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Biology and Biochemistry

D-Index
86
Citations
25930
World Ranking
2972
National Ranking
221

Research.com Recognitions

  • 2014 - Fellow of the Royal Society of Edinburgh
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Laura M. Machesky is affiliated with the University of Glasgow in the United Kingdom and has a research focus spanning biochemistry, genetics, molecular biology, and medicine.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, subfields addressed by their work cover:

  • Cell Biology
  • Molecular Biology
  • Biophysics
  • Immunology and Allergy
  • Biomedical Engineering

The main research topics explored involve:

  • Cellular Mechanics and Interactions
  • Cell Adhesion Molecules Research
  • Advanced Fluorescence Microscopy Techniques
  • Cellular transport and secretion
  • Advanced Optical Sensing Technologies
  • Retinal Development and Disorders
  • Cancer Cells and Metastasis

Frequent publication venues for their research include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • The Journal of Cell Biology
  • Nature Cell Biology
  • Current Opinion in Cell Biology

Some recent papers authored or co-authored by Laura M. Machesky are:

  • Deadly actin collapse by disulfidptosis, 2023, Nature Cell Biology
  • The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis, 2020, Nature Metabolism
  • Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown, 2020, Science
  • The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces, 2020, Current Opinion in Cell Biology
  • Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation, 2020, Scientific Reports

Frequent co-authors who have collaborated extensively with Laura M. Machesky include:

  • Robert H. Insall
  • Jamie Whitelaw
  • Nikki R. Paul
  • Daniele Faccio
  • Heather J. Spence

The scientist has been recognized with several awards and honors, including:

  • Fellow of the Royal Society of Edinburgh (2014)
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom

Best Publications

  • Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

    Laura M. Machesky;Robert H. Insall

  • Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex.

    Machesky Lm;Mullins Rd;Higgs Hn;Kaiser Da

  • The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

    Vania M.M. Braga;Laura M. Machesky;Alan Hall;Neil A. Hotchin

  • Phagocytosis and the actin cytoskeleton

    Robin C. May;Laura M. Machesky

  • Purification of a Cortical Complex Containing Two Unconventional Actins from Acanthamoeba by Affinity Chromatography on Profilin-Agarose

    Laura M Machesky;Simon J Atkinson;Christophe Ampe;Joel Vandekerckhove

  • Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation.

    Pascal J. Goldschmidt-Clermont;Jae Won Kim;Laura M. Machesky;Sue Goo Rhee

  • Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3

    A.L. Rozelle;L.M. Machesky;M. Yamamoto;M.H.E. Driessens

  • The Actin-Binding Protein Profilin Binds to PIP2 and Inhibits Its Hydrolysis by Phospholipase C

    Pascal J. Goldschmidt-Clermont;Laura M. Machesky;Joseph J. Baldassare;Thomas D. Pollard

  • Actin dynamics at the leading edge: from simple machinery to complex networks.

    Robert H. Insall;Laura M. Machesky

  • Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization

    Laura M. Machesky;Alan Hall

  • Rab27a is required for regulated secretion in cytotoxic T lymphocytes.

    Jane C. Stinchcombe;Duarte C. Barral;Emilie H. Mules;Sarah Booth

  • The Arp2/3 complex: a multifunctional actin organizer.

    Laura M Machesky;Kathleen L Gould

  • Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.

    Robin C. May;Emmanuelle Caron;Alan Hall;Laura M. Machesky

  • Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.

    Thomas H. Millard;Stewart J. Sharp;Laura M. Machesky

  • Rho: a connection between membrane receptor signalling and the cytoskeleton.

    Laura M. Machesky;Alan Hall

  • Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.

    Siobhan Burns;Adrian J. Thrasher;Michael P. Blundell;Laura Machesky

  • Lamellipodia and filopodia in metastasis and invasion.

    Laura M. Machesky

  • Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

    Vania M.M. Braga;Aldo Del Maschio;Laura Machesky;Elisabetta Dejana

  • Signaling to actin dynamics.

    Laura M. Machesky;Robert H. Insall

  • The actin bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion

    Ang Li;John C. Dawson;Manuel Forero-Vargas;Heather J. Spence

Frequent Co-Authors

Robert H. Insall
Robert H. Insall University of Glasgow
Owen J. Sansom
Owen J. Sansom University of Glasgow
Thomas D. Pollard
Thomas D. Pollard Yale University
Steve P. Watson
Steve P. Watson University of Birmingham
Robin C. May
Robin C. May University of Birmingham
Owen J. T. McCarty
Owen J. T. McCarty Oregon Health & Science University
Kurt I. Anderson
Kurt I. Anderson The Francis Crick Institute
Daniele Faccio
Daniele Faccio University of Glasgow
Colin Nixon
Colin Nixon University of Glasgow
Jim C. Norman
Jim C. Norman University of Glasgow

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