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Matthias P. Mayer

Matthias P. Mayer

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
23208
World Ranking
5002
National Ranking
367

Overview

Matthias P. Mayer is affiliated with Heidelberg University in Germany and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Cell Biology, and Immunology. Their work spans several subfields including Physical and Theoretical Chemistry and Mechanical Engineering.

The primary topics of their research encompass:

  • Heat shock proteins research
  • Thermodynamics and calorimetric analyses
  • Endoplasmic Reticulum Stress and Disease
  • Protein Structure and Dynamics
  • Ubiquitin and proteasome pathways
  • Computational Drug Discovery Methods
  • Toxin Mechanisms and Immunotoxins

Matthias P. Mayer has published papers in a variety of scientific journals, frequently contributing to bioRxiv (Cold Spring Harbor Laboratory) where they have six publications. Other key venues include the Journal of Biological Chemistry with four publications, Cell Stress and Chaperones with three, and Cell Reports and Procedia CIRP with two each.

Recent notable papers include:

  • "Molecular mechanisms of heat shock factor 1 regulation," 2021, published in Trends in Biochemical Sciences
  • "Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70-mediated trimer unzipping and dissociation from DNA," 2020, published in The EMBO Journal
  • "The Hsp70-Chaperone Machines in Bacteria," 2021, published in Frontiers in Molecular Biosciences
  • "Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones," 2020, published in Journal of Biological Chemistry
  • "Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25," 2020, published in Cell Reports

Their collaborations involve frequent co-authors including Lukas Rohland, Szymon W. Kmiecik, Gregory L. Blatch, Pierre Goloubinoff, and Jason E. Gestwicki. These collaborations have contributed to an interdisciplinary approach combining biochemistry, molecular biology, and cellular stress responses.

Best Publications

  • Hsp70 chaperones: cellular functions and molecular mechanism.

    Matthias P. Mayer;Bernd Bukau

  • The Hsp70 chaperone network

    Rina Rosenzweig;Nadinath B. Nillegoda;Matthias P. Mayer;Bernd Bukau;Bernd Bukau

  • Mechanism of regulation of Hsp70 chaperones by DnaJ cochaperones

    Thomas Laufen;Matthias P. Mayer;Christian Beisel;Dagmar Klostermeier

  • Hsp70 chaperone dynamics and molecular mechanism.

    Matthias P. Mayer

  • Gymnastics of Molecular Chaperones

    Matthias P. Mayer

  • Multistep mechanism of substrate binding determines chaperone activity of Hsp70

    Matthias P. Mayer;Hartwig Schröder;Stefan Rüdiger;Klaus Paal

  • Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins.

    Dominique Missiakas;Matthias P. Mayer;Marc Lemaire;Costa Georgopoulos

  • Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

    Roman Kityk;Jürgen Kopp;Irmgard Sinning;Matthias P. Mayer

  • Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

    Nadinath B. Nillegoda;Janine Kirstein;Anna Szlachcic;Mykhaylo Berynskyy

  • Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

    Xuechao Gao;Xuechao Gao;Marta Carroni;Carmen Nussbaum-Krammer;Carmen Nussbaum-Krammer;Axel Mogk;Axel Mogk

  • A new set of useful cloning and expression vectors derived from pBlueScript.

    Matthias P. Mayer

  • Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor

    Holger Raviol;Heather Sadlish;Fernanda Rodriguez;Matthias P Mayer

  • Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies.

    M. P. Mayer

  • Allosteric Regulation of Hsp70 Chaperones Involves a Conserved Interdomain Linker

    Markus Vogel;Matthias P. Mayer;Bernd Bukau

  • Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.

    Dirk Brehmer;Stefan Rüdiger;Claudia S. Gässler;Dagmar Klostermeier;Dagmar Klostermeier

  • Domino iron catalysis: direct aryl-alkyl cross-coupling.

    Waldemar Maximilian Czaplik;Matthias Mayer;Axel Jacobi von Wangelin

  • Mechanics of Hsp70 chaperones enables differential interaction with client proteins

    Rainer Schlecht;Annette H Erbse;Annette H Erbse;Bernd Bukau;Matthias P Mayer

  • Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones.

    Roman Kityk;Jürgen Kopp;Matthias P. Mayer

  • Allosteric regulation of Hsp70 chaperones by a proline switch.

    Markus Vogel;Bernd Bukau;Matthias P. Mayer

  • Functional analysis of hsp70 inhibitors.

    Rainer Schlecht;Sebastian R. Scholz;Heike Dahmen;Ansgar Wegener

Frequent Co-Authors

Bernd Bukau
Bernd Bukau Heidelberg University
Axel Jacobi von Wangelin
Axel Jacobi von Wangelin Universität Hamburg
Axel Mogk
Axel Mogk Heidelberg University
Stefan G.D. Rüdiger
Stefan G.D. Rüdiger Utrecht University
Rebecca C. Wade
Rebecca C. Wade Heidelberg Institute for Theoretical Studies
Irmgard Sinning
Irmgard Sinning Heidelberg University
Sabine Rospert
Sabine Rospert University of Freiburg
Chrisostomos Prodromou
Chrisostomos Prodromou University of Sussex
Walter Nickel
Walter Nickel Heidelberg University
Masaru Tomita
Masaru Tomita Keio University

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