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Biology and Biochemistry

D-Index
56
Citations
11675
World Ranking
14400
National Ranking
6062

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Megerditch Kiledjian is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily falls within the fields of Biochemistry, Genetics and Molecular Biology, with a specific focus on Molecular Biology. Additional subfields include Cell Biology, Spectroscopy, Ecology, and Physiology.

Their scientific contributions cover several main topics, including:

  • RNA modifications and cancer
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • Muscle Physiology and Disorders
  • Muscle metabolism and nutrition
  • Extracellular vesicles in disease
  • Circular RNAs in diseases

Some recent notable papers authored with Kiledjian include:

  • "SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer", 2021, Nature Communications
  • "Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs", 2020, Nucleic Acids Research
  • "DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs", 2020, Nucleic Acids Research
  • "Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA", 2022, Nature Communications
  • "InsP7is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics", 2020, Proceedings of the National Academy of Sciences

Frequent co-authors collaborating with Kiledjian include:

  • Sunny Sharma
  • Xinfu Jiao
  • Jun Yang
  • Ewa Grudzien-Nogalska
  • Liang Tong

Publication venues with multiple works by Kiledjian include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Nature Communications
  • Nature Cell Biology
  • Proceedings of the National Academy of Sciences

Kiledjian was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • Reversible methylation of m6Am in the 5′ cap controls mRNA stability

    Jan Mauer;Xiaobing Luo;Alexandre Blanjoie;Xinfu Jiao

  • Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

    M. Kiledjian;G. Dreyfuss

  • Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif

    Paula Henthorn;Megerditch Kiledjian;Tom Kadesch

  • The hDcp2 protein is a mammalian mRNA decapping enzyme.

    Zuoren Wang;Xinfu Jiao;Anne Carr-Schmid;Megerditch Kiledjian

  • Differential regulation of microRNA stability

    Sophie Bail;Mavis Swerdel;Hudan Liu;Xinfu Jiao

  • The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases

    Hudan Liu;Nancy D. Rodgers;Xinfu Jiao;Megerditch Kiledjian

  • Functional link between the mammalian exosome and mRNA decapping.

    Zuoren Wang;Megerditch Kiledjian

  • An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro.

    Zuoren Wang;Nancy Day;Panayiota Trifillis;Megerditch Kiledjian

  • Identification of two KH domain proteins in the alpha-globin mRNP stability complex.

    Megerditch Kiledjian;Xiaoming Wang;S. A. Liebhaber

  • Detection and characterization of a 3' untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability.

    Xiaoming Wang;M. Kiledjian;I. M. Weiss;S. A. Liebhaber

  • Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1

    Song Xiang;Amalene Cooper-Morgan;Xinfu Jiao;Megerditch Kiledjian

  • A long noncoding RNA associated with susceptibility to celiac disease

    Ainara Castellanos-Rubio;Nora Fernandez-Jimenez;Radomir Kratchmarov;Xiaobing Luo

  • Analysis of recombinant yeast decapping enzyme.

    Michelle Steiger;Anne Carr-Schmid;David C. Schwartz;Megerditch Kiledjian

  • Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex.

    Megerditch Kiledjian;Christine T. Demaria;Gary Brewer;Kristine Novick

  • 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding.

    Xinfu Jiao;Selom K. Doamekpor;Jeremy G. Bird;Bryce E. Nickels

  • Identification of a quality-control mechanism for mRNA 5′-end capping

    Xinfu Jiao;Song Xiang;ChanSeok Oh;Charles E. Martin

  • Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.

    Robert B. Wilson;Megerditch Kiledjian;Chun Pyn Shen;Robert Benezra

  • A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.

    Xinfu Jiao;Jeong Ho Chang;Turgay Kilic;Liang Tong

  • Multiple mRNA Decapping Enzymes in Mammalian Cells

    Man-Gen Song;You Li;Megerditch Kiledjian

  • New insights into decapping enzymes and selective mRNA decay

    Ewa Grudzien-Nogalska;Megerditch Kiledjian

Frequent Co-Authors

Liang Tong
Liang Tong Columbia University
Ronald P. Hart
Ronald P. Hart Rutgers, The State University of New Jersey
Richard H. Ebright
Richard H. Ebright Rutgers, The State University of New Jersey
Tom Kadesch
Tom Kadesch University of Pennsylvania
Smita S. Patel
Smita S. Patel Rutgers, The State University of New Jersey
Gideon Dreyfuss
Gideon Dreyfuss University of Pennsylvania
Stephen A. Liebhaber
Stephen A. Liebhaber University of Pennsylvania
John B. Vincent
John B. Vincent Centre for Addiction and Mental Health
Douglas C. Wallace
Douglas C. Wallace Children's Hospital of Philadelphia
Kang L. Wang
Kang L. Wang University of California, Los Angeles

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