1999 - Fellow of the American Association for the Advancement of Science (AAAS)
His primary areas of study are Molecular biology, Transcription factor, Gene, Genetics and Transcription. His Molecular biology research incorporates elements of Embryonic stem cell, Haematopoiesis, GATA transcription factor, Regulation of gene expression and Erythroid-Specific DNA-Binding Factors. James Douglas Engel connects Transcription factor with Antioxidant Response Elements in his research.
His work on Gene expression, Globin, Consensus sequence and Structural gene as part of general Gene study is frequently linked to Yeast artificial chromosome, bridging the gap between disciplines. His studies examine the connections between Transcription and genetics, as well as such issues in Transgene, with regards to Bacterial artificial chromosome, Mammalian embryology, Sympathoadrenal system and Kidney metabolism. His Conserved sequence study incorporates themes from KEAP1 and NFE2L2.
James Douglas Engel focuses on Molecular biology, Gene, Genetics, Transcription factor and Enhancer. His Molecular biology research includes elements of Gene expression, Cellular differentiation, Transgene, Globin and Exon. His Transgene research focuses on subjects like Mutant, which are linked to Mutation.
Gene connects with themes related to DNA in his study. His Locus, Regulation of gene expression, Locus control region and Chromatin study in the realm of Genetics connects with subjects such as Yeast artificial chromosome. His Transcription factor research is multidisciplinary, relying on both Response element and Cell biology.
James Douglas Engel spends much of his time researching Molecular biology, Genetics, Cell biology, Fetal hemoglobin and Erythropoiesis. His biological study spans a wide range of topics, including Transgene, GATA2, Globin, Regulation of gene expression and Kidney. The concepts of his Regulation of gene expression study are interwoven with issues in Chromatin and Testicular receptor 4, Nuclear receptor, Transcription factor.
His work is connected to Gene, Locus, GATA1, Transvection and Human genome, as a part of Genetics. His work in Cell biology addresses subjects such as Bone marrow, which are connected to disciplines such as Downregulation and upregulation, Cluster of differentiation, Sinusoid and Transferrin receptor. His research investigates the link between Erythropoiesis and topics such as Coactivator that cross with problems in Transcriptional regulation.
James Douglas Engel mainly investigates Fetal hemoglobin, Molecular biology, Genetics, Regulation of gene expression and Cell. The study incorporates disciplines such as Anemia, Pharmacology and Demethylase in addition to Fetal hemoglobin. His Molecular biology research integrates issues from Transgene, GATA2, Enhancer and Kidney, Renal medulla.
Genetics is a component of his MYB, Locus, Gene, Intron and Transcription factor studies. James Douglas Engel connects Regulation of gene expression with Antioxidant Response Elements in his study. His Cell study also includes fields such as
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Molecular cloning–A laboratory manual. New York: Cold Spring Harbor Laboratory. 1982, 545 S., 42 $
T. Mamiatis;E. F. Fritsch;J. Sambrook;J. Engel.
Acta Biotechnologica (1985)
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii.
Genes & Development (1999)
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Nobunao Wakabayashi;Ken Itoh;Junko Wakabayashi;Hozumi Motohashi.
Nature Genetics (2003)
DNA-binding specificities of the GATA transcription factor family.
L J Ko;J D Engel.
Molecular and Cellular Biology (1993)
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.
Pier Paolo Pandolfi;Pier Paolo Pandolfi;Matthew E. Roth;Alar Karis;Alar Karis;Mark W. Leonard.
Nature Genetics (1995)
Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.
Masayuki Yamamoto;Linda J. Ko;Mark W. Leonard;Hartmut Beug.
Genes & Development (1990)
MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion
Chuan Zhang;Takashi Moriguchi;Takashi Moriguchi;Miwako Kajihara;Ritsuko Esaki.
Molecular and Cellular Biology (2005)
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.
Hozumi Motohashi;Tania O'Connor;Fumiki Katsuoka;James Douglas Engel.
Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I
Jurg Stalder;Alf Larsen;James D. Engel;Maureen Dolan.
A 200 base pair region at the 5′ end of the chicken adult β-globin gene is accessible to nuclease digestion
James D. McGhee;William I. Wood;Maureen Dolan;James Douglas Engel.
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