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Stefan G.D. Rüdiger

Stefan G.D. Rüdiger

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
10408
World Ranking
18614
National Ranking
442

Overview

Stefan G.D. Rüdiger is affiliated with Utrecht University in the Netherlands and has an extensive research portfolio primarily situated within Biochemistry, Genetics, and Molecular Biology. Their work comprises 38 publications in this broad field, with a particular focus on Molecular Biology, which accounts for 29 of these studies. Additional subfields include Physiology, Materials Chemistry, Cell Biology, and Spectroscopy.

The scientist's research spans several key topics, with notable attention to Heat Shock Proteins research, Alzheimer's disease research and treatments, and Enzyme Structure and Function. Other notable topics include Endoplasmic Reticulum Stress and Disease, Protein Structure and Dynamics, Ubiquitin and proteasome pathways, and Advanced Proteomics Techniques and Applications.

Stefan G.D. Rüdiger has contributed to diverse highly regarded journals and publication venues. Among the most frequent are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Molecular Biosciences
  • Nature Communications
  • Science Advances
  • Trends in Neurosciences

Selected recent papers include:

  • The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation, 2020, Nature Communications
  • The mechanism of Hsp90-induced oligomerizaton of Tau, 2020, Science Advances
  • Molecular Strategies to Target Protein Aggregation in Huntington's Disease, 2021, Frontiers in Molecular Biosciences
  • Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau, 2020, Nature Communications
  • How do protein aggregates escape quality control in neurodegeneration?, 2022, Trends in Neurosciences

The research collaborations include frequent co-authorship with Margreet B. Koopman, Assaf Friedler, Françoise A. Dekker, Guy Mayer, and Júlia Aragonès Pedrola.

Best Publications

  • Substrate specificity of the DnaK chaperone determined by screening cellulose‐bound peptide libraries

    Stefan Rüdiger;Lothar Germeroth;Jens Schneider‐Mergener;Bernd Bukau

  • Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB

    Axel Mogk;Toshifumi Tomoyasu;Pierre Goloubinoff;Stefan Rüdiger

  • Interaction of Hsp70 chaperones with substrates

    Stefan Rüdiger;Alexander Buchberger;Bernd Bukau;Bernd Bukau

  • Multistep mechanism of substrate binding determines chaperone activity of Hsp70

    Matthias P. Mayer;Hartwig Schröder;Stefan Rüdiger;Klaus Paal

  • Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

    G. Elif Karagöz;G. Elif Karagöz;Afonso M.S. Duarte;Afonso M.S. Duarte;Elias Akoury;Hans Ippel;Hans Ippel

  • Its substrate specificity characterizes the DnaJ co‐chaperone as a scanning factor for the DnaK chaperone

    Stefan Rüdiger;Jens Schneider‐Mergener;Bernd Bukau

  • A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32.

    J. Gamer;G. Multhaup;T. Tomoyasu;J. S. McCarty

  • A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants

    Assaf Friedler;Lars O. Hansson;Dmitry B. Veprintsev;Stefan M. V. Freund

  • Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.

    Dirk Brehmer;Stefan Rüdiger;Claudia S. Gässler;Dagmar Klostermeier;Dagmar Klostermeier

  • Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein.

    Jan Brix;Stefan Rüdiger;Bernd Bukau;Jens Schneider-Mergener

  • Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.

    Daniele V. F. Tauriello;Ingrid Jordens;Katharina Kirchner;Jerry W. Slootstra

  • Hsp90 interaction with clients

    G. Elif Karagöz;Stefan G.D. Rüdiger

  • The Hsp70-Hsp90 Chaperone Cascade in Protein Folding.

    Tania Morán Luengo;Matthias P. Mayer;Stefan G.D. Rüdiger

  • Binding specificity of Escherichia coli trigger factor.

    Holger Patzelt;Stefan Rüdiger;Dirk Brehmer;Günter Kramer

  • Regulation of α-synuclein by chaperones in mammalian cells.

    Björn M. Burmann;Björn M. Burmann;Juan A. Gerez;Irena Matečko-burmann;Irena Matečko-burmann;Silvia Campioni;Silvia Campioni

  • Studying protein-protein interactions using peptide arrays.

    Chen Katz;Liron Levy-Beladev;Shahar Rotem-Bamberger;Tiago Rito

  • Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

    David P Minde;Zeinab Anvarian;Stefan Gd Rüdiger;Madelon M Maurice

  • Substrate Specificity of the SecB Chaperone

    Nicola T.M. Knoblauch;Stefan Rüdiger;Hans-Joachim Schönfeld;Arnold J.M. Driessen

  • Molecular Basis for Regulation of the Heat Shock Transcription Factor σ32 by the DnaK and DnaJ Chaperones

    Fernanda Rodriguez;Florence Arsène-Ploetze;Wolfgang Rist;Stefan Rüdiger

  • Molecular basis for interactions of the DnaK chaperone with substrates.

    Matthias P. Mayer;Stefan Rüdiger;Bernd Bukau

Frequent Co-Authors

Bernd Bukau
Bernd Bukau Heidelberg University
Luca Ferrari
Luca Ferrari National Autonomous University of Mexico
Dmitry B. Veprintsev
Dmitry B. Veprintsev University of Nottingham
Matthias P. Mayer
Matthias P. Mayer Heidelberg University
Jens Schneider-Mergener
Jens Schneider-Mergener Humboldt-Universität zu Berlin
Rolf Boelens
Rolf Boelens Utrecht University
Casper C. Hoogenraad
Casper C. Hoogenraad Utrecht University
Stefan M.V. Freund
Stefan M.V. Freund MRC Laboratory of Molecular Biology
Michel O. Steinmetz
Michel O. Steinmetz Paul Scherrer Institute
Alan R. Fersht
Alan R. Fersht University of Cambridge

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