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D-Index & Metrics

Molecular Biology

D-Index
94
Citations
97993
World Ranking
642
National Ranking
351

Research.com Recognitions

  • 1999 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

James Douglas Engel is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans primarily in the fields of Biochemistry, Genetics and Molecular Biology, with notable contributions also to Medicine.

Their body of work includes significant involvement in subfields such as Molecular Biology, Genetics, Hematology, Physiology, and Immunology. Research topics frequently covered by Engel include Hemoglobinopathies and Related Disorders, Epigenetics and DNA Methylation, Erythrocyte Function and Pathophysiology, RNA modifications and cancer, Cancer-related gene regulation, CRISPR and Genetic Engineering, and Immune cells in cancer.

Engel has published extensively in prominent scientific venues. Frequent publication venues include Blood, Blood Advances, bioRxiv (Cold Spring Harbor Laboratory), Developmental Cell, and Experimental Hematology. The volume of publications across these venues highlights their focus on hematology and molecular biology research.

Recent notable papers authored by Engel include:

  • In situ mapping identifies distinct vascular niches for myelopoiesis, 2021, Nature
  • Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia, 2021, Developmental Cell
  • Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq, 2022, Cell Discovery
  • An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation, 2021, Blood
  • EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis, 2020, Blood Advances

Engel's collaborative network includes frequent co-authors such as Greggory Myers, Rami Khoriaty, Sharon Singh, Lei Yu, and Ginette Balbin-Cuesta, indicating an active engagement with researchers in related areas.

In recognition of their contributions, Engel was named a Fellow of the American Association for the Advancement of Science (AAAS) in 1999.

Best Publications

  • Molecular cloning–A laboratory manual. New York: Cold Spring Harbor Laboratory. 1982, 545 S., 42 $

    T. Mamiatis;E. F. Fritsch;J. Sambrook;J. Engel

  • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

    Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii

  • Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

    Nobunao Wakabayashi;Ken Itoh;Junko Wakabayashi;Hozumi Motohashi

  • DNA-binding specificities of the GATA transcription factor family.

    L J Ko;J D Engel

  • Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.

    Pier Paolo Pandolfi;Pier Paolo Pandolfi;Matthew E. Roth;Alar Karis;Alar Karis;Mark W. Leonard

  • Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

    Masayuki Yamamoto;Linda J. Ko;Mark W. Leonard;Hartmut Beug

  • MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion

    Chuan Zhang;Takashi Moriguchi;Takashi Moriguchi;Miwako Kajihara;Ritsuko Esaki

  • Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.

    Hozumi Motohashi;Tania O'Connor;Fumiki Katsuoka;James Douglas Engel

  • Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I

    Jurg Stalder;Alf Larsen;James D. Engel;Maureen Dolan

  • A 200 base pair region at the 5′ end of the chicken adult β-globin gene is accessible to nuclease digestion

    James D. McGhee;William I. Wood;Maureen Dolan;James Douglas Engel

  • Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

    Yosuke Hirotsu;Fumiki Katsuoka;Ryo Funayama;Takeshi Nagashima

  • Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals

    Masao Nagasaki;Jun Yasuda;Fumiki Katsuoka;Naoki Nariai

  • Developmental regulation of β-globin gene switching

    Ok-Ryun Baik Choi;James Douglas Engel

  • Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway

    Hozumi Motohashi;Fumiki Katsuoka;James Douglas Engel;Masayuki Yamamoto

  • Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.

    Kim Chew Lim;Ganesh Lakshmanan;Susan E. Crawford;Yi Gu

  • Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-Dependent Genes

    Fumiki Katsuoka;Hozumi Motohashi;Tetsuro Ishii;Hiroyuki Aburatani

  • Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis

    Etsuro Ito;Tsutomu Toki;Hajime Ishihara;Haruo Ohtani

  • The world according to Maf

    Hozumi Motohashi;Jordan A. Shavit;Kazuhiko Igarashi;Masayuki Yamamoto

  • Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

    Linda J. Ko;Masayuki Yamamoto;Mark W. Leonard;Kathleen M. George

  • Dynamics of GATA transcription factor expression during erythroid differentiation

    Mark Leonard;Martha Brice;James Douglas Engel;Thalia Papayannopoulou

Frequent Co-Authors

Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Satoru Takahashi
Satoru Takahashi University of Tsukuba
Hozumi Motohashi
Hozumi Motohashi Tohoku University
David J. States
David J. States University of Michigan–Ann Arbor
Alfred O. Hero
Alfred O. Hero University of Michigan–Ann Arbor
Jerry B. Dodgson
Jerry B. Dodgson Michigan State University
H. Leighton Grimes
H. Leighton Grimes Cincinnati Children's Hospital Medical Center
Akiyoshi Fukamizu
Akiyoshi Fukamizu University of Tsukuba
Ivan Maillard
Ivan Maillard University of Pennsylvania
Frank Grosveld
Frank Grosveld Erasmus University Rotterdam

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