World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
90
Citations
30854
World Ranking
733
National Ranking
396

Overview

Mitchell J. Weiss is affiliated with St. Jude Children's Research Hospital in the United States. The research focus spans core areas in Medicine as well as Biochemistry, Genetics, and Molecular Biology, reflecting a broad engagement with molecular and genetic aspects of health and disease.

The scientist's subfields of study include:

  • Molecular Biology
  • Genetics
  • Hematology
  • Pediatrics, Perinatology and Child Health
  • Cancer Research

Research topics covered in their work include:

  • Hemoglobinopathies and Related Disorders
  • Epigenetics and DNA Methylation
  • Prenatal Screening and Diagnostics
  • CRISPR and Genetic Engineering
  • RNA modifications and cancer
  • Erythrocyte Function and Pathophysiology
  • Iron Metabolism and Disorders

Recent publications illustrate contributions to genetics, molecular biology, and pediatric cancer research. Notable papers include:

  • Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing, 2021, Nature Genetics
  • Base editing of haematopoietic stem cells rescues sickle cell disease in mice, 2021, Nature
  • St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem, 2021, Cancer Discovery
  • Erythropoietin regulation of red blood cell production: from bench to bedside and back, 2020, F1000Research
  • ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression, 2020, Molecular Cell

The scientist frequently collaborates with a group of coauthors, including:

  • Yu Yao
  • Jonathan Yen
  • Thiyagaraj Mayuranathan
  • Ruopeng Feng
  • Kalin Mayberry

Publishing is mostly concentrated in a few key academic venues:

  • Blood
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood Advances
  • Nature Genetics

Best Publications

  • A comparative encyclopedia of DNA elements in the mouse genome

    Feng Yue;Feng Yue;Yong Cheng;Alessandra Breschi;Jeff Vierstra

  • An early haematopoietic defect in mice lacking the transcription factor GATA-2.

    Fong-Ying Tsai;Fong-Ying Tsai;Gordon Keller;Frank C. Kuo;Mitchell Weiss

  • FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

    Alice P Tsang;Jane E Visvader;C.Alexander Turner;Yuko Fujiwara;Yuko Fujiwara

  • Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.

    Mitchell J. Weiss;Gordon Keller;Stuart H. Orkin

  • Mitoferrin is essential for erythroid iron assimilation

    George C. Shaw;John J. Cope;John J. Cope;Liangtao Li;Kenneth Corson

  • Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

    Christopher R. Vakoc;Danielle L. Letting;Danielle L. Letting;Nele Gheldof;Tomoyuki Sawado

  • GATA transcription factors: key regulators of hematopoiesis.

    M J Weiss;S H Orkin

  • Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1.

    Kim E. Nichols;John D. Crispino;Mortimer Poncz;James G. White

  • Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene

    Qingde Wang;Mana Miyakoda;Weidong Yang;Jaspal Khillan

  • An encyclopedia of mouse DNA elements (Mouse ENCODE)

    John A Stamatoyannopoulos;Michael Snyder;Ross Hardison;Bing Ren

  • Global regulation of erythroid gene expression by transcription factor GATA-1

    John J. Welch;Jason A. Watts;Christopher R. Vakoc;Yu Yao

  • Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase.

    Mitchell J. Weiss;Paula S. Henthorn;Mary Ann Lafferty;Clive Slaughter

  • Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.

    S Davis;M J Weiss;J R Wong;T J Lampidis

  • GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.

    Todd Gregory;Channing Yu;Averil Ma;Stuart H. Orkin

  • Structure of the human liver/bone/kidney alkaline phosphatase gene.

    M. J. Weiss;K. Ray;P. S. Henthorn;Bruce Lamb

  • GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling.

    Jeffrey A. Grass;Meghan E. Boyer;Saumen Pal;Jing Wu

  • Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line.

    M J Weiss;C Yu;S H Orkin

  • A GATA-1-regulated microRNA locus essential for erythropoiesis

    Louis C. Dore;Julio D. Amigo;Camila O. dos Santos;Zhe Zhang

  • Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.

    Mitchell J. Weiss;Stuart H. Orkin

  • Identification of the receptor scavenging hemopexin-heme complexes. Commentary

    Vibeke Hvidberg;Maciej B. Maniecki;Christian Jacobsen;Peter Højrup

Frequent Co-Authors

Gerd A. Blobel
Gerd A. Blobel Children's Hospital of Philadelphia
Ross C. Hardison
Ross C. Hardison Pennsylvania State University
Deborah L. French
Deborah L. French Children's Hospital of Philadelphia
Stuart H. Orkin
Stuart H. Orkin Harvard University
David M. Bodine
David M. Bodine National Institutes of Health
Joel P. Mackay
Joel P. Mackay University of Sydney
John D. Crispino
John D. Crispino Northwestern University
Andrew J. Gow
Andrew J. Gow Rutgers, The State University of New Jersey
Mortimer Poncz
Mortimer Poncz Children's Hospital of Philadelphia
Gang Wu
Gang Wu Washington University in St. Louis

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