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Maciej Zylicz

Maciej Zylicz

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
11274
World Ranking
16081
National Ranking
6666

Research.com Recognitions

  • 2011 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Genetics/Molecular Biology and Cell Biology
  • 2007 - Polish Academy of Science
  • 2001 - Member of Academia Europaea
  • 1999 - Prize of the Foundation for Polish Science - Nagroda Fundacji na rzecz Nauki Polskiej for research on regulatory proteins constituting part of the system protecting cells against undesirable changes in their external environment
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Maciej Zylicz is affiliated with United Way in the United States and conducts research in the field of Biochemistry, Genetics, and Molecular Biology. Their work primarily focuses on molecular biology and cell biology, with notable engagement in immunology and, to a lesser extent, epidemiology and mechanical engineering.

The primary topics addressed in Zylicz's research include:

  • Endoplasmic Reticulum Stress and Disease
  • Heat shock proteins research
  • Ubiquitin and proteasome pathways
  • Toxin Mechanisms and Immunotoxins
  • Autophagy in Disease and Therapy
  • Advanced Thermodynamic Systems and Engines
  • Cancer-related Molecular Pathways

Zylicz has published research in several scientific venues, with repeated contributions to journals such as:

  • Cancers
  • Cell Reports
  • Cell Stress and Chaperones
  • bioRxiv (Cold Spring Harbor Laboratory)

Some recent papers authored or co-authored by Zylicz include:

  • "The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells" (2022, Cell Reports)
  • "J-domain proteins: From molecular mechanisms to diseases" (2024, Cell Stress and Chaperones)
  • "HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells" (2020, Cancers)
  • "Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and Chemoresistance" (2021, Cancers)
  • "The response network of HSP70 defines vulnerabilities in cancer cells with the inhibited proteasome" (2021, bioRxiv (Cold Spring Harbor Laboratory))

Frequently collaborating co-authors include:

  • Magdalena Oroń
  • Marcin Grochowski
  • Akanksha Jaiswar
  • Justyna Legierska
  • Kamil Jastrzębski

Throughout their career, Zylicz has received recognition from various scientific institutions. These awards include membership in the European Molecular Biology Organization (EMBO), election to the Polish Academy of Science in 2007, and membership in Academia Europaea since 2001. They were awarded the Prize of the Foundation for Polish Science in 1999 for research on regulatory proteins involved in cellular protection mechanisms. Additionally, in 2011, Zylicz was inducted into the German National Academy of Sciences Leopoldina for contributions in Genetics, Molecular Biology, and Cell Biology.

Best Publications

  • Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

    Krzysztof Liberek;Jaroslaw Marszalek;Debbie Ang;Costa Georgopoulos

  • High guanine and cytosine content increases mRNA levels in mammalian cells.

    Grzegorz Kudla;Leszek Lipinski;Leszek Lipinski;Fanny Caffin;Aleksandra Helwak;Aleksandra Helwak

  • The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase.

    B Lipinska;M Zylicz;C Georgopoulos

  • The dnaK protein modulates the heat-shock response of Escherichia coli

    Kit Tilly;Niki McKittrick;Maciej Zylicz;Costa Georgopoulos

  • Biological role and regulation of the universally conserved heat shock proteins.

    Debbie Ang;Krzysztof Liberek;Krzysztof Liberek;Dorota Skowyra;Maciej Zylicz

  • Initiation of lambda DNA replication with purified host- and bacteriophage-encoded proteins: the role of the dnaK, dnaJ and grpE heat shock proteins.

    M. Zylicz;D. Ang;K. Liberek;C. Georgopoulos

  • The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication.

    Daniel Wall;Maciej Zylicz;Costa Georgopoulos

  • Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli.

    Diana Wojtkowiak;Costa Georgopoulos;Maciej Zylicz

  • The dnaK protein of Escherichia coli possesses an ATPase and autophosphorylating activity and is essential in an in vitro DNA replication system.

    Maciej Zylicz;Jonathan H. Lebowitz;Roger McMacken;Costa Georgopoulos

  • The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein.

    Krzysztof Liberek;Dorota Skowyra;Maciej Zylicz;Claudia Johnson

  • The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.

    A. Wawrzynow;D. Wojtkowiak;J. Marszalek;B. Banecki

  • Hsp70 interactions with the p53 tumour suppressor protein

    Maciej Zylicz;Frank W King;Alicja Wawrzynow

  • Role of the Escherichia coli DnaK and DnaJ heat shock proteins in the initiation of bacteriophage lambda DNA replication

    Krzysztof Liberek;Costa Georgopoulos;Maciej Zylicz

  • Purification and properties of the dnaJ replication protein of Escherichia coli.

    M Zylicz;T Yamamoto;N McKittrick;S Sell

  • The DnaK chaperone modulates the heat shock response of Escherichia coli by binding to the sigma 32 transcription factor

    Krzysztof Liberek;Timothy P. Galitski;Maciej Zylicz;Costa Georgopoulos

  • Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

    Frank W. King;Alicja Wawrzynow;Jörg Höhfeld;Maciej Zylicz

  • The grpE protein of Escherichia coli. Purification and properties.

    M Zylicz;D Ang;C Georgopoulos

  • The nucleotide sequence of the Escherichia coli K12 dnaJ+ gene. A gene that encodes a heat shock protein.

    J. C A Bardwell;K. Tilly;E. Craig;J. King

  • Structure-Function Analysis of the Zinc Finger Region of the DnaJ Molecular Chaperone

    Bogdan Banecki;Krzysztof Liberek;Daniel Wall;Alicja Wawrzynów

  • Purification and properties of the Escherichia coli dnaK replication protein.

    M Zylicz;C Georgopoulos

Frequent Co-Authors

Costa Georgopoulos
Costa Georgopoulos University of Utah
Giovanni Blandino
Giovanni Blandino McMaster University
Daniel Wall
Daniel Wall University of Wyoming
Elizabeth A. Craig
Elizabeth A. Craig University of Wisconsin–Madison
Jason E. Gestwicki
Jason E. Gestwicki University of California, San Francisco
Kazuhiro Nagata
Kazuhiro Nagata Kyoto Sangyo University
Barbara J. Graves
Barbara J. Graves University of Utah
Harm H. Kampinga
Harm H. Kampinga University Medical Center Groningen
Maciej Wiznerowicz
Maciej Wiznerowicz Poznan University of Medical Sciences
James C. A. Bardwell
James C. A. Bardwell University of Michigan–Ann Arbor

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