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Tania A. Baker

Tania A. Baker

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
23262
World Ranking
2879
National Ranking
1478

Overview

Tania A. Baker is affiliated with MIT in the United States and works primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their research spans various subfields including Molecular Biology, Genetics, Cell Biology, Ecology, and Materials Chemistry. The scientist's work covers key topics such as Bacterial Genetics and Biotechnology, RNA and protein synthesis mechanisms, Cellular transport and secretion, Bacteriophages and microbial interactions, Signaling Pathways in Disease, Protein Structure and Dynamics, and Enzyme Structure and Function.

Among recent publications, Tania A. Baker has contributed to several articles in notable venues. These include:

  • Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate (2020, eLife)
  • Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates (2020, eLife)
  • Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis (2021, Critical Reviews in Biochemistry and Molecular Biology)
  • Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding (2020, eLife)
  • The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation (2020, Cell Reports)

The scientist frequently publishes in several academic journals and repositories. The main venues of publication include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Cell Reports
  • Proceedings of the National Academy of Sciences
  • Journal of Biological Chemistry

Collaborations are a significant aspect of their research, with frequent co-authors comprising:

  • Robert T. Sauer
  • Tristan A. Bell
  • Alireza Ghanbarpour
  • Joseph H. Davis
  • Fei X

This profile reflects a research career focused on understanding molecular machines involved in protein degradation and regulation, as indicated by the emphasis on ClpXP and ClpAP proteolytic complexes. The diverse range of research topics and repeated contributions to highly regarded journals suggest an active engagement in advancing knowledge in molecular biology and related disciplines.

Best Publications

  • A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli.

    M Singer;T A Baker;G Schnitzler;S M Deischel

  • AAA+ proteases: ATP-fueled machines of protein destruction.

    Robert T. Sauer;Tania A. Baker

  • Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals.

    Julia M Flynn;Saskia B Neher;Yong In Kim;Robert T Sauer

  • ClpXP, an ATP-powered unfolding and protein-degradation machine

    Tania A. Baker;Robert T. Sauer

  • Sculpting the Proteome with AAA+ Proteases and Disassembly Machines

    Robert T. Sauer;Daniel N. Bolon;Briana M. Burton;Randall E. Burton

  • Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

    Andreas Martin;Tania A. Baker;Robert T. Sauer

  • Polymerases and the Replisome: Machines within Machines

    Tania A Baker;Stephen P Bell

  • A specificity-enhancing factor for the ClpXP degradation machine.

    Igor Levchenko;Meredith Seidel;Robert T. Sauer;Tania A. Baker

  • Dynamics of Substrate Denaturation and Translocation by the ClpXP Degradation Machine

    Yong-In Kim;Randall E. Burton;Briana M. Burton;Robert T. Sauer

  • Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis

    Julia M. Flynn;Igor Levchenko;Meredith Seidel;Sue H. Wickner

  • Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

    Yong-In Kim;Igor Levchenko;Igor Levchenko;Karolina Fraczkowska;Rachel V. Woodruff

  • Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine

    Jon A. Kenniston;Tania A. Baker;Julio M. Fernandez;Robert T. Sauer

  • Disassembly of the Mu transposase tetramer by the ClpX chaperone.

    Igor Levchenko;Li Luo;Tania A. Baker

  • Segregation of molecules at cell division reveals native protein localization

    Dirk Landgraf;Burak Okumus;Peter Chien;Peter Chien;Tania A Baker

  • Extensive unwinding of the plasmid template during staged enzymatic initiation of DNA replication from the origin of the Escherichia coli chromosome

    Tania A. Baker;Kazuhisa Sekimizu;Barbara E. Funnell;Arthur Kornberg

  • Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine

    Marie-Eve Aubin-Tam;Adrian O. Olivares;Robert T. Sauer;Tania A. Baker

  • Engineering controllable protein degradation.

    Kathleen E. McGinness;Tania A. Baker;Robert T. Sauer

  • ATP-dependent proteases of bacteria: recognition logic and operating principles.

    Tania A. Baker;Robert T. Sauer

  • In vitro assembly of a prepriming complex at the origin of the Escherichia coli chromosome.

    B.E. Funnell;T.A. Baker;A. Kornberg

  • ClpXP, an ATP-powered unfolding and protein-degradation machine

    Robert T. Sauer;Tania Baker

Frequent Co-Authors

Andreas Martin
Andreas Martin University of California, Berkeley
Stephen C. Harrison
Stephen C. Harrison Harvard University
Barry H. Paw
Barry H. Paw Brigham and Women's Hospital
Arthur Kornberg
Arthur Kornberg Stanford University
Kiyoshi Mizuuchi
Kiyoshi Mizuuchi National Institutes of Health
Thomas Braun
Thomas Braun Max Planck Society
Marcus Krüger
Marcus Krüger University of Cologne

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