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Biology and Biochemistry

D-Index
60
Citations
12348
World Ranking
11998
National Ranking
5148

Overview

Deborah L. French is affiliated with the Children's Hospital of Philadelphia in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions to Medicine. Subfields of study include Molecular Biology, Hematology, Genetics, Surgery, and Immunology.

Their work covers a range of scientific topics, notably:

  • Platelet Disorders and Treatments
  • Acute Myeloid Leukemia Research
  • Pluripotent Stem Cells Research
  • Single-cell and spatial transcriptomics
  • CRISPR and Genetic Engineering
  • Pancreatic function and diabetes
  • Congenital heart defects research

Deborah L. French has coauthored extensively with several researchers, including:

  • Alyssa Gagne
  • Paul Gadue
  • Jean Ann Maguire
  • Stella T. Chou
  • Elisa A. Waxman

Their research has been published in numerous scientific venues, with frequent publications in:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Stem Cell Research
  • Stem Cell Reports
  • Experimental Hematology

Among recent papers authored or coauthored by Deborah L. French are:

  • PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes, 2022, Cell Stem Cell
  • Rigor and reproducibility in human brain organoid research: Where we are and where we need to go, 2024, Stem Cell Reports
  • RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells, 2021, Blood
  • Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching, 2023, Nature Communications
  • Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model, 2021, Stem Cell Reports

Best Publications

  • Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

    Noemi Ramos-DeSimone;Elizabeth Hahn-Dantona;John Sipley;Hideaki Nagase

  • Germline genomic variants associated with childhood acute lymphoblastic leukemia.

    Lisa R Treviño;Wenjian Yang;Deborah French;Stephen P Hunger

  • Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette

    Aba Somers;Jyh‐Chang Jean;Cesar A. Sommer;Amel Omari

  • Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro.

    C. L. Librach;S. L. Feigenbaum;K. E. Bass;Tian-Yi Cui

  • The role of somatic hypermutation in the generation of antibody diversity

    Deborah L. French;Reuven Laskov;Matthew D. Scharff

  • Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro

    H. William Schnaper;H. William Schnaper;Derrick S. Grant;William G. Stetler-Stevenson;Rafael Fridman

  • HUMAN DEFINITIVE HAEMOGENIC ENDOTHELIUM AND ARTERIAL VASCULAR ENDOTHELIUM REPRESENT DISTINCT LINEAGES

    Andrea Ditadi;Christopher M Sturgeon;Joanna Tober;Geneve Awong

  • Self-renewing endodermal progenitor lines generated from human pluripotent stem cells.

    Xin Cheng;Lei Ying;Lin Lu;Aline M. Galvão

  • Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia

    Jun J. Yang;Cheng Cheng;Wenjian Yang;Deqing Pei

  • Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

    Stocco G;Stocco G;Cheok Mh;Crews Kr;Dervieux T

  • Ancestry and pharmacogenetics of antileukemic drug toxicity.

    Shinji Kishi;Cheng Cheng;Deborah French;Deqing Pei

  • Correlation of the in situ detection of polymerase chain reaction-amplified metalloproteinase complementary DNAs and their inhibitors with prognosis in cervical carcinoma.

    Gerard J. Nuovo;Phyllis B. MacConnell;Aylin Simsir;Fidel Valea

  • Markedly Elevated Serum MMP-9 (Gelatinase B) Levels in Rheumatoid Arthritis: A Potentially Useful Laboratory Marker

    Barry L. Gruber;Darius Sorbi;Darius Sorbi;Deborah L. French;Deborah L. French;Mary J. Marchese;Mary J. Marchese

  • A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

    Ilenia Simeoni;Ilenia Simeoni;Jonathan C. Stephens;Jonathan C. Stephens;Fengyuan Hu;Fengyuan Hu;Sri V V Deevi;Sri V V Deevi

  • Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.

    Zuping Zhou;Deborah L. French;G. E. Ma;Samuel Eisenstein

  • Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-α-stimulated Transcription Factor ISGF3

    Margarita Martinez-Moczygemba;Michael J. Gutch;Deborah L. French;Nancy C. Reich

  • Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.

    Alan Hb Wu;Roy Gerona;Patil Armenian;Deborah French

  • The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation.

    Brenden W. Smith;Brenden W. Smith;Sarah S. Rozelle;Sarah S. Rozelle;Amy Leung;Amy Leung;Jessalyn Ubellacker

  • A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group

    Deborah French;Leo H. Hamilton;Leonard A. Mattano;Harland N. Sather

  • PharmGKB summary: methotrexate pathway.

    Torben S. Mikkelsen;Caroline F. Thorn;Jun J. Yang;Cornelia M. Ulrich

Frequent Co-Authors

Mortimer Poncz
Mortimer Poncz Children's Hospital of Philadelphia
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital
Alan H.B. Wu
Alan H.B. Wu University of California, San Francisco
William E. Evans
William E. Evans St. Jude Children's Research Hospital
Ching-Hon Pui
Ching-Hon Pui St. Jude Children's Research Hospital
Lisa M. Sullivan
Lisa M. Sullivan Boston University
James R. Downing
James R. Downing St. Jude Children's Research Hospital
James P. Quigley
James P. Quigley Scripps Research Institute
Monica Bessler
Monica Bessler Children's Hospital of Philadelphia

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