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Biology and Biochemistry

D-Index
78
Citations
37819
World Ranking
4436
National Ranking
334

Overview

Michael E. Cheetham is affiliated with University College London in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on several subfields including Molecular Biology, Cellular and Molecular Neuroscience, Ophthalmology, Genetics, and Neurology.

Their work encompasses a range of topics related to retinal biology and genetic disorders. Key areas of study include:

  • Retinal Development and Disorders
  • Retinal Diseases and Treatments
  • Photoreceptor and optogenetics research
  • CRISPR and Genetic Engineering
  • Mitochondrial Function and Pathology
  • RNA regulation and disease
  • Genetic and Kidney Cyst Diseases

Michael E. Cheetham has published research extensively, with recent papers including:

  • "Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids" (2020) in Stem Cell Reports
  • "Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial" (2022) in Nature Medicine
  • "Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa" (2020) in The American Journal of Human Genetics
  • "A look into retinal organoids: methods, analytical techniques, and applications" (2021) in Cellular and Molecular Life Sciences
  • "PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation" (2020) in Proceedings of the National Academy of Sciences

Their frequent co-authors include Rosellina Guarascio, Alison J. Hardcastle, Katarina Jovanović, Andrew R. Webster, and Kalliopi Ziaka.

Michael E. Cheetham's research findings are often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Human Molecular Genetics
  • Molecular Therapy - Nucleic Acids
  • The American Journal of Human Genetics
  • Acta Neuropathologica Communications

This scientist's multidisciplinary work intersects clinical and molecular approaches to understanding and treating retinal disorders, placing emphasis on experimental models like retinal organoids and genetic therapies. Their research contributes to ongoing efforts in exploring photoreceptor biology, genetic engineering techniques including CRISPR, and the molecular dynamics underpinning neurodegenerative and ophthalmic diseases.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the nomenclature of the human heat shock proteins

    Harm H. Kampinga;Jurre Hageman;Michel J. Vos;Hiroshi Kubota;Hiroshi Kubota

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function

    Michael E. Cheetham;Avrom J. Caplan

  • Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.

    Louise A Metherell;J Paul Chapple;Sadani Cooray;Alessia David

  • Targeting amyloid-β in glaucoma treatment

    Li Guo;Thomas E. Salt;Vy Luong;Nicholas Wood

  • Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy

    Hugo F. Mendes;Jacqueline van der Spuy;J. Paul Chapple;Michael E. Cheetham

  • In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance

    Irina Guzhova;Ksenia Kislyakova;Olesia Moskaliova;Irina Fridlanskaya

  • The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation

    Richard S. Saliba;Peter M. G. Munro;Philip J. Luthert;Michael E. Cheetham

  • Not all J domains are created equal: Implications for the specificity of Hsp40–Hsp70 interactions

    Fritha Hennessy;Williams S Nicoll;Richard Zimmermann;Michael E Cheetham

  • Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.

    Tracey A. Bailey;Naheed Kanuga;Ignacio A. Romero;John Greenwood

  • Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.

    David A. Parfitt;Amelia Lane;Conor M. Ramsden;Conor M. Ramsden;Amanda Jayne F Carr

  • The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

    Dimitra Athanasiou;Monica Aguila;James Bellingham;Wenwen Li

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

    Maria Borrell-Pagès;Josep M. Canals;Fabrice P. Cordelières;J. Alex Parker

  • MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

    Li F. Chan;Tom R. Webb;Teng-Teng Chung;Eirini Meimaridou

  • Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis

    Anneke I den Hollander;Robert K Koenekoop;Moin D Mohamed;Moin D Mohamed;Heleen H Arts

  • RPGR mutation associated with retinitis pigmentosa, impaired hearing, and sinorespiratory infections

    I Zito;S M Downes;R J Patel;M E Cheetham

  • Evidence of RPGRIP1 gene mutations associated with recessive cone-rod dystrophy

    A Hameed;A Abid;A Aziz;M Ismail

Frequent Co-Authors

Alison J. Hardcastle
Alison J. Hardcastle University College London
Andrew R. Webster
Andrew R. Webster University College London
Anthony T. Moore
Anthony T. Moore University of California, San Francisco
Brian H. Anderton
Brian H. Anderton King's College London
Graham E. Holder
Graham E. Holder University College London
Vincent Plagnol
Vincent Plagnol University College London
Keith R. Willison
Keith R. Willison Imperial College London
Uwe Wolfrum
Uwe Wolfrum Johannes Gutenberg University of Mainz
Shomi S. Bhattacharya
Shomi S. Bhattacharya University College London
Diane P. Hanger
Diane P. Hanger King's College London

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