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer, 2021, Nucleic Acids Research
  • MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer, 2022, Journal of Clinical Investigation

Best Publications

  • Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study.

    Lisa A. Carey;Charles M. Perou;Chad A. Livasy;Lynn G. Dressler

  • Phagocytosis and clearance of apoptotic cells is mediated by MER.

    Rona S. Scott;Eileen J. McMahon;Shannon M. Pop;Elizabeth A. Reap

  • Epidemiology of basal-like breast cancer

    Robert C. Millikan;Beth Newman;Chiu Kit Tse;Patricia G. Moorman

  • Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

    L Kornberg;H S Earp;J T Parsons;M Schaller

  • Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

    L J Kornberg;H S Earp;C E Turner;C Prockop

  • Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

    James S. Duncan;Martin C. Whittle;Kazuhiro Nakamura;Amy N. Abell

  • TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer

    Rachel M A Linger;Amy K Keating;H Shelton Earp;Douglas K Graham

  • Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase.

    Philip L. Cohen;Roberto Caricchio;Valsamma Abraham;Todd D. Camenisch

  • The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

    Sharon T. Wong;Lisa F. Winchell;Bryan K. McCune;H.Shelton Earp

  • The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer

    Douglas K. Graham;Deborah DeRyckere;Kurtis D. Davies;H. Shelton Earp

  • Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

    Qingxian Lu;Martin Gore;Martin Gore;Qing Zhang;Todd Camenisch

  • Macrophages and Dendritic Cells Use Different Axl/Mertk/Tyro3 Receptors in Clearance of Apoptotic Cells

    Heather M. Seitz;Todd D. Camenisch;Greg Lemke;H. Shelton Earp

  • The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor.

    W E Miller;H S Earp;N Raab-Traub

  • Activation of a Novel Calcium-dependent Protein-tyrosine Kinase CORRELATION WITH c-Jun N-TERMINAL KINASE BUT NOT MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION

    Hong Yu;Xiong Li;Gail S. Marchetto;Ruth Dy

  • Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

    Anne Angelillo-Scherrer;Laurent Burnier;Nathalie Flores;Pierre Savi

  • Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.

    Nupam P. Mahajan;Yuanbo Liu;Samarpan Majumder;Maria R. Warren

  • Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains

    Timothy J. Stuhlmiller;Samantha M. Miller;Jon S. Zawistowski;Kazuhiro Nakamura

  • Regulation of carbamoyl phosphate synthetase by MAP kinase.

    Lee M. Graves;Hedeel I. Guy;Piotr Kozlowski;Min Huang

  • Activated Tyrosine Kinase Ack1 Promotes Prostate Tumorigenesis: Role of Ack1 in Polyubiquitination of Tumor Suppressor Wwox

    Nupam P. Mahajan;Young E. Whang;James L. Mohler;H. Shelton Earp

  • Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane

    Philip L. Cohen;Roberto Caricchio;Valsamma Abraham;Todd D. Camenisch

Frequent Co-Authors

Stephen V. Frye
Stephen V. Frye University of North Carolina at Chapel Hill
Glenn K. Matsushima
Glenn K. Matsushima University of North Carolina at Chapel Hill
Lee M. Graves
Lee M. Graves University of North Carolina at Chapel Hill
Charles M. Perou
Charles M. Perou University of North Carolina at Chapel Hill
Joel S. Parker
Joel S. Parker University of North Carolina at Chapel Hill
Lisa A. Carey
Lisa A. Carey University of North Carolina at Chapel Hill
Gary L. Johnson
Gary L. Johnson University of North Carolina at Chapel Hill
Andrew F. Olshan
Andrew F. Olshan University of North Carolina at Chapel Hill
Norman E. Sharpless
Norman E. Sharpless National Institutes of Health
Mischa Machius
Mischa Machius The University of Texas Southwestern Medical Center

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