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Wayne A. Fenton

Wayne A. Fenton

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
12189
World Ranking
15514
National Ranking
6475

Overview

Wayne A. Fenton is affiliated with Yale University in the United States and conducts research primarily within the fields of Biochemistry, Genetics, and Molecular Biology. Their work encompasses subfields such as Molecular Biology, Immunology, and Neurology, reflecting a multifaceted approach to understanding biological systems.

The main topics covered in Wayne A. Fenton's research include Heat shock proteins research, Toxin Mechanisms and Immunotoxins, Protein Structure and Dynamics, and Amyotrophic Lateral Sclerosis Research. These interconnected areas suggest a focus on molecular mechanisms underpinning protein behavior and neurological conditions.

They have published peer-reviewed work in venues including Quarterly Reviews of Biophysics and bioRxiv (Cold Spring Harbor Laboratory). Notable recent papers include:

  • Chaperonin-assisted protein folding: a chronologue, 2020, Quarterly Reviews of Biophysics
  • Neuronal overexpression of potassium channel subunit Kcnn1 prolongs survival of SOD1-linked ALS and A53T alpha-synuclein mouse models, 2024, bioRxiv (Cold Spring Harbor Laboratory)

The scientist collaborates frequently with colleagues such as Arthur L. Horwich, Mária Nagy, and Justin Cotney, indicating a cooperative research network focused on their areas of expertise.

Best Publications

  • Residues in chaperonin GroEL required for polypeptide binding and release

    Fenton Wa;Kashi Y;Furtak K;Horwich Al

  • STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING

    Paul B. Sigler;Zhaohui Xu;Hays S. Rye;Steven G. Burston

  • Two Families of Chaperonin: Physiology and Mechanism

    Arthur L. Horwich;Wayne A. Fenton;Eli Chapman;George W. Farr

  • Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes

    Jonathan S. Weissman;Jonathan S. Weissman;Corinne M. Hohl;Corinne M. Hohl;Oleg Kovalenko;Yechezkel Kashi

  • Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL

    Hays S. Rye;Steven G. Burston;Wayne A. Fenton;Joseph M. Beechem

  • GroEL-mediated protein folding.

    Wayne A. Fenton;Arthur L. Horwich

  • Folding in vivo of bacterial cytoplasmic proteins: Role of GroEL

    Arthur L. Horwich;K.Brooks Low;Wayne A. Fenton;Irvin N. Hirshfield

  • Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction

    Jonathan S Weissman;Jonathan S Weissman;Hays S Rye;Hays S Rye;Wayne A Fenton;Joseph M Beechem

  • GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms

    Jonathan S. Weissman;Yechezkel Kashi;Wayne A. Fenton;Arthur L. Horwich

  • GroEL-GroES Cycling: ATP and Nonnative Polypeptide Direct Alternation of Folding-Active Rings

    Hays S. Rye;Hays S. Rye;Alan M. Roseman;Shaoxia Chen;Krystyna Furtak;Krystyna Furtak

  • Prenatal diagnosis and carrier detection of Duchenne muscular dystrophy with closely linked RFLPs.

    E Bakker;N Goor;K Wrogemann;L.M Kunkel

  • Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase.

    Arthur L. Horwich;Wayne A. Fenton;Kenneth R. Williams;Frantisek Kalousek

  • ATP-Bound States of GroEL Captured by Cryo-Electron Microscopy

    Neil A. Ranson;George W. Farr;George W. Farr;Alan M. Roseman;Brent Gowen

  • GroEL-GroES-mediated protein folding.

    Arthur L. Horwich;George W. Farr;Wayne A. Fenton

  • Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation.

    Jörg Hinnerwisch;Wayne A. Fenton;Wayne A. Fenton;Krystyna J. Furtak;George W. Farr

  • Clinical heterogeneity and prognosis in combined methylmalonic aciduria and homocystinuria (cblC)

    D. S. Rosenblatt;A. L. Aspler;M. I. Shevell;B. A. Pletcher

  • Targeting of pre-ornithine transcarbamylase to mitochondria: Definition of critical regions and residues in the leader peptide

    Arthur L. Horwich;Frantisek Kalousek;Wayne A. Fenton;Robert A. Pollock

  • Chaperonin-mediated protein folding : fate of substrate polypeptide

    Wayne A. Fenton;Arthur L. Horwich

  • GroEL/GroES-Mediated Folding of a Protein Too Large to Be Encapsulated

    Tapan K. Chaudhuri;Tapan K. Chaudhuri;George W. Farr;George W. Farr;Wayne A. Fenton;Sabine Rospert

  • Structure and allostery of the chaperonin GroEL.

    Helen R. Saibil;Wayne A. Fenton;Daniel K. Clare;Arthur L. Horwich

Frequent Co-Authors

Arthur L. Horwich
Arthur L. Horwich Yale University
Leon E. Rosenberg
Leon E. Rosenberg Yale University
Helen R. Saibil
Helen R. Saibil Birkbeck, University of London
Jan P. Kraus
Jan P. Kraus University of Colorado Denver
Fred D. Ledley
Fred D. Ledley Bentley University
Kurt Wüthrich
Kurt Wüthrich ETH Zurich
Rowena G. Matthews
Rowena G. Matthews University of Michigan–Ann Arbor
Scott T. Brady
Scott T. Brady University of Illinois at Chicago
Andreas G. Tzakis
Andreas G. Tzakis Cleveland Clinic

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