D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 83 Citations 31,404 275 World Ranking 1489 National Ranking 95
Medicine D-index 84 Citations 21,958 266 World Ranking 7830 National Ranking 722

Research.com Recognitions

Awards & Achievements

2012 - Fellow of the Royal Society of Edinburgh

Fellow of The Academy of Medical Sciences, United Kingdom

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Enzyme

Owen J. Sansom mainly investigates Cancer research, Cell biology, Stem cell, Carcinogenesis and Signal transduction. His research integrates issues of Cell culture, Pancreatic cancer, Immunology, Metastasis and PI3K/AKT/mTOR pathway in his study of Cancer research. His Immunology research includes themes of Cancer and Colorectal cancer.

His Cell biology study integrates concerns from other disciplines, such as Cell, Integrin, Cell cycle, Cellular differentiation and Cancer cell. His study in Stem cell is interdisciplinary in nature, drawing from both Adenomatous polyposis coli and Adult stem cell. As a member of one scientific family, Owen J. Sansom mostly works in the field of Carcinogenesis, focusing on Protein kinase B and, on occasion, Oncogene.

His most cited work include:

  • Crypt stem cells as the cells-of-origin of intestinal cancer (1583 citations)
  • Genomic analyses identify molecular subtypes of pancreatic cancer (1396 citations)
  • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs (1316 citations)

What are the main themes of his work throughout his whole career to date?

Owen J. Sansom spends much of his time researching Cancer research, Cell biology, Wnt signaling pathway, Carcinogenesis and Stem cell. His studies deal with areas such as Cancer, Colorectal cancer, Pancreatic cancer, Immunology and Signal transduction as well as Cancer research. His Pancreatic cancer study combines topics from a wide range of disciplines, such as KRAS, Metastasis, Pancreas and Pathology.

His Cell biology study combines topics in areas such as Cancer cell, Cell and Cellular differentiation. He has included themes like Molecular biology, Adenomatous polyposis coli and Intestinal epithelium in his Wnt signaling pathway study. His study explores the link between Carcinogenesis and topics such as Apoptosis that cross with problems in In vivo.

He most often published in these fields:

  • Cancer research (55.28%)
  • Cell biology (26.97%)
  • Wnt signaling pathway (20.00%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cancer research (55.28%)
  • Cell biology (26.97%)
  • Wnt signaling pathway (20.00%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cancer research, Cell biology, Wnt signaling pathway, Colorectal cancer and Stem cell. His Cancer research research incorporates elements of Carcinogenesis, Cancer, Pancreatic cancer, Cell growth and Downregulation and upregulation. The study incorporates disciplines such as Metabolism and Protein biosynthesis in addition to Cell biology.

His Wnt signaling pathway research is multidisciplinary, incorporating perspectives in Cancer stem cell, Homeostasis and MAPK/ERK pathway. His Colorectal cancer research incorporates themes from Epidermal growth factor receptor, Oncology and Phosphorylation. The Stem cell study which covers Tissue homeostasis that intersects with RALA.

Between 2017 and 2021, his most popular works were:

  • Patient-derived organoids model treatment response of metastatic gastrointestinal cancers (482 citations)
  • Mannose impairs tumour growth and enhances chemotherapy (95 citations)
  • CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype. (77 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Enzyme

His main research concerns Cancer research, Pancreatic cancer, Cell biology, Cancer and Cell growth. His Cancer research research integrates issues from Hypoxia, Transcriptome, Downregulation and upregulation, Metastasis and Regeneration. The concepts of his Pancreatic cancer study are interwoven with issues in Phenotype, Reverse phase protein lysate microarray, Combination therapy and Immunotherapy.

His Cell biology research is multidisciplinary, incorporating elements of Regulation of gene expression and Protein biosynthesis. As part of the same scientific family, Owen J. Sansom usually focuses on Cancer, concentrating on Pancreas and intersecting with Blocking antibody and Survival rate. His Cell growth research is multidisciplinary, relying on both Gemcitabine and Cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Crypt stem cells as the cells-of-origin of intestinal cancer

Nick Barker;Rachel A. Ridgway;Johan H. Van Es;Marc Van De Wetering.
Nature (2009)

2031 Citations

Genomic analyses identify molecular subtypes of pancreatic cancer

Bailey P;Chang Dk;Nones K;Nones K;Johns Al.
Nature (2016)

1736 Citations

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

Ulrich Wellner;Jörg Schubert;Ulrike C Burk;Otto Schmalhofer.
Nature Cell Biology (2009)

1647 Citations

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Juan Carlos Acosta;Ana Banito;Torsten Wuestefeld;Athena Georgilis.
Nature Cell Biology (2013)

1062 Citations

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

Sarah Schwitalla;Alexander A. Fingerle;Patrizia Cammareri;Tim Nebelsiek.
Cell (2013)

864 Citations

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Owen J. Sansom;Karen Reed;Anthony Joseph Hayes;Heather Ireland.
Genes & Development (2004)

854 Citations

Mutant p53 Drives Invasion by Promoting Integrin Recycling

Patricia A.J. Muller;Patrick T. Caswell;Brendan Doyle;Marcin P. Iwanicki.
Cell (2009)

757 Citations

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

Luke Boulter;Olivier Govaere;Tom G Bird;Sorina Radulescu.
Nature Medicine (2012)

660 Citations

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

Javier Muñoz;Daniel E Stange;Arnout G Schepers;Marc van de Wetering.
The EMBO Journal (2012)

624 Citations

Myc deletion rescues Apc deficiency in the small intestine

Owen J. Sansom;Valerie Meniel;Vanesa Muncan;Toby Phesse.
Nature (2007)

600 Citations

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