World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
12474
World Ranking
13147
National Ranking
1026

Research.com Recognitions

  • 2004 - Member of the National Academy of Sciences
  • 2002 - Fellow of the American Academy of Arts and Sciences
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Sue Wickner is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. The primary area of their research is within Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology. Their work extensively covers Heat Shock Proteins research, a core topic in their publications.

The scientist has contributed to several peer-reviewed articles, including the following recent papers:

  • The Bacterial Hsp90 Chaperone: Cellular Functions and Mechanism of Action (2021), Annual Review of Microbiology
  • J-domain Proteins form Binary Complexes with Hsp90 and Ternary Complexes with Hsp90 and Hsp70 (2023), Journal of Molecular Biology
  • Hsp90, a team player in protein quality control and the stress response in bacteria (2024), Microbiology and Molecular Biology Reviews
  • Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity (2024), PLoS Genetics
  • Structure of phosphorylated-like RssB, the adaptor delivering σs to the ClpXP proteolytic machinery, reveals an interface switch for activation (2023), Journal of Biological Chemistry

Their research themes emphasize enzyme structure and function, protein structure and dynamics, and aspects of toxin mechanisms and immunotoxins. Several works integrate biophysical approaches such as thermodynamics and calorimetric analyses. The scientist's investigations also reach areas including plant biochemistry and biosynthesis as well as viral infectious diseases and gene expression in insects.

Frequent co-authors collaborating in this research include:

  • Joel R. Hoskins
  • Anushka Wickramaratne
  • Andrea N. Kravats
  • Lisa M. Jenkins
  • Shannon M. Doyle

The main publication venues that showcase the scientist's work are:

  • Journal of Biological Chemistry
  • Annual Review of Microbiology
  • Journal of Molecular Biology
  • Microbiology and Molecular Biology Reviews
  • PLoS Genetics

The scientist has been recognized by several awards, including election as a Member of the National Academy of Sciences in 2004. Earlier honors include Fellowship of the American Academy of Arts and Sciences in 2002 and Fellowship of the American Association for the Advancement of Science (AAAS) in 2001.

Best Publications

  • Posttranslational quality control: folding, refolding, and degrading proteins.

    Sue Wickner;Michael R. Maurizi;Susan Gottesman

  • Protein quality control: triage by chaperones and proteases.

    S Gottesman;S Wickner;M R Maurizi

  • A molecular chaperone, ClpA, functions like DnaK and DnaJ

    Sue Wickner;Susan Gottesman;Dorota Skowyra;Joel Hoskins

  • The RssB response regulator directly targets ςS for degradation by ClpXP

    YanNing Zhou;Susan Gottesman;Joel R. Hoskins;Michael R. Maurizi

  • Hsp104 and ClpB: protein disaggregating machines.

    Shannon M. Doyle;Sue Wickner

  • Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis

    Julia M. Flynn;Igor Levchenko;Meredith Seidel;Sue H. Wickner

  • Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling.

    Olivier Genest;Sue Wickner;Shannon M. Doyle

  • Protein rescue from aggregates by powerful molecular chaperone machines

    Shannon M. Doyle;Olivier Genest;Sue Wickner

  • Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP.

    Satyendra K. Singh;Regis Grimaud;Joel R. Hoskins;Sue Wickner

  • Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA

    Sue Wickner;Joel Hoskins;Keith McKenney

  • Regulatory Subunits of Energy-Dependent Proteases

    Susan Gottesman;Michael R Maurizi;Sue Wickner

  • Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin

    Sue Wickner;Joel Hoskins;Keith McKenney

  • Interaction of Escherichia coli dnaB and dnaC(D) gene products in vitro.

    Sue Wickner;Jerard Hurwitz

  • Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

    Shannon M Doyle;James Shorter;Michal Zolkiewski;Joel R Hoskins

  • Conversion of ϕX174 Viral DNA to Double-Stranded Form by Purified Escherichia coli Proteins

    Sue Wickner;Jerard Hurwitz

  • Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP.

    Joel R. Hoskins;Satyendra K. Singh;Michael R. Maurizi;Sue Wickner

  • Modulating RssB activity: IraP, a novel regulator of sigma(S) stability in Escherichia coli.

    Alexandre Bougdour;Sue Wickner;Susan Gottesman

  • ClpXP protease degrades the cytoskeletal protein, FtsZ, and modulates FtsZ polymer dynamics

    Jodi L. Camberg;Joel R. Hoskins;Sue Wickner

  • The role of the ClpA chaperone in proteolysis by ClpAP

    Joel R. Hoskins;Marie Pak;Michael R. Maurizi;Sue Wickner

  • Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation

    Marika Miot;Michael Reidy;Shannon M. Doyle;Joel R. Hoskins

Frequent Co-Authors

Michael R. Maurizi
Michael R. Maurizi National Institutes of Health
Jerard Hurwitz
Jerard Hurwitz Memorial Sloan Kettering Cancer Center
Susan Gottesman
Susan Gottesman National Institutes of Health
David A. Agard
David A. Agard University of California, San Francisco
Alasdair C. Steven
Alasdair C. Steven National Institutes of Health
Arthur L. Horwich
Arthur L. Horwich Yale University
Reed B. Wickner
Reed B. Wickner National Institutes of Health
Lila M. Gierasch
Lila M. Gierasch University of Massachusetts Amherst
Kiyoshi Mizuuchi
Kiyoshi Mizuuchi National Institutes of Health

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