What is he best known for?
The fields of study he is best known for:
- Cancer
- Internal medicine
- Gene
Pharmacology, Pharmacokinetics, Paclitaxel, Pharmacogenetics and Chemotherapy are his primary areas of study.
His Pharmacology study combines topics from a wide range of disciplines, such as CYP3A4, Organic cation transport proteins, Toxicity and Docetaxel.
His Docetaxel study deals with Taxane intersecting with Biological activity and Adverse effect.
His work deals with themes such as Oral administration, Irinotecan, Bioavailability and Drug, which intersect with Pharmacokinetics.
His Paclitaxel research integrates issues from Dosage form, Neurotoxicity, Distribution and Pharmaceutical formulation.
The various areas that Alex Sparreboom examines in his Pharmacogenetics study include Pharmacogenomics, Multidrug resistance-associated protein 2 and Allele frequency.
His most cited work include:
- Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. (1216 citations)
- Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine (770 citations)
- Clinical pharmacokinetics and metabolism of irinotecan (CPT-11) (588 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Pharmacology, Pharmacokinetics, Paclitaxel, Internal medicine and Chemotherapy.
His Pharmacology research incorporates themes from Irinotecan, Toxicity and Docetaxel.
His study looks at the relationship between Pharmacokinetics and fields such as Cancer, as well as how they intersect with chemical problems.
His studies deal with areas such as Taxane, Chromatography and Distribution as well as Paclitaxel.
His study in Internal medicine is interdisciplinary in nature, drawing from both Gastroenterology, Endocrinology and Oncology.
Alex Sparreboom works on Chemotherapy which deals in particular with Cisplatin.
He most often published in these fields:
- Pharmacology (76.47%)
- Pharmacokinetics (54.99%)
- Paclitaxel (18.93%)
What were the highlights of his more recent work (between 2015-2021)?
- Pharmacology (76.47%)
- Transporter (9.46%)
- Cancer research (8.18%)
In recent papers he was focusing on the following fields of study:
Alex Sparreboom mostly deals with Pharmacology, Transporter, Cancer research, Pharmacokinetics and Drug.
His Pharmacology research is multidisciplinary, relying on both Neurotoxicity, Tyrosine kinase, Nilotinib, Organic anion transporter 1 and Efflux.
His study on Transporter also encompasses disciplines like
- Sorafenib which connect with Liver cancer, HEK 293 cells and Carcinoma,
- Xenobiotic and related Hepatocyte, Multidrug resistance-associated protein 2, Endocrinology and Glucuronide.
His Cancer research research incorporates elements of Leukemia, Paclitaxel and In vivo.
His Pharmacokinetics study incorporates themes from Cancer, Area under the curve, Chromatography, Toxicity and Organic anion-transporting polypeptide.
His Drug research is multidisciplinary, incorporating elements of Drug transporter and Distribution.
Between 2015 and 2021, his most popular works were:
- A phosphotyrosine switch regulates organic cation transporters. (61 citations)
- Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors (33 citations)
- Loss of SLCO1B3 drives taxane resistance in prostate cancer (32 citations)
In his most recent research, the most cited papers focused on:
- Cancer
- Internal medicine
- Gene
Alex Sparreboom mainly investigates Pharmacology, Transporter, Cancer research, Efflux and Sorafenib.
His Pharmacology study incorporates themes from Tyrosine kinase, Nilotinib, Organic anion transporter 1, Tyrosine-kinase inhibitor and Drug resistance.
His Organic anion transporter 1 research focuses on subjects like Taxane, which are linked to Docetaxel.
His Cancer research research is multidisciplinary, incorporating perspectives in RNA, Immune system, Prodrug, Toxicity and Breast cancer.
His biological study spans a wide range of topics, including Endocrinology, Glucuronide, Xenobiotic and Hepatocyte.
Alex Sparreboom interconnects Cancer and Pharmacokinetics in the investigation of issues within Genetic model.
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