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Medicine

D-Index
108
Citations
37519
World Ranking
6059
National Ranking
3242

Overview

Alex Sparreboom is affiliated with The Ohio State University in the United States. Their research spans multiple fields, with a primary focus on Medicine and Biochemistry, Genetics and Molecular Biology. They have contributed extensively to subfields such as Oncology, Molecular Biology, Pharmacology, Genetics, and Hematology.

Their work touches on a variety of topics including Drug Transport and Resistance Mechanisms, Cancer Treatment and Pharmacology, Pharmacological Effects and Toxicity Studies, Pharmacogenetics and Drug Metabolism, Cancer Therapeutics and Mechanisms, Chronic Lymphocytic Leukemia Research, and HIV/AIDS Drug Development and Treatment.

Alex Sparreboom has published research in various scientific venues frequently. Notable publication venues include:

  • Journal of Pharmacology and Experimental Therapeutics
  • Journal of Chromatography B
  • The FASEB Journal
  • Journal of Clinical Oncology
  • Pharmaceutics

Recent papers authored or co-authored by Sparreboom cover a range of topics related to drug delivery, cancer therapy, and pharmacology. These include:

  • "Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy" (2020, Nature Communications)
  • "Membrane transporters in drug development and as determinants of precision medicine" (2024, Nature Reviews Drug Discovery)
  • "Appropriate Systemic Therapy Dosing for Obese Adult Patients With Cancer: ASCO Guideline Update" (2021, Journal of Clinical Oncology)
  • "Targeting OCT3 attenuates doxorubicin-induced cardiac injury" (2021, Proceedings of the National Academy of Sciences)
  • "Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice" (2020, Journal of Clinical Investigation)

Collaborations play an important role in their research endeavors. Frequent co-authors include:

  • Shuiying Hu
  • Sharyn D. Baker
  • Eric D. Eisenmann
  • Yan Jin
  • Kevin M. Huang

Best Publications

  • Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.

    Hans Gelderblom;Jaap Verweij;Kees Nooter;Alex Sparreboom

  • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

    A. Sparreboom;J. van Asperen;U. Mayer;A.H. Schinkel

  • Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)

    Ron H. J. Mathijssen;Robbert J. van Alphen;Jaap Verweij;Walter J. Loos

  • Pharmacological effects of formulation vehicles : implications for cancer chemotherapy.

    Albert J ten Tije;Jaap Verweij;Walter J Loos;Alex Sparreboom;Alex Sparreboom

  • Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline

    Jennifer J. Griggs;Pamela B. Mangu;Holly Anderson;Edward P. Balaban

  • Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents

    Alex Sparreboom;Michael C. Cox;Milin R. Acharya;William D. Figg

  • Comparative Preclinical and Clinical Pharmacokinetics of a Cremophor-Free, Nanoparticle Albumin-Bound Paclitaxel (ABI-007) and Paclitaxel Formulated in Cremophor (Taxol)

    Alex Sparreboom;Charity D. Scripture;Vuong Trieu;Paul J. Williams

  • Effects of St. John's Wort on Irinotecan Metabolism

    Ron H. J. Mathijssen;Jaap Verweij;Peter de Bruijn;Walter J. Loos

  • Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma

    Qin C. Ryan;Donna Headlee;Milin Acharya;Alex Sparreboom

  • Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.

    Kelly K. Filipski;Kelly K. Filipski;Ron H. Mathijssen;Torben S. Mikkelsen;Torben S. Mikkelsen;Alfred H. Schinkel

  • Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

    Lisa R. Treviño;Noriko Shimasaki;Wenjian Yang;John C. Panetta

  • Role of Formulation Vehicles in Taxane Pharmacology

    Lia van Zuylen;Jaap Verweij;Alex Sparreboom

  • Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

    Ivana Gojo;Anchalee Jiemjit;Jane B. Trepel;Alex Sparreboom

  • Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001

    Sharyn D. Baker;Jaap Verweij;Eric K. Rowinsky;Ross C. Donehower

  • Irinotecan Pathway Genotype Analysis to Predict Pharmacokinetics

    Ron H. J. Mathijssen;Sharon Marsh;Mats O. Karlsson;Rujia Xie

  • Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives.

    Charity D Scripture;William D Figg;Alex Sparreboom

  • Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

    Alex Sparreboom;Romano Danesi;Yuichi Ando;Juliana Chan

  • Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

    Alex Sparreboom;Hans Gelderblom;Sharon Marsh;Ranjeet Ahluwalia

  • Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review

    Milin R. Acharya;Alex Sparreboom;Jürgen Venitz;William D. Figg

  • Pharmacogenetics of ABCG2 and Adverse Reactions to Gefitinib

    George Cusatis;Vanesa Gregorc;Jing Li;Anna Spreafico

Frequent Co-Authors

Jaap Verweij
Jaap Verweij Erasmus University Rotterdam
William D. Figg
William D. Figg National Institutes of Health
Sharyn D. Baker
Sharyn D. Baker The Ohio State University
Ron H.J. Mathijssen
Ron H.J. Mathijssen Erasmus University Rotterdam
Hans Gelderblom
Hans Gelderblom Leiden University Medical Center
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Ron H.N. van Schaik
Ron H.N. van Schaik Erasmus University Rotterdam
Eberhard Schlatter
Eberhard Schlatter University of Münster
Susan E. Bates
Susan E. Bates Columbia University
Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital

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