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Biology and Biochemistry

D-Index
83
Citations
26192
World Ranking
3478
National Ranking
212

Overview

Shigeo Ohta is affiliated with Juntendo University in Japan and has a significant publication record in the field of medicine, particularly focusing on hydrogen's biological and therapeutic effects. Their research spans several subfields, including surgery, physiology, materials chemistry, developmental neuroscience, and epidemiology.

Ohta's work explores diverse topics, with a primary concentration on hydrogen's biological and therapeutic effects. Additional main areas of investigation include biochemical effects in animals, adipose tissue and metabolism, hydrogen storage and materials, anesthesia and neurotoxicity research, adipokines, inflammation and metabolic diseases, as well as the neuroscience of respiration and sleep.

Frequent collaborators in Ohta's research include Naomi Kamimura, Hirohisa Ono, Yoji Nishijima, Alexander M. Wolf, and Ikuroh Ohsawa.

Ohta has contributed to multiple scientific journals, with the most frequent publication venues being:

  • Current Pharmaceutical Design
  • Scientific Reports
  • Aging Pathobiology and Therapeutics
  • Pharmaceuticals
  • Molecular Metabolism

Some recent papers authored by Ohta and colleagues include:

  • "Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism," 2022, Scientific Reports
  • "Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions," 2020, Current Pharmaceutical Design
  • "Molecular hydrogen may activate the transcription factor Nrf2 to alleviate oxidative stress through the hydrogen-targeted porphyrin," 2023, Aging Pathobiology and Therapeutics

In these publications, Ohta investigates molecular hydrogen's pathways and mechanisms related to oxidative stress, signaling pathways, and therapeutic implications. Their research integrates insights from physiology and materials chemistry to explore the biochemical pathways influenced by hydrogen at a molecular level.

Ohta's research interests include the study of adipose tissue and metabolism, reflected in their contributions on related biochemical and metabolic processes. The work also intersects with clinical topics such as anesthesia and neurotoxicity, emphasizing Ohta's multidisciplinary approach in medical research.

Best Publications

  • Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

    Ikuroh Ohsawa;Masahiro Ishikawa;Kumiko Takahashi;Megumi Watanabe

  • Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

    Yoshikuni Mizuno;Shigeo Ohta;Masashi Tanaka;Shinzaburo Takamiya

  • Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

    Jun-Ichi Hayashi;Shigeo Ohta;Aiko Kikuchi;Masakazu Takemitsu

  • Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan

    Masashi Tanaka;Vicente M. Cabrera;Ana M. González;José M. Larruga

  • Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.

    Kentaro Hayashida;Motoaki Sano;Motoaki Sano;Ikuroh Ohsawa;Ken Shinmura

  • Free anterolateral thigh flaps for reconstruction of head and neck defects.

    Isao Koshima;Hiroshi Fukuda;Hidekazu Yamamoto;Takahiko Moriguchi

  • Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.

    Kei ichi Fukuda;Sadamitsu Asoh;Masahiro Ishikawa;Yasuhiro Yamamoto

  • Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

    Shigeo Ohta

  • FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

    Naonobu Nishino;Yoshikazu Tamori;Sanshiro Tateya;Takayuki Kawaguchi

  • A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes).

    Yoko Kobayashi;Mariko Y. Momoi;Kaoru Tominaga;Takashi Momoi

  • The gene for Machado–Joseph disease maps to human chromosome 14q

    Y Takiyama;M Nishizawa;H Tanaka;S Kawashima

  • Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils.

    Yuji Yamaguchi;Toshio Suda;Shigeo Ohta;Kaoru Tominaga

  • The gluteal perforator-based flap for repair of sacral pressure sores

    Isao Koshima;Takahiko Moriguchi;Shugo Soeda;Shinsaku Kawata

  • Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.

    Takehiro Yasukawa;Takehiro Yasukawa;Tsutomu Suzuki;Takeo Suzuki;Takuya Ueda

  • Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.

    Shigeo Ohta

  • Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

    Kazufumi Nagata;Naomi Nakashima-Kamimura;Toshio Mikami;Ikuroh Ohsawa

  • Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from Apoptosis

    Yujiro Shidara;Kumi Yamagata;Takashi Kanamori;Kazutoshi Nakano

  • Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease.

    Yohei Kirino;Takehiro Yasukawa;Takehiro Yasukawa;Shigeo Ohta;Shigeo Akira

  • Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model.

    Jianmei Cai;Zhimin Kang;Wen Wu Liu;Xu Luo

  • Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease

    Takehiro Yasukawa;Takehiro Yasukawa;Tsutomu Suzuki;Norie Ishii;Shigeo Ohta

Frequent Co-Authors

Yasuo Kagawa
Yasuo Kagawa Kagawa Nutrition University
Keiichi Fukuda
Keiichi Fukuda Keio University
Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo
Kimitsuna Watanabe
Kimitsuna Watanabe National Institute of Advanced Industrial Science and Technology
Jun-Ichi Hayashi
Jun-Ichi Hayashi University of Tsukuba
Naohiro Inohara
Naohiro Inohara University of Michigan–Ann Arbor
Makoto Suematsu
Makoto Suematsu Keio University
Masashi Tanaka
Masashi Tanaka Juntendo University
Nobutaka Hattori
Nobutaka Hattori Juntendo University
Yu-ichi Goto
Yu-ichi Goto University of Tsukuba

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