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Biology and Biochemistry

D-Index
68
Citations
16071
World Ranking
7810
National Ranking
574

Overview

Uwe Wolfrum is affiliated with the Johannes Gutenberg University of Mainz in Germany with a research focus primarily in Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields including Molecular Biology, Cell Biology, Genetics, Immunology and Allergy, and Cellular and Molecular Neuroscience.

The scientist's research topics cover a variety of areas related to cellular and molecular processes and disease mechanisms. Main topics include:

  • Retinal Development and Disorders
  • Genetic and Kidney Cyst Diseases
  • Cell Adhesion Molecules Research
  • Cellular transport and secretion
  • Receptor Mechanisms and Signaling
  • RNA regulation and disease
  • RNA Research and Splicing

Uwe Wolfrum's recent publications reflect these themes. Selected papers include:

  • PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation, 2020, Proceedings of the National Academy of Sciences
  • Isolation and culturing of primary mouse astrocytes for the analysis of focal adhesion dynamics, 2021, STAR Protocols
  • Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions, 2021, iScience
  • Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes, 2022, EMBO Molecular Medicine
  • Autophagy interferes with human cytomegalovirus genome replication, morphogenesis, and progeny release, 2020, Autophagy

Frequent co-authors who have collaborated with Uwe Wolfrum include:

  • Joshua Linnert
  • Baran E. Güler
  • Kerstin Nagel-Wolfrum
  • Jacques S. Fritze
  • Karsten Boldt

The scientist's work has been published across several recurring venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cells
  • Frontiers in Cell and Developmental Biology
  • Basic & Clinical Pharmacology & Toxicology
  • Investigative Ophthalmology & Visual Science

Best Publications

  • Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1.

    Andrew W. Tai;Jen Zen Chuang;Christian Bode;Uwe Wolfrum

  • Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

    Martin Gamerdinger;Parvana Hajieva;A Murat Kaya;Uwe Wolfrum

  • Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle

    Batiste Boëda;Aziz El‐Amraoui;Amel Bahloul;Richard Goodyear

  • International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

    Jörg Hamann;Gabriela Aust;Demet Araç;Felix B. Engel

  • Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome

    Heleen H Arts;Dan Doherty;Sylvia E C van Beersum;Melissa A Parisi

  • How Does the Eye Breathe?: EVIDENCE FOR NEUROGLOBIN-MEDIATED OXYGEN SUPPLY IN THE MAMMALIAN RETINA *

    Marc J.J Schmidt;Andreas Giessl;Tilmann Laufs;Thomas Hankeln

  • Molecular basis of human Usher syndrome: Deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease

    Jan Reiners;Kerstin Nagel-Wolfrum;Karin Jürgens;Tina Märker

  • BAG3 mediates chaperone‐based aggresome‐targeting and selective autophagy of misfolded proteins

    Martin Gamerdinger;A Murat Kaya;Uwe Wolfrum;Albrecht M Clement

  • A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells

    Tina Maerker;Erwin van Wijk;Nora Overlack;Ferry F.J. Kersten

  • Usher syndrome: molecular links of pathogenesis, proteins and pathways

    Hannie Kremer;Erwin van Wijk;Tina Märker;Uwe Wolfrum

  • A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth

    Gaelle Lefèvre;Vincent Michel;Dominique Weil;Léa Lepelletier

  • Interactions in the network of Usher syndrome type 1 proteins

    Avital Adato;Vincent Michel;Yoshiaki Kikkawa;Jan Reiners

  • Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin–catenins complex

    Polonca Küssel-Andermann;Aziz El-Amraoui;Saaid Safieddine;Sylvie Nouaille

  • The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1

    Erwin van Wijk;Bert van der Zwaag;Theo Peters;Ulrike Zimmermann

  • An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes

    Gabrielle Wheway;Miriam Schmidts;Dorus A. Mans;Katarzyna Szymanska

  • Rhodopsin transport in the membrane of the connecting cilium of mammalian photoreceptor cells.

    Uwe Wolfrum;Angelika Schmitt

  • Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2

    Jan Reiners;Erwin van Wijk;Tina Märker;Ulrike Zimmermann

  • An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

    Boldt K;van Reeuwijk J;Lu Q;Koutroumpas K

  • Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis

    Anneke I den Hollander;Robert K Koenekoop;Moin D Mohamed;Moin D Mohamed;Heleen H Arts

  • Myosin VIIa, the product of the Usher 1B syndrome gene, is concentrated in the connecting cilia of photoreceptor cells.

    Xinran Liu;Gordon Vansant;Igor P. Udovichenko;Uwe Wolfrum

Frequent Co-Authors

Ronald Roepman
Ronald Roepman Radboud University
Hannie Kremer
Hannie Kremer Radboud University
marius ueffing
marius ueffing University of Tübingen
Peter Humphries
Peter Humphries Trinity College Dublin
Michael E. Cheetham
Michael E. Cheetham University College London
Andrew R. Webster
Andrew R. Webster University College London
Christian Behl
Christian Behl Johannes Gutenberg University of Mainz
Paul F. Kenna
Paul F. Kenna Trinity College Dublin
Anand Swaroop
Anand Swaroop National Institutes of Health
Oliver E. Blacque
Oliver E. Blacque University College Dublin

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