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Guillermo García-Cardeña

Guillermo García-Cardeña

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
30172
World Ranking
8936
National Ranking
3968

Overview

Guillermo García-Cardeña is affiliated with Brigham and Women's Hospital in the United States. Their research spans multiple aspects of molecular biology and medicine, with notable focus on cardiovascular medicine and related biomedical engineering. Their work encompasses areas such as cardiac fibrosis and remodeling, Kruppel-like factors research, angiogenesis and VEGF in cancer, single-cell and spatial transcriptomics, atherosclerosis and cardiovascular diseases, 3D printing in biomedical research, and congenital heart defects research.

The scientist has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine, with a strong emphasis on molecular biology and cardiology-related subfields. They have published across a variety of high-impact venues, including bioRxiv (Cold Spring Harbor Laboratory), SSRN Electronic Journal, Circulation, Atherosclerosis, and Blood Advances.

Recent significant papers authored or co-authored by Garcia-Cardeña include:

  • Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria, 2020, Blood Advances
  • Endothelial cell dysfunction in cardiac disease: driver or consequence?, 2023, Frontiers in Cell and Developmental Biology
  • Engineering microvascular networks using a KLF2 reporter to probe flow-dependent endothelial cell function, 2024, Biomaterials
  • Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease, 2024, Cell Reports Medicine
  • Fibroblast activation in response to TGFβ1 is modulated by co-culture with endothelial cells in a vascular organ-on-chip platform, 2023, Frontiers in Molecular Biosciences

Frequent collaborators in their research include Adriana Blazeski, Elamaran Meibalan, Eloi Schmauch, Jarmo Gunn, and Maija Hollmén. These collaborations indicate a consistent interdisciplinary approach encompassing molecular biology, cardiovascular medicine, and biomedical engineering.

Their publications appear predominantly in sources focused on biological sciences and cardiovascular research, reflecting the overlapping themes central to their scientific inquiry:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Circulation
  • Atherosclerosis
  • Blood Advances

Core areas of study in Garcia-Cardeña's work include:

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Immunology
  • Biomedical Engineering
  • Public Health, Environmental and Occupational Health

Their main research topics cover:

  • Cardiac Fibrosis and Remodeling
  • Kruppel-like factors research
  • Angiogenesis and VEGF in Cancer
  • Single-cell and spatial transcriptomics
  • Atherosclerosis and Cardiovascular Diseases
  • 3D Printing in Biomedical Research
  • Congenital heart defects research

Best Publications

  • Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

    Michael A. Gimbrone;Guillermo García-Cardeña

  • Biological Action of Leptin as an Angiogenic Factor

    M. Rocı́o Sierra-Honigmann;Anjali K. Nath;Chiaki Murakami;Guillermo Garcı́a-Cardeña

  • Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

    Andreas Papapetropoulos;Guillermo García-Cardeña;Joseph A. Madri;William C. Sessa

  • Dynamic activation of endothelial nitric oxide synthase by Hsp90

    Guillermo García-Cardeña;Guillermo García-Cardeña;Roger Fan;Vijay Shah;Raffaella Sorrentino

  • Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesisa

    Michael A. Gimbrone;James N. Topper;Tobi Nagel;Keith R. Anderson

  • Recent insights into the cellular biology of atherosclerosis

    Ira Tabas;Guillermo García-Cardeña;Guillermo García-Cardeña;Gary K. Owens

  • Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

    Guillermo Garcı́a-Cardeña;Pavel Martasek;Bettie Sue Siler Masters;Phillip M. Skidd

  • KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.

    Sucharita SenBanerjee;Zhiyong Lin;G. Brandon Atkins;Daniel M. Greif

  • TARGETING OF NITRIC OXIDE SYNTHASE TO ENDOTHELIAL CELL CAVEOLAE VIA PALMITOYLATION : IMPLICATIONS FOR NITRIC OXIDE SIGNALING

    Guillermo Garcia-Cardena;Phil Oh;Jianwei Liu;Jan E. Schnitzer

  • Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature

    Guohao Dai;Mohammad R. Kaazempur-Mofrad;Sripriya Natarajan;Yuzhi Zhang

  • Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

    Kush M. Parmar;H. Benjamin Larman;Guohao Dai;Yuzhi Zhang

  • Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1

    Guillermo García-Cardeña;Roger Fan;David F. Stern;Jianwei Liu

  • 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization.

    Teresa Caulin-Glaser;G. García-Cardeña;Phillip Sarrel;William C. Sessa

  • Biomechanical activation of vascular endothelium as a determinant of its functional phenotype

    Guillermo García-Cardeña;Jason Comander;Keith R. Anderson;Brett R. Blackman

  • Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

    Andreas Papapetropoulos;Guillermo García-Cardeña;Thomas J. Dengler;Peter C. Maisonpierre

  • Biomechanical forces promote embryonic haematopoiesis

    Luigi Adamo;Olaia Naveiras;Olaia Naveiras;Pamela L. Wenzel;Pamela L. Wenzel;Shannon McKinney-Freeman;Shannon McKinney-Freeman

  • Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall

    Ravi M. Rao;Lin Yang;Guillermo Garcia-Cardena;Francis W. Luscinskas

  • Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis

    Michael A. Gimbrone;Guillermo García-Cardeña

  • Expression of EphrinB2 Identifies a Stable Genetic Difference Between Arterial and Venous Vascular Smooth Muscle as Well as Endothelial Cells, and Marks Subsets of Microvessels at Sites of Adult Neovascularization

    Donghun Shin;Guillermo Garcia-Cardena;Guillermo Garcia-Cardena;Shin-Ichiro Hayashi;Sebastian Gerety

  • Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

    Alan Daugherty;Alan R. Tall;Mat J.A.P. Daemen;Erling Falk

Frequent Co-Authors

Michael A. Gimbrone
Michael A. Gimbrone Brigham and Women's Hospital
William C. Sessa
William C. Sessa Pfizer (United States)
Jeffrey T. Borenstein
Jeffrey T. Borenstein Draper Laboratory
Andreas Papapetropoulos
Andreas Papapetropoulos National and Kapodistrian University of Athens
Frederick J. Schoen
Frederick J. Schoen Brigham and Women's Hospital
Francis W. Luscinskas
Francis W. Luscinskas Brigham and Women's Hospital
George Q. Daley
George Q. Daley Boston Children's Hospital
Roberto J. Groszmann
Roberto J. Groszmann Yale University
Stefan G. Tullius
Stefan G. Tullius Brigham and Women's Hospital

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