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Genetics

D-Index
83
Citations
24811
World Ranking
1421
National Ranking
671

Overview

Gerd A. Blobel is affiliated with the Children's Hospital of Philadelphia in the United States. Their research spans a wide array of topics within biochemistry, genetics, and molecular biology, with additional contributions to medicine.

The primary fields of study highlighted in their work include biochemistry, genetics and molecular biology, and medicine. More specifically, their research covers subfields such as molecular biology, genetics, hematology, physiology, and pediatrics, perinatology, and child health.

The scientist has contributed extensively to research on topics such as:

  • Genomics and chromatin dynamics
  • Hemoglobinopathies and related disorders
  • RNA research and splicing
  • Epigenetics and DNA methylation
  • RNA modifications and cancer
  • Erythrocyte function and pathophysiology
  • RNA and protein synthesis mechanisms

Among recent notable publications are:

  • "Testing the super-enhancer concept," 2021, Nature Reviews Genetics
  • "Distinct properties and functions of CTCF revealed by a rapidly inducible degron system," 2021, Cell Reports
  • "Efficient engineering of human and mouse primary cells using peptide-assisted genome editing," 2023, Nature Biotechnology
  • "BRD4 orchestrates genome folding to promote neural crest differentiation," 2021, Nature Genetics
  • "ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression," 2020, Molecular Cell

Frequent coauthors in their research include:

  • Cheryl A. Keller
  • Ross C. Hardison
  • Belinda Giardine
  • Junwei Shi
  • Eugene Khandros

Publications by this scientist have appeared predominantly in venues such as:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Molecular Cell
  • Journal of Biological Chemistry

Best Publications

  • A comparative encyclopedia of DNA elements in the mouse genome

    Feng Yue;Feng Yue;Yong Cheng;Alessandra Breschi;Jeff Vierstra

  • Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

    Fan Lai;Ulf A. Orom;Matteo Cesaroni;Malte Beringer

  • Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin

    Christopher R. Vakoc;Sean A. Mandat;Benjamin A. Olenchock;Gerd A. Blobel;Gerd A. Blobel

  • Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

    Wulan Deng;Wulan Deng;Jongjoo Lee;Hongxin Wang;Jeff Miller

  • Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

    Christopher R. Vakoc;Danielle L. Letting;Danielle L. Letting;Nele Gheldof;Tomoyuki Sawado

  • DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.

    David J. Steger;Martina I. Lefterova;Lei Ying;Aaron J. Stonestrom

  • An encyclopedia of mouse DNA elements (Mouse ENCODE)

    John A Stamatoyannopoulos;Michael Snyder;Ross Hardison;Bing Ren

  • Global regulation of erythroid gene expression by transcription factor GATA-1

    John J. Welch;Jason A. Watts;Christopher R. Vakoc;Yu Yao

  • Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

    Junwei Shi;Warren A. Whyte;Cinthya J. Zepeda-Mendoza;Cinthya J. Zepeda-Mendoza;Joseph P. Milazzo

  • Reactivation of developmentally silenced globin genes by forced chromatin looping.

    Wulan Deng;Wulan Deng;Jeremy W. Rupon;Ivan Krivega;Laura Breda

  • GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.

    Todd Gregory;Channing Yu;Averil Ma;Stuart H. Orkin

  • Profile of histone lysine methylation across transcribed mammalian chromatin

    Christopher R. Vakoc;Mira M. Sachdeva;Hongxin Wang;Gerd A. Blobel;Gerd A. Blobel

  • CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

    Gerd A. Blobel;Toshihiro Nakajima;Richard Eckner;Marc Montminy

  • The c-MYC Oncoprotein Is a Substrate of the Acetyltransferases hGCN5/PCAF and TIP60

    Jagruti H. Patel;Yanping Du;Penny G. Ard;Charles Phillips

  • An abundant erythroid protein that stabilizes free α-haemoglobin

    Anthony J. Kihm;Anthony J. Kihm;Yi Kong;Yi Kong;Wei Hong;Wei Hong;J. Eric Russell;J. Eric Russell

  • GATA Transcription Factors and Cancer

    Rena Zheng;Gerd A. Blobel

  • Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping

    Caroline R. Bartman;Sarah C. Hsu;Sarah C. Hsu;Chris C.-S. Hsiung;Chris C.-S. Hsiung;Arjun Raj

  • A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

    Elizabeth A. Traxler;Elizabeth A. Traxler;Yu Yao;Yong Dong Wang;Kaitly J. Woodard

  • Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus

    Huie Jing;Christopher R. Vakoc;Lei Ying;Sean Mandat

  • CREB-binding protein and p300: molecular integrators of hematopoietic transcription

    Gerd A. Blobel

Frequent Co-Authors

Ross C. Hardison
Ross C. Hardison Pennsylvania State University
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Christopher R. Vakoc
Christopher R. Vakoc Cold Spring Harbor Laboratory
Mortimer Poncz
Mortimer Poncz Children's Hospital of Philadelphia
Arjun Raj
Arjun Raj University of Pennsylvania
Joel P. Mackay
Joel P. Mackay University of Sydney
James Hughes
James Hughes Emory University
David M. Bodine
David M. Bodine National Institutes of Health
Mark Groudine
Mark Groudine Fred Hutchinson Cancer Research Center

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