Stephen V. Frye

Overview

Best Publications

• Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

  Wei Xu;Hui Yang;Ying Liu;Ying Yang

  2967
  Citations

• The promise and peril of chemical probes.

  Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

  883
  Citations

• Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

  James S. Duncan;Martin C. Whittle;Kazuhiro Nakamura;Amy N. Abell

  850
  Citations

• A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

  Masoud Vedadi;Dalia Barsyte-Lovejoy;Feng Liu;Sylvie Rival-Gervier

  608
  Citations

• An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

  Kyle D. Konze;Anqi Ma;Fengling Li;Dalia Barsyte-Lovejoy

  477
  Citations

• Too many roads not taken

  Aled M Edwards;Ruth Isserlin;Gary D Bader;Stephen V Frye

  458
  Citations

• The art of the chemical probe

  Stephen V Frye

  447
  Citations

• Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

  John A. Allen;Julianne M. Yost;Vincent Setola;Xin Chen

  398
  Citations

• The human genome and drug discovery after a decade. Roads (still) not taken

  Ruth Isserlin;Gary D. Bader;Aled Edwards;Stephen Frye

  367
  Citations

• Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

  H.N. Bramson;J. Corona;S.T. Davis;S.H. Dickerson

  328
  Citations

• The discovery of potent cRaf1 kinase inhibitors

  Karen Lackey;Michael Cory;Ronda Davis;Stephen V. Frye

  286
  Citations

• Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

  Feng Liu;Dalia Barsyte-Lovejoy;Fengling Li;Yan Xiong

  264
  Citations

• Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

  Bret D. Wallace;Adam B. Roberts;Rebecca M. Pollet;James D. Ingle

  254
  Citations

• Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

  Feng Liu;Xin Chen;Abdellah Allali-Hassani;Amy M. Quinn

  244
  Citations

• Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.

  Stephen T. Davis;Bill G. Benson;H. Neal Bramson;Dennis E. Chapman

  242
  Citations

• Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

  Bowen Xu;Doan M. On;Anqi Ma;Trevor Parton

  235
  Citations

• Protein lysine methyltransferase g9a inhibitors: Design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

  Feng Liu;Xin Chen;Abdellah Allali-Hassani;Amy M. Quinn

  224
  Citations

• Chelates as intermediates in nucleophilic additions to alkoxy ketones according to Cram's rule (cyclic model)

  Xiangning Chen;Edwin R. Hortelano;Ernest L. Eliel;Stephen V. Frye

  191
  Citations

• Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR

  H N Bramson;D Hermann;K W Batchelor;F W Lee

  190
  Citations

• Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

  Lindsey I. James;Dalia Barsyte-Lovejoy;Nan Zhong;Liubov Krichevsky

  189
  Citations