What is he best known for?
The fields of study he is best known for:
- Enzyme
- Gene
- Organic chemistry
His primary areas of study are Biochemistry, Messenger RNA, Molecular biology, Protein biosynthesis and RNA Cap Analogs.
In general Biochemistry study, his work on Cap binding complex, Nucleotide and Methylation often relates to the realm of Small nuclear RNA, thereby connecting several areas of interest.
His study in Messenger RNA is interdisciplinary in nature, drawing from both RNA, In vitro and Stereochemistry.
His studies in Molecular biology integrate themes in fields like Phosphopeptide, Oligonucleotide and Cell biology.
The various areas that Edward Darzynkiewicz examines in his Cell biology study include Eukaryotic translation and Initiation factor.
His Protein biosynthesis research is multidisciplinary, relying on both Translational efficiency and Eukaryotic initiation factor 4F.
His most cited work include:
- MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F (452 citations)
- A nuclear cap binding protein complex involved in pre-mRNA splicing (427 citations)
- Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. (308 citations)
What are the main themes of his work throughout his whole career to date?
Edward Darzynkiewicz mostly deals with Messenger RNA, Biochemistry, Stereochemistry, EIF4E and RNA.
The study incorporates disciplines such as Molecular biology, Protein biosynthesis and Cell biology in addition to Messenger RNA.
His study in Cap binding complex, RNA Cap Analogs, DCPS, Nucleotide and Enzyme is carried out as part of his studies in Biochemistry.
He combines subjects such as Guanosine and Hydrolysis with his study of Stereochemistry.
As a part of the same scientific family, he mostly works in the field of EIF4E, focusing on Eukaryotic translation and, on occasion, Biophysics.
His study in the field of RNA splicing is also linked to topics like Five-prime cap and Small nuclear RNA.
He most often published in these fields:
- Messenger RNA (49.14%)
- Biochemistry (46.55%)
- Stereochemistry (38.36%)
What were the highlights of his more recent work (between 2013-2020)?
- Messenger RNA (49.14%)
- Biochemistry (46.55%)
- RNA (18.97%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Messenger RNA, Biochemistry, RNA, Translation and Cell biology.
In the subject of general Messenger RNA, his work in Eukaryotic translation and Eukaryotic Initiation Factor-4E is often linked to Conjugate, thereby combining diverse domains of study.
His is doing research in Cap binding complex, EIF4E, DCPS, Enzyme and Protein structure, both of which are found in Biochemistry.
EIF4E is closely attributed to Molecular biology in his work.
His RNA study combines topics from a wide range of disciplines, such as Methylation, Tetratricopeptide, Nucleotide, Translational Inhibition and NAD+ kinase.
RNA Cap Analogs is closely connected to Protein biosynthesis in his research, which is encompassed under the umbrella topic of Translation.
Between 2013 and 2020, his most popular works were:
- Structural analysis of human 2′- O -ribose methyltransferases involved in mRNA cap structure formation (54 citations)
- Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes (37 citations)
- eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei (35 citations)
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