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Biology and Biochemistry

D-Index
71
Citations
18337
World Ranking
6636
National Ranking
437

Overview

Mamoru Ito is affiliated with the Central Institute for Experimental Animals in Japan. Their research spans multiple disciplines within the biomedical sciences, focusing on medicine, immunology and microbiology, as well as biochemistry, genetics, and molecular biology.

The main research areas covered by Mamoru Ito include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Cancer Immunotherapy and Biomarkers
  • Immune cells in cancer
  • Cancer Research and Treatments
  • Diet and metabolism studies

They have contributed notably to immunology, oncology, molecular biology, physiology, and public health, environmental, and occupational health. Immunology is particularly prominent among their subfields, alongside oncology and molecular biology.

Mamoru Ito has published extensively in several journals, with frequent contributions to:

  • Scientific Reports
  • Journal of Thoracic Oncology
  • Cancer Science
  • Research Square
  • Cancer Research

Recent published papers include:

  1. BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial-Mesenchymal Transition (2020, Cancer Research)
  2. Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells (2021, Science Advances)
  3. DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions (2021, Proceedings of the National Academy of Sciences)
  4. Thrombin cleavage of osteopontin initiates osteopontin's tumor-promoting activity (2022, Journal of Thrombosis and Haemostasis)
  5. Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer (2024, Nature Communications)

The scientist frequently collaborates with several coauthors, including:

  • Ryoji Ito
  • Ikumi Katano
  • Motohito Goto
  • Riichi Takahashi
  • Yusuke Ohno

Best Publications

  • NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

    Mamoru Ito;Hidefumi Hiramatsu;Kimio Kobayashi;Kazutomo Suzue

  • Generation of transgenic non-human primates with germline transmission

    Erika Sasaki;Hiroshi Suemizu;Akiko Shimada;Kisaburo Hanazawa

  • Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells.

    Toshiaki Ohteki;Taro Fukao;Kazutomo Suzue;Chikako Maki

  • Current advances in humanized mouse models

    Ryoji Ito;Takeshi Takahashi;Ikumi Katano;Mamoru Ito

  • A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord

    Shinjiro Kaneko;Akio Iwanami;Masaya Nakamura;Akiyoshi Kishino

  • Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor

    Takahiro Ueda;Kohichiro Tsuji;Hiroshi Yoshino;Yasuhiro Ebihara

  • Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment.

    Yukari Muguruma;Takashi Yahata;Takashi Yahata;Hiroko Miyatake;Hiroko Miyatake;Tadayuki Sato;Tadayuki Sato

  • Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model

    Hidefumi Hiramatsu;Ryuta Nishikomori;Ryuta Nishikomori;Toshio Heike;Toshio Heike;Mamoru Ito;Mamoru Ito

  • The Reconstituted ‘Humanized Liver’ in TK-NOG Mice is Mature and Functional

    Masami Hasegawa;Kenji Kawai;Tetsuya Mitsui;Kenji Taniguchi;Kenji Taniguchi

  • Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells.

    Takashi Yahata;Tomomi Takanashi;Yukari Muguruma;Abd Aziz Ibrahim

  • Stem Cell-Like Properties of the Endometrial Side Population: Implication in Endometrial Regeneration

    Hirotaka Masuda;Yumi Matsuzaki;Emi Hiratsu;Masanori Ono

  • Cloned Mice from Fetal Fibroblast Cells Arrested at Metaphase by a Serial Nuclear Transfer

    Yukiko Ono;Nobuhiro Shimozawa;Nobuhiro Shimozawa;Mamoru Ito;Tomohiro Kono

  • Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

    Satoru Watanabe;Kazuo Terashima;Shinrai Ohta;Shigeo Horibata

  • The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG) mice (hu-HSC NOG mice)

    Yohei Watanabe;Takeshi Takahashi;Akira Okajima;Miho Shiokawa

  • A New Humanized Mouse Model of Epstein-Barr Virus Infection That Reproduces Persistent Infection, Lymphoproliferative Disorder, and Cell-Mediated and Humoral Immune Responses

    Misako Yajima;Ken-Ichi Imadome;Atsuko Nakagawa;Satoru Watanabe

  • Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells

    Masanori Ono;Tetsuo Maruyama;Hirotaka Masuda;Takashi Kajitani

  • Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/γcnull immunodeficient mice

    Hirotaka Masuda;Tetsuo Maruyama;Emi Hiratsu;Junichi Yamane

  • Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12.

    Tomohiro Kodama;Kazuyoshi Takeda;Osamu Shimozato;Yoshihiro Hayakawa

  • Stimulation of Mouse and Human Primitive Hematopoiesis by Murine Embryonic Aorta-Gonad-Mesonephros–Derived Stromal Cell Lines

    Ming Jiang Xu;Kohichiro Tsuji;Kohichiro Tsuji;Takahiro Ueda;Takahiro Ueda;Yoh Suke Mukouyama;Yoh Suke Mukouyama

  • CD27-mediated activation of murine NK cells.

    Kazuyoshi Takeda;Hideo Oshima;Hideo Oshima;Yoshihiro Hayakawa;Hisaya Akiba

Frequent Co-Authors

Tatsutoshi Nakahata
Tatsutoshi Nakahata Kyoto University
Naoki Yamamoto
Naoki Yamamoto Kyoto University
Yoshio Koyanagi
Yoshio Koyanagi Kyoto University
Sonoko Habu
Sonoko Habu Juntendo University
Kohichiro Tsuji
Kohichiro Tsuji University of Tokyo
Yuzaburo Oku
Yuzaburo Oku Tottori University
Hideyuki Okano
Hideyuki Okano Keio University
Toshio Heike
Toshio Heike Kyoto University
Yasuo Ikeda
Yasuo Ikeda Waseda University
Hideo Yagita
Hideo Yagita Juntendo University

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