Jun-ichi Sawada

Overview

Best Publications

• The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

  Regina Groisman;Jolanta Polanowska;Isao Kuraoka;Jun-ichi Sawada

  899
  Citations

• Coordinated histone modifications mediated by a CtBP co-repressor complex

  Yujiang Shi;Jun-ichi Sawada;Guangchao Sui;El Bachir Affar

  856
  Citations

• HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.

  Nahoko Kaniwa;Yoshiro Saito;Michiko Aihara;Kayoko Matsunaga

  493
  Citations

• Functional Analysis of SNPs Variants of BCRP/ABCG2

  Chihiro Kondo;Hiroshi Suzuki;Masaya Itoda;Shogo Ozawa

  370
  Citations

• Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.

  Hironobu Minami;Kimie Sai;Mayumi Saeki;Yoshiro Saito

  333
  Citations

• UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.

  Kimie Sai;Mayumi Saeki;Yoshiro Saito;Shogo Ozawa

  291
  Citations

• Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.

  Hiromi Fukushima-Uesaka;Yoshiro Saito;Hidemi Watanabe;Kisho Shiseki

  245
  Citations

• Comparative Study of in Vitro Digestibility of Food Proteins and Effect of Preheating on the Digestion

  Kayoko Takagi;Reiko Teshima;Haruyo Okunuki;Jun-ichi Sawada

  239
  Citations

• Pharmacokinetics of Gemcitabine in Japanese Cancer Patients: The Impact of a Cytidine Deaminase Polymorphism

  Emiko Sugiyama;Nahoko Kaniwa;Su-Ryang Kim;Ruri Kikura-Hanajiri

  224
  Citations

• Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African-American.

  Nahoko Kaniwa;Kouichi Kurose;Hideto Jinno;Toshiko Tanaka-Kagawa

  212
  Citations

• Ethnic Differences in Genetic Polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1

  Shogo Ozawa;Akiko Soyama;Mayumi Saeki;Hiromi Fukushima-Uesaka

  206
  Citations

• Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin

  N Hanioka;S Ozawa;H Jinno;M Ando

  187
  Citations

• Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

  Kimie Sai;Nahoko Kaniwa;Masaya Itoda;Yoshiro Saito

  173
  Citations

• Dietary unripe apple polyphenol inhibits the development of food allergies in murine models.

  Hiroshi Akiyama;Yuji Sato;Takahiro Watanabe;Megumi H. Nagaoka

  156
  Citations

• Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.

  Masakazu Hirouchi;Hiroshi Suzuki;Masaya Itoda;Shogo Ozawa

  155
  Citations

• Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.

  Akiko Soyama;Yoshiro Saito;Nobumitsu Hanioka;Norie Murayama

  144
  Citations

• Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals : an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28

  Masaya Itoda;Yoshiro Saito;Akiko Soyama;Mayumi Saeki

  133
  Citations

• Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.

  Satoru Koyano;Kouichi Kurose;Yoshiro Saito;Shogo Ozawa

  132
  Citations

• Severe Drug Toxicity Associated with a Single-Nucleotide Polymorphism of the Cytidine Deaminase Gene in a Japanese Cancer Patient Treated with Gemcitabine plus Cisplatin

  Kan Yonemori;Hideki Ueno;Takuji Okusaka;Noboru Yamamoto

  124
  Citations

• Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes

  Norie Murayama;Akiko Soyama;Yoshiro Saito;Yukiko Nakajima

  123
  Citations