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Arthur L. Horwich

Arthur L. Horwich

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
35110
World Ranking
3802
National Ranking
1884

Research.com Recognitions

  • 2020 - Breakthrough Prize in Life Sciences for discovering functions of molecular chaperones in mediating protein folding and preventing protein aggregation.
  • 2019 - Dr. Paul Janssen Award for Biomedical Research, Johnson & Johnson for their revolutionary insights into chaperone-mediated protein folding.
  • 2019 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 2017 - E.B. Wilson Medal, American Society for Cell Biology
  • 2016 - Albany Medical Center Prize in Medicine and Biomedical Research
  • 2011 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2008 - Member of the National Academy of Medicine (NAM)
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Canada Gairdner International Award
  • 2003 - Member of the National Academy of Sciences

Overview

Arthur L. Horwich is affiliated with Yale University in the United States and specializes in the fields of biochemistry, genetics, and molecular biology. Their research incorporates several subfields including molecular biology, immunology, neurology, materials chemistry, and spectroscopy.

Their work frequently addresses topics such as heat shock proteins research, protein structure and dynamics, toxin mechanisms and immunotoxins, amyotrophic lateral sclerosis research, enzyme structure and function, advanced NMR techniques and applications, and electron spin resonance studies.

Among their recent publications are the following papers:

  • "Chaperonin-assisted protein folding: a chronologue" (2020) published in Quarterly Reviews of Biophysics
  • "Neuronal overexpression of potassium channel subunit Kcnn1 prolongs survival of SOD1-linked ALS and A53T alpha-synuclein mouse models" (2024) published in bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors in their research include Wayne A. Fenton, Eric B. Bertelsen, Jocelyne Fiaux, Kurt Wüthrich, and Mária Nagy.

Their work has been published mainly in outlets such as Quarterly Reviews of Biophysics and bioRxiv (Cold Spring Harbor Laboratory).

Awards and recognitions received by Arthur L. Horwich include the Breakthrough Prize in Life Sciences in 2020 for discovering functions of molecular chaperones in mediating protein folding and preventing protein aggregation. Additional distinctions include the Paul Ehrlich and Ludwig Darmstaedter Prize (2019), Dr. Paul Janssen Award for Biomedical Research from Johnson & Johnson (2019) for insights into chaperone-mediated protein folding, the E.B. Wilson Medal from the American Society for Cell Biology (2017), Albany Medical Center Prize in Medicine and Biomedical Research (2016), Albert Lasker Award for Basic Medical Research (2011), membership in the National Academy of Medicine (2008), fellowship in the American Association for the Advancement of Science (2006), the Canada Gairdner International Award (2004), and membership in the National Academy of Sciences (2003).

Best Publications

  • The Hsp70 and Hsp60 chaperone machines.

    Bernd Bukau;Arthur L Horwich

  • Molecular Chaperones and Protein Quality Control

    Bernd Bukau;Jonathan Weissman;Arthur Horwich;Arthur Horwich

  • The crystal structure of the asymmetric GroEL–GroES–(ADP) 7 chaperonin complex

    Zhaohui Xu;Arthur L. Horwich;Paul B. Sigler

  • The crystal structure of the bacterial chaperonin GroEL at 2.8 A.

    Kerstin Braig;Zbyszek Otwinowski;Zbyszek Otwinowski;Rashmi Hegde;Rashmi Hegde;David C. Boisvert

  • Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria.

    Ming Yuan Cheng;Franz-Ulrich Hartl;Jörg Martin;Robert A. Pollock

  • Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

    J Martin;T Langer;R Boteva;A Schramel

  • Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis.

    Joachim Ostermann;Arthur Horwich;Walter Neupert;Franz-Ulrich Hartl

  • Residues in chaperonin GroEL required for polypeptide binding and release

    Fenton Wa;Kashi Y;Furtak K;Horwich Al

  • STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING

    Paul B. Sigler;Zhaohui Xu;Hays S. Rye;Steven G. Burston

  • Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell

    Elizabeth A. Craig;Jonathan S. Weissman;Arthur L. Horwich

  • TCP1 complex is a molecular chaperone in tubulin biogenesis.

    Michael B. Yaffe;George W. Farr;David Miklos;Arthur L. Horwich

  • Two Families of Chaperonin: Physiology and Mechanism

    Arthur L. Horwich;Wayne A. Fenton;Eli Chapman;George W. Farr

  • Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

    Eilika U. Weber-Ban;Brian G. Reid;Andrew D. Miranker;Arthur L. Horwich

  • NMR analysis of a 900K GroEL–GroES complex

    Jocelyne Fiaux;Eric B. Bertelsen;Arthur L. Horwich;Kurt Wüthrich

  • Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL

    Hays S. Rye;Steven G. Burston;Wayne A. Fenton;Joseph M. Beechem

  • GroEL-mediated protein folding.

    Wayne A. Fenton;Arthur L. Horwich

  • Folding in vivo of bacterial cytoplasmic proteins: Role of GroEL

    Arthur L. Horwich;K.Brooks Low;Wayne A. Fenton;Irvin N. Hirshfield

  • Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification.

    J Summers;P M Smith;A L Horwich

  • A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1

    J D Trent;E Nimmesgern;J S Wall;F U Hartl

  • Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction

    Jonathan S Weissman;Jonathan S Weissman;Hays S Rye;Hays S Rye;Wayne A Fenton;Joseph M Beechem

Frequent Co-Authors

Wayne A. Fenton
Wayne A. Fenton Yale University
Helen R. Saibil
Helen R. Saibil Birkbeck, University of London
Leon E. Rosenberg
Leon E. Rosenberg Yale University
Walter Neupert
Walter Neupert Max Planck Institute of Biochemistry
Kurt Wüthrich
Kurt Wüthrich ETH Zurich
Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Paul B. Sigler
Paul B. Sigler Yale University
Jan P. Kraus
Jan P. Kraus University of Colorado Denver
Lila M. Gierasch
Lila M. Gierasch University of Massachusetts Amherst

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