His scientific interests lie mostly in Nuclear receptor, Peroxisome proliferator-activated receptor, Biochemistry, Receptor and Internal medicine. His Nuclear receptor research incorporates elements of Signal transduction, Cell biology and Orphan receptor. His work deals with themes such as Cancer research, Transcription factor, Glucose homeostasis, Adipogenesis and Peroxisome proliferator-activated receptor alpha, which intersect with Peroxisome proliferator-activated receptor.
His Receptor study incorporates themes from Homeostasis, Bioinformatics, Drug discovery, Peroxisome proliferator-activated receptor delta and Fibrate. His studies deal with areas such as Liver X receptor and Endocrinology as well as Internal medicine. His work on Hepatic stellate cell as part of general Endocrinology research is often related to Hepatic stellate cell activation, thus linking different fields of science.
His primary areas of study are Nuclear receptor, Biochemistry, Receptor, Peroxisome proliferator-activated receptor and Stereochemistry. He has researched Nuclear receptor in several fields, including Orphan receptor and Cell biology. His Receptor study integrates concerns from other disciplines, such as Gene expression, Fibrate and Small molecule.
Peroxisome proliferator-activated receptor is a subfield of Internal medicine that Timothy M. Willson investigates. His biological study spans a wide range of topics, including Chemical synthesis and Ring. His Endocrinology research integrates issues from Cancer research and Peroxisome proliferator-activated receptor gamma.
His primary areas of investigation include Kinase, Computational biology, Cell biology, Drug discovery and Kinome. The subject of his Kinase research is within the realm of Biochemistry. Timothy M. Willson integrates Biochemistry with NAK in his research.
His work carried out in the field of Cell biology brings together such families of science as Tissue homeostasis and Receptor-mediated endocytosis. His work is dedicated to discovering how Kinome, Druggability are connected with Bromodomain, Transcription, Molecular biology, Transcription factor and Scaffold protein and other disciplines. The various areas that he examines in his Protein kinase A study include Cancer cell, Receptor, Angiogenesis and Recombinant DNA.
Timothy M. Willson spends much of his time researching Kinase, Cell biology, Biochemistry, Kinome and Drug discovery. The Kinase study combines topics in areas such as Chemical probe and In vitro. His Cell biology research includes themes of Chemokine, Innate immune system and Circadian clock, Circadian rhythm.
His Biochemistry study frequently links to adjacent areas such as Thiadiazoles. His Kinome study combines topics in areas such as Regulator, Entry into host and Subfamily. His Drug discovery research incorporates themes from Angiogenesis, Recombinant DNA, Cancer cell, Receptor and Computational biology.
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann;Linda B. Moore;Tracey A. Smith-Oliver;William O. Wilkison.
Journal of Biological Chemistry (1995)
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Mercedes Ricote;Andrew C. Li;Andrew C. Li;Timothy M. Willson;Carolyn J. Kelly.
Nature (1998)
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Steven A. Kliewer;Scott S. Sundseth;Stacey A. Jones;Peter J. Brown.
Proceedings of the National Academy of Sciences of the United States of America (1997)
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Steven A. Kliewer;James M. Lenhard;Timothy M. Willson;Inder Patel.
Cell (1995)
The PPARs: from orphan receptors to drug discovery.
Timothy M. Willson;Peter J. Brown;Daniel D. Sternbach;Brad R. Henke.
Journal of Medicinal Chemistry (2000)
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
R T Nolte;G B Wisely;S Westin;J E Cobb.
Nature (1998)
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Derek J. Parks;Steven G. Blanchard;Randy K. Bledsoe;Gyan Chandra.
Science (1999)
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Bryan Goodwin;Stacey A. Jones;Roger R. Price;Michael A. Watson.
Molecular Cell (2000)
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
Jürgen M. Lehmann;David D. McKee;Michael A. Watson;Timothy M. Willson.
Journal of Clinical Investigation (1998)
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Steven A Kliewer;John T Moore;Laura Wade;Jeff L Staudinger.
Cell (1998)
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