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D-Index
69
Citations
21880
World Ranking
2326
National Ranking
88

Overview

Yu-ichi Goto is affiliated with the University of Tsukuba in Japan and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research focuses primarily on genetics and neurodevelopmental disorders, genomic variations and chromosomal abnormalities, genomics and rare diseases, mitochondrial function and pathology, RNA modifications and cancer, metabolism and genetic disorders, and cancer genomics and diagnostics.

Recent notable publications by Yu-ichi Goto include:

  • Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability, 2021, Science Advances
  • Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder, 2022, Biological Psychiatry
  • Six years' accomplishment of the Initiative on Rare and Undiagnosed Diseases: nationwide project in Japan to discover causes, mechanisms, and cures, 2022, Journal of Human Genetics
  • Simultaneous measurement of the size and methylation of chromosome 4qA-D4Z4 repeats in facioscapulohumeral muscular dystrophy by long-read sequencing, 2022, Journal of Translational Medicine
  • Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1-Related Microglial Activation in Neonatal Hypoxic-Ischemic Encephalopathy, 2021, American Journal Of Pathology

The scientist frequently collaborates with a group of co-authors, with notable frequent collaborators including Aritoshi Iida, Ichizo Nishino, Kotaro Hattori, Katsushi Tokunaga, and Ken Inoue. These collaborations support a diverse range of studies in related biomedical fields.

Yu-ichi's work has been published in several recurring scientific venues, indicative of their research focus and standing in the academic community. These venues include:

  • Journal of Human Genetics
  • Anticancer Research
  • Brain and Development
  • arXiv (Cornell University)
  • Biological Psychiatry

The main fields of study covered in Yu-ichi Goto's research are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields investigated include:

  • Genetics
  • Molecular Biology
  • Neurology
  • Immunology
  • Cancer Research

Best Publications

  • A mutation in the tRNA Leu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

    Yu-Ichi Goto;Ikuya Nonaka;Satoshi Horai

  • Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

    Naotada Ishihara;Masatoshi Nomura;Akihiro Jofuku;Hiroki Kato

  • Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.

    Yuka Kimura;Yu-Ichi Goto;Hideo Kimura

  • A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA

    T Kadowaki;H Kadowaki;Y Mori;K Tobe

  • Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

    Jun-Ichi Hayashi;Shigeo Ohta;Aiko Kikuchi;Masakazu Takemitsu

  • Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

    Kazuto Nakada;Kimiko Inoue;Kimiko Inoue;Tomoko Ono;Kotoyo Isobe

  • Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

    Kimiko Inoue;Kazuto Nakada;Atsuo Ogura;Kotoyo Isobe

  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes (MELAS) A correlative study of the clinical features and mitochondrial DNA mutation

    Y. Goto;S. Horai;T. Matsuoka;Y. Koga

  • Mutations in the integrin alpha7 gene cause congenital myopathy.

    Yukiko K. Hayashi;Fan-Li Chou;Eva Engvall;Megumu Ogawa

  • A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).

    Yu-ichi Goto;Ikuya Nonaka;Satoshi Horai

  • Angiotensinogen-deficient mice with hypotension.

    K. Tanimoto;F. Sugiyama;Y. Goto;J. Ishida

  • Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

    Yuichi Matsushima;Yu Ichi Goto;Laurie S. Kaguni

  • Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.

    Hitomi Hasegawa;Taro Matsuoka;Yu-ichi Goto;Ikuya Nonaka

  • Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.

    Hiromi Fukushima-Uesaka;Yoshiro Saito;Hidemi Watanabe;Kisho Shiseki

  • Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

    Itaru Kushima;Branko Aleksic;Masahiro Nakatochi;Teppei Shimamura

  • Reduction of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase activity and sialylation in distal myopathy with rimmed vacuoles.

    Satoru Noguchi;Yoko Keira;Kumiko Murayama;Megumu Ogawa

  • Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease

    Yohei Kirino;Yu-ichi Goto;Yolanda Campos;Joaquin Arenas

  • Human mitochondria and mitochondrial genome function as a single dynamic cellular unit

    J.-I. Hayashi;M. Takemitsu;Y.-I. Goto;I. Nonaka

  • Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca2+ channels

    Yukari Endo;Satoru Noguchi;Yuji Hara;Yukiko K. Hayashi

  • Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations

    Emiko Noguchi;Hiromi Sakamoto;Tomomitsu Hirota;Kaori Ochiai

Frequent Co-Authors

Ikuya Nonaka
Ikuya Nonaka Tokyo Medical University
Ichizo Nishino
Ichizo Nishino Tokyo Medical University
Satoshi Horai
Satoshi Horai The Graduate University for Advanced Studies, SOKENDAI
Hideo Kimura
Hideo Kimura University of Tokyo
Kenji Sugai
Kenji Sugai Tohoku University
Kotaro Hattori
Kotaro Hattori National Center of Neurology and Psychiatry
Jun-ichi Sawada
Jun-ichi Sawada University of Shizuoka
Yoshiro Saito
Yoshiro Saito Tohoku University
Satoru Noguchi
Satoru Noguchi Tokyo Medical University
Jun-Ichi Hayashi
Jun-Ichi Hayashi University of Tsukuba

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