What is he best known for?
The fields of study he is best known for:
His primary areas of study are Molecular biology, Transcription factor, Gene, Genetics and Transcription.
His Molecular biology research incorporates elements of Embryonic stem cell, Haematopoiesis, GATA transcription factor, Regulation of gene expression and Erythroid-Specific DNA-Binding Factors.
James Douglas Engel connects Transcription factor with Antioxidant Response Elements in his research.
His work on Gene expression, Globin, Consensus sequence and Structural gene as part of general Gene study is frequently linked to Yeast artificial chromosome, bridging the gap between disciplines.
His studies examine the connections between Transcription and genetics, as well as such issues in Transgene, with regards to Bacterial artificial chromosome, Mammalian embryology, Sympathoadrenal system and Kidney metabolism.
His Conserved sequence study incorporates themes from KEAP1 and NFE2L2.
His most cited work include:
- Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain (2507 citations)
- Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain (2507 citations)
- Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation (631 citations)
What are the main themes of his work throughout his whole career to date?
James Douglas Engel focuses on Molecular biology, Gene, Genetics, Transcription factor and Enhancer.
His Molecular biology research includes elements of Gene expression, Cellular differentiation, Transgene, Globin and Exon.
His Transgene research focuses on subjects like Mutant, which are linked to Mutation.
Gene connects with themes related to DNA in his study.
His Locus, Regulation of gene expression, Locus control region and Chromatin study in the realm of Genetics connects with subjects such as Yeast artificial chromosome.
His Transcription factor research is multidisciplinary, relying on both Response element and Cell biology.
He most often published in these fields:
- Molecular biology (43.08%)
- Gene (40.00%)
- Genetics (33.08%)
What were the highlights of his more recent work (between 2011-2021)?
- Molecular biology (43.08%)
- Genetics (33.08%)
- Cell biology (16.54%)
In recent papers he was focusing on the following fields of study:
James Douglas Engel spends much of his time researching Molecular biology, Genetics, Cell biology, Fetal hemoglobin and Erythropoiesis.
His biological study spans a wide range of topics, including Transgene, GATA2, Globin, Regulation of gene expression and Kidney.
The concepts of his Regulation of gene expression study are interwoven with issues in Chromatin and Testicular receptor 4, Nuclear receptor, Transcription factor.
His work is connected to Gene, Locus, GATA1, Transvection and Human genome, as a part of Genetics.
His work in Cell biology addresses subjects such as Bone marrow, which are connected to disciplines such as Downregulation and upregulation, Cluster of differentiation, Sinusoid and Transferrin receptor.
His research investigates the link between Erythropoiesis and topics such as Coactivator that cross with problems in Transcriptional regulation.
Between 2011 and 2021, his most popular works were:
- Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals (251 citations)
- Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks (219 citations)
- Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction (131 citations)
In his most recent research, the most cited papers focused on:
James Douglas Engel mainly investigates Fetal hemoglobin, Molecular biology, Genetics, Regulation of gene expression and Cell.
The study incorporates disciplines such as Anemia, Pharmacology and Demethylase in addition to Fetal hemoglobin.
His Molecular biology research integrates issues from Transgene, GATA2, Enhancer and Kidney, Renal medulla.
Genetics is a component of his MYB, Locus, Gene, Intron and Transcription factor studies.
James Douglas Engel connects Regulation of gene expression with Antioxidant Response Elements in his study.
His Cell study also includes fields such as
- Decitabine and Erythropoiesis most often made with reference to Immunology,
- Inflammation, which have a strong connection to Cell adhesion molecule, KEAP1, Oxidative stress and Sirolimus,
- Hemolysis that intertwine with fields like Mitochondrion, PI3K/AKT/mTOR pathway and Mitophagy.
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