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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Genetics

D-Index
114
Citations
57969
World Ranking
463
National Ranking
239

Molecular Biology

D-Index
114
Citations
57969
World Ranking
317
National Ranking
191

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2006 - Fellow of the American Academy of Arts and Sciences
  • 2003 - Member of the National Academy of Medicine (NAM)
  • 2001 - Member of the National Academy of Sciences
  • 1994 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Mark Groudine is affiliated with the Fred Hutchinson Cancer Research Center in the United States, where their research primarily focuses on biochemistry, genetics, and molecular biology. Their work spans several subfields, including molecular biology, plant science, genetics, cancer research, and infectious diseases.

Their scholarly contributions cover various topics, notably in genomics and chromatin dynamics, RNA research and splicing, chromosomal and genetic variations, cancer genomics and diagnostics, RNA and protein synthesis mechanisms, and HIV research and treatment.

Mark Groudine's frequent publication venues include:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Nature Communications

Key recent papers authored or co-authored by Mark Groudine are:

  • "HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics," 2021, eLife
  • "Tissue context determines the penetrance of regulatory DNA variation," 2021, Nature Communications
  • "HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Atlas and developmental dynamics of mouse DNase I hypersensitive sites," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts," 2020, UNC Libraries

Frequent co-authors collaborating with Mark Groudine include:

  • Jessica Halow
  • M. A. Bender
  • J Stamatoyannopoulos
  • Héctor Rincón-Arano
  • Scott B. Rothbart

Mark Groudine's recognition in the scientific community is reflected by several honors. They were elected a Fellow of the American Association for the Advancement of Science (AAAS) in 1994.

Further accolades include membership in prestigious academies:

  • Member of the National Academy of Sciences, 2001
  • Member of the National Academy of Medicine (NAM), 2003
  • Fellow of the American Academy of Arts and Sciences, 2006

Best Publications

  • Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

    Erez Lieberman-Aiden;Nynke L. van Berkum;Louise Williams;Maxim Imakaev

  • An integrated encyclopedia of DNA elements in the human genome

    Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins

  • Chromosomal subunits in active genes have an altered conformation

    Harold Weintraub;Mark Groudine

  • A comparative encyclopedia of DNA elements in the mouse genome

    Feng Yue;Feng Yue;Yong Cheng;Alessandra Breschi;Jeff Vierstra

  • Controlling the double helix

    Gary Felsenfeld;Mark Groudine;Mark Groudine

  • Cyclin E-CDK2 is a regulator of p27Kip1.

    Robert J. Sheaff;Mark Groudine;Matthew Gordon;James M. Roberts

  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

    Dirk Schübeler;David M. MacAlpine;David Scalzo;Christiane Wirbelauer

  • A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells.

    David L. Bentley;Mark Groudine

  • Functional and Mechanistic Diversity of Distal Transcription Enhancers

    Michael Bulger;Mark Groudine;Mark Groudine

  • An expansive human regulatory lexicon encoded in transcription factor footprints

    Shane Neph;Jeff Vierstra;Andrew B. Stergachis;Alex P. Reynolds

  • Transcriptional regulation of hemoglobin switching in chicken embryos.

    M Groudine;M Peretz;H Weintraub

  • Control of c-myc regulation in normal and neoplastic cells.

    Charlotte A. Spencer;Mark Groudine;Mark Groudine

  • Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line.

    Steven Collins;Mark Groudine;Mark Groudine

  • Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.

    Bruce E. Clurman;Robert J. Sheaff;Kenneth Thress;Mark Groudine

  • Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

    Christopher R. Vakoc;Danielle L. Letting;Danielle L. Letting;Nele Gheldof;Tomoyuki Sawado

  • Looping versus linking: toward a model for long-distance gene activation

    Michael Bulger;Mark Groudine

  • A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

    W C Forrester;E Epner;M C Driscoll;T Enver

  • Enhanced transcription of c-myc in bursal lymphoma cells requires continuous protein synthesis

    Maxine Linial;Nancy Gunderson;Mark Groudine;Mark Groudine

  • Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

    Mark Groudine;Robert Eisenman;Harold Weintraub

  • Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells.

    Matthew C Lorincz;David R Dickerson;Mike Schmitt;Mark Groudine;Mark Groudine

Frequent Co-Authors

Harold Weintraub
Harold Weintraub Fred Hutchinson Cancer Research Center
Dirk Schübeler
Dirk Schübeler Friedrich Miescher Institute
John A. Stamatoyannopoulos
John A. Stamatoyannopoulos University of Washington
Richard Sandstrom
Richard Sandstrom University of Washington
David I. K. Martin
David I. K. Martin UCSF Benioff Children's Hospital
Ross C. Hardison
Ross C. Hardison Pennsylvania State University
Stephen J. Tapscott
Stephen J. Tapscott Fred Hutchinson Cancer Research Center
Stuart H. Orkin
Stuart H. Orkin Harvard University
Michael Snyder
Michael Snyder Stanford University

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