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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
118
Citations
55536
World Ranking
697
National Ranking
37

Medicine

D-Index
117
Citations
55407
World Ranking
4186
National Ranking
409

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2012 - Fellow of the Royal Society of Edinburgh
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Owen J. Sansom is affiliated with the University of Glasgow in the United Kingdom. Their research spans extensively across medicine, with a particular focus on biochemistry, genetics, and molecular biology. The scientist's main fields of study include molecular biology, oncology, cancer research, immunology, and pathology and forensic medicine.

Their recent published work highlights a range of topics, such as cancer cells and metastasis, cancer genomics and diagnostics, colorectal cancer treatments and genetic factors, pancreatic and hepatic oncology research, as well as immune cells and immunotherapy in cancer. These themes situate their research at the intersection of cancer biology and therapeutic strategies.

Several recent papers illustrate their contributions:

  • The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer, 2021, Nature Genetics
  • Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity, 2021, Cancer Cell
  • Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy, 2021, Nature Communications
  • Therapeutic targeting of tumour myeloid cells, 2023, Nature Reviews. Cancer
  • NOTUM from Apc-mutant cells biases clonal competition to initiate cancer, 2021, Nature

Owen J. Sansom frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cancer Research, Cell Reports, and the Journal of Clinical Oncology. These journals reflect the concentration of their scholarly output in cancer and molecular biology research.

Frequent collaborators include Andrew D. Campbell, Colin Nixon, Kathryn Gilroy, Rachel A. Ridgway, and Joanne Edwards. These coauthors have published extensively alongside Owen J. Sansom, indicating ongoing research partnerships.

The scientist has been recognized as a Fellow of the Royal Society of Edinburgh since 2012 and is also a Fellow of The Academy of Medical Sciences in the United Kingdom. These honors denote affiliations with prestigious scholarly communities within medical and biological sciences.

Best Publications

  • Genomic analyses identify molecular subtypes of pancreatic cancer

    Bailey P;Chang Dk;Nones K;Nones K;Johns Al

  • Crypt stem cells as the cells-of-origin of intestinal cancer

    Nick Barker;Rachel A. Ridgway;Johan H. Van Es;Marc Van De Wetering

  • A complex secretory program orchestrated by the inflammasome controls paracrine senescence

    Juan Carlos Acosta;Ana Banito;Torsten Wuestefeld;Athena Georgilis

  • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

    Ulrich Wellner;Jörg Schubert;Ulrike C Burk;Otto Schmalhofer

  • Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

    Georgios Vlachogiannis;Somaieh Hedayat;Alexandra Vatsiou;Yann Jamin

  • Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

    Sarah Schwitalla;Alexander A. Fingerle;Patrizia Cammareri;Tim Nebelsiek

  • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

    Owen J. Sansom;Karen Reed;Anthony Joseph Hayes;Heather Ireland

  • Mutant p53 Drives Invasion by Promoting Integrin Recycling

    Patricia A.J. Muller;Patrick T. Caswell;Brendan Doyle;Marcin P. Iwanicki

  • The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

    Javier Muñoz;Daniel E Stange;Arnout G Schepers;Marc van de Wetering

  • Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

    Luke Boulter;Olivier Govaere;Tom G Bird;Sorina Radulescu

  • CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

    Colin W. Steele;Saadia A. Karim;Joshua D.G. Leach;Peter Bailey

  • p53 status determines the role of autophagy in pancreatic tumour development

    Mathias T. Rosenfeldt;Jim O’Prey;Jennifer P. Morton;Colin Nixon

  • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

    Jennifer P. Morton;Paul Timpson;Saadia A. Karim;Rachel A. Ridgway

  • Myc deletion rescues Apc deficiency in the small intestine

    Owen J. Sansom;Valerie Meniel;Vanesa Muncan;Toby Phesse

  • The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

    Birgit Ritschka;Mekayla Storer;Alba Mas;Florian Heinzmann

  • Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

    Michael S. Samuel;Jose I. Lopez;Ewan J. McGhee;Daniel R. Croft

  • Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

    Susanne Walz;Francesca Lorenzin;Jennifer Morton;Katrin E. Wiese

  • Modulating the therapeutic response of tumours to dietary serine and glycine starvation

    Oliver D. K. Maddocks;Dimitris Athineos;Eric C. Cheung;Pearl Lee

  • Hepatic progenitor cells of biliary origin with liver repopulation capacity

    Wei-Yu Lu;Thomas G. Bird;Luke Boulter;Atsunori Tsuchiya

  • Inducible cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin

    Heather Ireland;Richard Kemp;Carol Houghton;Louise Howard

Frequent Co-Authors

Jennifer P. Morton
Jennifer P. Morton University of Glasgow
Alan Richard Clarke
Alan Richard Clarke Cardiff University
Colin Nixon
Colin Nixon University of Glasgow
Paul Timpson
Paul Timpson Garvan Institute of Medical Research
Valerie G. Brunton
Valerie G. Brunton University of Edinburgh
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Kurt I. Anderson
Kurt I. Anderson The Francis Crick Institute
Karen Blyth
Karen Blyth University of Glasgow
Andrew V. Biankin
Andrew V. Biankin University of Glasgow
Stuart J. Forbes
Stuart J. Forbes University of Edinburgh

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