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Edward Darzynkiewicz

Edward Darzynkiewicz

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
11009
World Ranking
15043
National Ranking
20

Overview

Edward Darzynkiewicz is affiliated with the University of Warsaw in Poland and specializes in biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, with significant contributions across genetics, cancer research, cardiology, cardiovascular medicine, and physiology.

The scientist's work covers multiple topics related to RNA and protein synthesis mechanisms, RNA research and splicing, and RNA modifications and cancer. Additional areas of their research include RNA interference and gene delivery, biochemical and molecular research, cancer-related molecular mechanisms, and cancer-related gene regulation.

Frequent co-authors collaborating with Edward Darzynkiewicz include Renata Grzela, Anna Stankiewicz-Drogoń, Maciej Łukaszewicz, Karol Kurpiejewski, and Marzena Jankowska-Anyszka.

Publication venues where their research appears repeatedly include:

  • RNA
  • Nucleic Acids Research
  • Open Biology
  • International Journal of Molecular Sciences
  • Frontiers in Bioengineering and Biotechnology

Some of the recent publications by Edward Darzynkiewicz are:

  • Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation, 2021, Nucleic Acids Research
  • CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures, 2020, Open Biology
  • N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering, 2022, RNA
  • Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates, 2021, International Journal of Molecular Sciences
  • RNA sensor response in HeLa cells for transfected mRNAs prepared in vitro by SP6 and HiT7 RNA polymerases: A comparative study, 2022, Frontiers in Bioengineering and Biotechnology

Best Publications

  • MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F

    Géraldine Mathonnet;Marc R. Fabian;Yuri V. Svitkin;Armen Parsyan

  • A nuclear cap binding protein complex involved in pre-mRNA splicing

    Elisa Izaurralde;Joe Lewis;Caroline McGuigan;Marzena Jankowska

  • Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG.

    Janusz Stepinski;Clint Waddell;Ryszard Stolarski;Edward Darzynkiewicz

  • Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.

    Anna Niedzwiecka;Joseph Marcotrigiano;Janusz Stepinski;Marzena Jankowska-Anyszka

  • Novel “anti-reverse” cap analogs with superior translational properties

    Jacek Jemielity;Tolvert Fowler;Joanna Zuberek;Janusz Stepinski

  • The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal.

    Jörg Hamm;Edward Darzynkiewicz;Stanley M. Tahara;Iain W. Mattaj

  • Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209

    Bhavesh Joshi;Ai-Li Cai;Brett D. Keiper;Waldemar B. Minich

  • Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

    A N Kuhn;M Diken;S Kreiter;A Selmi

  • Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells.

    Ewa Grudzien-Nogalska;Jacek Jemielity;Joanna Kowalska;Edward Darzynkiewicz

  • Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency

    Ewa Grudzien;Janusz Stepinski;Marzena Jankowska-Anyszka;Ryszard Stolarski

  • A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs.

    E Izaurralde;J Stepinski;E Darzynkiewicz;I W Mattaj

  • Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport.

    U Fischer;E Darzynkiewicz;S M Tahara;N A Dathan

  • Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase.

    François Bélanger;Janusz Stepinski;Edward Darzynkiewicz;Jerry Pelletier

  • Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein.

    Joanna Zuberek;Aleksandra Wyslouch-Cieszynska;Anna Niedzwiecka;Michal Dadlez;Michal Dadlez

  • Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation.

    Aili Cai;Marzena Jankowska-Anyszka;Adrian Centers;Lidia Chlebicka

  • Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

    Joanna Kowalska;Magdalena Lewdorowicz;Joanna Zuberek;Ewa Grudzien-Nogalska

  • Most mRNAs in the nematode Ascaris lumbricoides are trans-spliced: a role for spliced leader addition in translational efficiency.

    Patricia A. Maroney;John A. Denker;Edward Darzynkiewicz;Ronald Laneve

  • mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2

    Mandar V. Deshmukh;Brittnee N. Jones;Duc-Uy Quang-Dang;Jeremy Flinders

  • Synthesis and use of anti-reverse mRNA cap analogues

    Edward Darzynkiewicz;Robert E. Rhoads;Janusz Stepinski

  • Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability.

    Ewa Grudzien-Nogalska;Janusz Stepinski;Jacek Jemielity;Joanna Zuberek

Frequent Co-Authors

Robert E. Rhoads
Robert E. Rhoads Louisiana State University
David Shugar
David Shugar Polish Academy of Sciences
Harri Lönnberg
Harri Lönnberg University of Turku
Ugur Sahin
Ugur Sahin Johannes Gutenberg University of Mainz
Michal Dadlez
Michal Dadlez Polish Academy of Sciences
Nahum Sonenberg
Nahum Sonenberg McGill University
Stephen Cusack
Stephen Cusack European Bioinformatics Institute
Iain W. Mattaj
Iain W. Mattaj Human Technopole
Ryszard Kierzek
Ryszard Kierzek Polish Academy of Sciences

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