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Biology and Biochemistry

D-Index
63
Citations
15044
World Ranking
10163
National Ranking
4442

Overview

Federico Innocenti is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a focus on Oncology, Molecular Biology, Cancer Research, Pathology and Forensic Medicine, and Pulmonary and Respiratory Medicine.

Their scholarly contributions emphasize key topics including Colorectal Cancer Treatments and Studies, Cancer Genomics and Diagnostics, Genetic factors in colorectal cancer, Cancer therapeutics and mechanisms, Epigenetics and DNA Methylation, Lung Cancer Research Studies, and Gastric Cancer Management and Outcomes.

Significant recent publications illustrate the scope of Federico Innocenti's work. These include:

  • ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper (2020), Nature Reviews Clinical Oncology
  • Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs (2022), Cancer Science
  • Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial (2020), UNC Libraries
  • All You Need to Know About DPYD Genetic Testing for Patients Treated With Fluorouracil and Capecitabine: A Practitioner-Friendly Guide (2020), JCO Oncology Practice
  • Genetic effects on liver chromatin accessibility identify disease regulatory variants (2021), The American Journal of Human Genetics

The scientist frequently collaborates with the following coauthors:

  • Alan P. Venook
  • Heinz-Josef Lenz
  • Fang-Shu Ou
  • Amy S. Etheridge
  • Richard M. Goldberg

Their research has been published extensively in various venues, with a particular concentration in:

  • UNC Libraries
  • Journal of Clinical Oncology
  • The Pharmacogenomics Journal
  • Cancer Research
  • JCO Oncology Practice

Best Publications

  • Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

    Adrian Ally;Miruna Balasundaram;Rebecca Carlsen;Eric Chuah

  • Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.

    Federico Innocenti;Samir D. Undevia;Lalitha Iyer;Pei Xian Chen

  • Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)

    Hedy Lee Kindler;Donna Niedzwiecki;Donna Hollis;Susan Sutherland

  • Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial

    Alan P. Venook;Donna Niedzwiecki;Heinz Josef Lenz;Federico Innocenti

  • CALGB/SWOG 80405: Phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC).

    Alan P. Venook;Donna Niedzwiecki;Heinz-Josef Lenz;Federico Innocenti

  • Impact of primary (1{o}) tumor location on overall survival (OS) and progression-free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC): Analysis of CALGB/SWOG 80405 (Alliance).

    Alan P. Venook;Donna Niedzwiecki;Federico Innocenti;Briant Fruth

  • ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.

    Arvind Dasari;Van K. Morris;Carmen J. Allegra;Chloe Atreya

  • Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

    Brian M. Wolpin;Cosmeri Rizzato;Peter Kraft;Charles Kooperberg

  • Predictive Role of the UGT1A1, UGT1A7, and UGT1A9 Genetic Variants and Their Haplotypes on the Outcome of Metastatic Colorectal Cancer Patients Treated With Fluorouracil, Leucovorin, and Irinotecan

    Erika Cecchin;Federico Innocenti;Mario D'Andrea;Giuseppe Corona

  • Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and Pharmacokinetics

    Federico Innocenti;Deanna L. Kroetz;Erin Schuetz;M. Eileen Dolan

  • Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome

    Federico Innocenti;Fang Shu Ou;Xueping Qu;Tyler J. Zemla

  • Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

    Federico Innocenti;Gregory M. Cooper;Ian B. Stanaway;Eric R. Gamazon

  • Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance).

    Heinz Josef Lenz;Fang Shu Ou;Alan P. Venook;Howard S. Hochster

  • Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer

    Soundararajan Krishnaswamy;Rajani Kanteti;Jonathan S. Duke-Cohan;Sivakumar Loganathan

  • A Functional Common Polymorphism in a Sp1 Recognition Site of the Epidermal Growth Factor Receptor Gene Promoter

    Wanqing Liu;Federico Innocenti;Michael H. Wu;Apurva A. Desai

  • Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

    Kaixin Zhou;Sook Wah Yee;Eric L Seiser;Nienke van Leeuwen

  • Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.

    Giuseppe Toffoli;Antonio Russo;Federico Innocenti;Giuseppe Corona

  • A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine.

    Michael B. Sawyer;Michael B. Sawyer;Federico Innocenti;Federico Innocenti;Soma Das;Soma Das;Cheng Cheng;Cheng Cheng

  • Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.

    Federico Innocenti;Carrie Grimsley;Soma Das;Jacqueline Ramírez

  • Genotype-Driven Phase I Study of Irinotecan Administered in Combination With Fluorouracil/Leucovorin in Patients With Metastatic Colorectal Cancer

    Giuseppe Toffoli;Erika Cecchin;Giampiero Gasparini;Mario D'andrea

Frequent Co-Authors

Mark J. Ratain
Mark J. Ratain University of Chicago
Alan P. Venook
Alan P. Venook University of California, San Francisco
Donna Niedzwiecki
Donna Niedzwiecki Duke University
Heinz-Josef Lenz
Heinz-Josef Lenz University of Southern California
Charles D. Blanke
Charles D. Blanke Oregon Health & Science University
Richard M. Goldberg
Richard M. Goldberg West Virginia University
Robert J. Mayer
Robert J. Mayer Dana-Farber Cancer Institute
Monica M. Bertagnolli
Monica M. Bertagnolli Brigham and Women's Hospital
Jeffrey A. Meyerhardt
Jeffrey A. Meyerhardt Harvard University
Soma Das
Soma Das University of Chicago

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