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Biology and Biochemistry

D-Index
45
Citations
8669
World Ranking
19087
National Ranking
565

Research.com Recognitions

  • Fellow of the Royal Society of South Africa
  • Fellow of the Royal Society of South Africa
  • Fellow of the Royal Society of South Africa

Overview

Gregory L. Blatch is affiliated with the University of Notre Dame Australia. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a particular concentration on molecular biology within this field. They have contributed extensively to studies related to heat shock proteins, computational drug discovery methods, and malaria research and control.

The main topics covered in their research include:

  • Heat shock proteins research
  • Computational Drug Discovery Methods
  • Malaria Research and Control
  • Protein Structure and Dynamics
  • Viral Infectious Diseases and Gene Expression in Insects
  • Toxin Mechanisms and Immunotoxins
  • Vector-borne infectious diseases

Blatch's publication record includes a number of recent papers with a focus on molecular chaperones and related proteins. Notable works include:

  • "Hsp90 and Associated Co-Chaperones of the Malaria Parasite" (2022) published in Biomolecules
  • "Exported plasmodial J domain protein, PFE0055c, and PfHsp70-x form a specific co-chaperone-chaperone partnership" (2020) published in Cell Stress and Chaperones
  • "STIP1/HOP Regulates the Actin Cytoskeleton through Interactions with Actin and Changes in Actin-Binding Proteins Cofilin and Profilin" (2020) published in International Journal of Molecular Sciences
  • "Hsp70/Hsp90 Organising Protein (Hop): Coordinating Much More than Chaperones" (2022) published in Sub-cellular biochemistry/Subcellular biochemistry
  • "J-domain proteins: From molecular mechanisms to diseases" (2024) published in Cell Stress and Chaperones

The preferred venues for publication include:

  • Cell Stress and Chaperones
  • International Journal of Molecular Sciences
  • Frontiers in Molecular Biosciences
  • Methods in molecular biology
  • Harvard Dataverse

Blatch frequently collaborates with other researchers, with several recurrent co-authors including:

  • Harpreet Singh
  • Adrienne L. Edkins
  • Tanima Dutta
  • Jason E. Gestwicki
  • Shaikha Y. Almaazmi

In addition to journal publications, Blatch has contributed to books, including a publication with Springer Nature titled "Heat Shock Proteins of Malaria" in 2021.

Their work spans both foundational and applied research, incorporating computational approaches and experimental studies relevant to protein dynamics and infectious disease mechanisms.

Blatch has been recognized as a Fellow of the Royal Society of South Africa, acknowledging their contributions to their scientific field.

Best Publications

  • The tetratricopeptide repeat: a structural motif mediating protein-protein interactions.

    Gregory L. Blatch;Michael Lässle

  • The African coelacanth genome provides insights into tetrapod evolution

    Chris T. Amemiya;Chris T. Amemiya;Jessica Alfoldi;Alison P. Lee;Shaohua Fan

  • Not all J domains are created equal: Implications for the specificity of Hsp40–Hsp70 interactions

    Fritha Hennessy;Williams S Nicoll;Richard Zimmermann;Michael E Cheetham

  • Hop: more than an Hsp70/Hsp90 adaptor protein

    O Odunuga;Victoria M Longshaw;Gregory L Blatch

  • The complex immunological and inflammatory network of adipose tissue in obesity.

    Vasso Apostolopoulos;Maximilian P. J. de Courten;Lily Stojanovska;Gregory L. Blatch

  • Stress-inducible, murine protein mSTI1: Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases

    Michael Lässle;Gregory L. Blatch;Vikas Kundra;Toshiro Takatori

  • The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

    David A. Parfitt;Gregory J. Michael;Esmeralda G.M. Vermeulen;Natalia V. Prodromou

  • Cancer stem cells in breast cancer and metastasis

    Jessica C. Lawson;Gregory L. Blatch;Adrienne L. Edkins

  • Plasmodium falciparum‐encoded exported hsp70/hsp40 chaperone/co‐chaperone complexes within the host erythrocyte

    Simone Kulzer;Sarah Charnaud;Tal Dagan;Jan Riedel

  • Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte.

    Simone Külzer;Melanie Rug;Klaus Brinkmann;Ping Cannon

  • The Hsp40 proteins of Plasmodium falciparum and other apicomplexa: regulating chaperone power in the parasite and the host.

    Melissa Botha;Eve-Rachele Pesce;Gregory L Blatch

  • The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum.

    Addmore Shonhai;Aileen Boshoff;Gregory L. Blatch

  • Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.

    Victoria M. Longshaw;J. Paul Chapple;Maria S. Balda;Michael E. Cheetham

  • Human DNAJ in cancer and stem cells

    Jason N. Sterrenberg;Gregory L. Blatch;Adrienne L. Edkins

  • Intracellular Protozoan Parasites of Humans: The Role of Molecular Chaperones in Development and Pathogenesis

    Addmore Shonhai;Alexander G. Maier;Jude M. Przyborski;Gregory L. Blatch

  • Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction: Molecular characterization of the critical contacts for successful binding and specificity

    Odutayo O. Odunuga;Judith A. Hornby;Christiane Bies;Richard Zimmermann

  • Heterologous expression of plasmodial proteins for structural studies and functional annotation

    Lyn-Marie Birkholtz;Gregory Blatch;Theresa L. Coetzer;Heinrich C. Hoppe;Heinrich C. Hoppe

  • Overproduction, purification, and characterization of the Plasmodium falciparum heat shock protein 70.

    Tonderayi S. Matambo;Odutayo O. Odunuga;Aileen Boshoff;Gregory L. Blatch

  • A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes.

    Johanna Dudek;Jörg Volkmer;Christiane Bies;Silvia Guth

  • Analysis of the levels of conservation of the J domain among the various types of DnaJ-like proteins.

    Fritha Hennessy;Michael E. Cheetham;Heini W. Dirr;Gregory L. Blatch

Frequent Co-Authors

Michael E. Cheetham
Michael E. Cheetham University College London
Richard Zimmermann
Richard Zimmermann Saarland University
Chris T. Amemiya
Chris T. Amemiya University of California, Merced
David R. Woods
David R. Woods University of Cape Town
Péter Csermely
Péter Csermely Semmelweis University
Bruce R. Zetter
Bruce R. Zetter Boston Children's Hospital
Vasso Apostolopoulos
Vasso Apostolopoulos RMIT University
Kerstin Lindblad-Toh
Kerstin Lindblad-Toh Uppsala University
Paul R. Gilson
Paul R. Gilson Burnet Institute
Fredrik Höök
Fredrik Höök Chalmers University of Technology

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