World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
19028
World Ranking
10587
National Ranking
4598

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Yuan Zhuang is affiliated with Duke University in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research encompasses a variety of topics with a strong focus on molecular biology and immunology, cancer research, and molecular medicine.

The scientist has published on topics including:

  • Immune Cell Function and Interaction
  • Antibiotic Resistance in Bacteria
  • T-cell and B-cell Immunology
  • MicroRNA in disease regulation
  • Interferon and immune responses
  • Epigenetics and DNA Methylation
  • Advanced biosensing and bioanalysis techniques

Their work has appeared frequently in publication venues such as:

  • Research Square (Research Square)
  • SSRN Electronic Journal
  • Nature Communications
  • Journal of Global Antimicrobial Resistance
  • International Journal of Radiation Oncology*Biology*Physics

Zhuang's research has led to a number of published papers, including the following recent works:

  • Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging (2024, Cell)
  • Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription (2022, Journal of Experimental & Clinical Cancer Research)
  • Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p (2020, Journal of Cellular Physiology)
  • Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells (2021, Journal of Hepatocellular Carcinoma)
  • Anti-tumor effects of an ID antagonist with no observed acquired resistance (2021, npj Breast Cancer)

Collaborations have been a significant aspect of their research activity. Frequent co-authors include:

  • Zhao-Chong Zeng
  • Jun Feng
  • Jeremy Ratiu
  • Yixing Chen
  • Qun Wang

Yuan Zhuang's contributions to science have been recognized by their election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

  • The myoD gene family: nodal point during specification of the muscle cell lineage

    Harold Weintraub;Robert Davis;Stephen Tapscott;Matthew Thayer

  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

    David Lyden;Alison Z. Young;David Zagzag;Wei Yan

  • Efficient Transposition of the piggyBac (PB) Transposon in Mammalian Cells and Mice

    Sheng Ding;Xiaohui Wu;Gang Li;Min Han;Min Han

  • A compensatory base change in U1 snRNA suppresses a 5' splice site mutation

    Yuan Zhuang;Alan M. Weiner

  • The helix-loop-helix gene E2A is required for B cell formation

    Yuan Zhuang;Philippe Soriano;Harold Weintraub

  • Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development

    Babacar Cisse;Michele L. Caton;Manfred Lehner;Takahiro Maeda

  • Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

    Michael B. Datto;Joshua P. Frederick;Lihua Pan;Anita J. Borton

  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

    Xiaochang Zhang;Kai Lei;Xiaobing Yuan;Xiaohui Wu

  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

    Y Zhuang;P Cheng;H Weintraub

  • Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

    Steven Fiering;Elliot Epner;Kirsten Robinson;Yuan Zhuang

  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.

    Xu Ding;Rener Xu;Juehua Yu;Tian Xu;Tian Xu

  • A compensatory base change in human U2 snRNA can suppress a branch site mutation.

    Yuan Zhuang;Alan M. Weiner

  • Mekk3 is essential for early embryonic cardiovascular development

    Jianhua Yang;Melynda Boerm;Marya McCarty;Corazon Bucana

  • Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

    Xiaochang Zhang;Rener Xu;Binggen Zhu;Xiujuan Yang

  • High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.

    W Yan;A Z Young;V C Soares;R Kelley

  • SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.

    Kai Lei;Xiaochang Zhang;Xu Ding;Xue Guo

  • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.

    Robert J. Barndt;Meifang Dai;Yuan Zhuang

  • Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene

    Lihua Pan;Shinichi Sato;Joshua P. Frederick;Xiao Hong Sun

  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

    Lih Yun Hsu;Josh Lauring;Hong Erh Liang;Stephen Greenbaum

  • Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

    Yumi Yashiro-Ohtani;Yiping He;Takuya Ohtani;Mary E. Jones

Frequent Co-Authors

Tian Xu
Tian Xu Westlake University
Min Han
Min Han University of Colorado Boulder
Qi-Jing Li
Qi-Jing Li Duke University
Robert Benezra
Robert Benezra Memorial Sloan Kettering Cancer Center
Antonio Iavarone
Antonio Iavarone Columbia University Medical Center
David B. Dunson
David B. Dunson Duke University
Kun-Liang Guan
Kun-Liang Guan Westlake University
Harold Weintraub
Harold Weintraub Fred Hutchinson Cancer Research Center
Shawn Levy
Shawn Levy Vanderbilt University
Alan M. Weiner
Alan M. Weiner University of Washington

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