Hiroshi Handa is affiliated with Tokyo Medical University in Japan. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong emphasis on molecular biology, hematology, and neurology. Their work also intersects related subfields such as genetics and immunology.
Handa's main research topics include multiple myeloma research and treatments, protein degradation and inhibitors, amyotrophic lateral sclerosis (ALS) research, ubiquitin and proteasome pathways, neurogenetic and muscular disorders research, histone deacetylase inhibitors research, and platelet disorders and treatments.
Frequent collaborators in Handa's research activities include Takumi Ito, Kazuhide Asakawa, Koichi Kawakami, Junichi Yamamoto, and Yuki Yamaguchi. Their scholarly output features publications in several recurrent venues, with multiple articles published in Clinical Lymphoma Myeloma & Leukemia, Nature Communications, Cancers, Scientific Reports, and Communications Biology.
Among recent notable publications are:
Handa's research contributions cover molecular mechanisms related to thalidomide and its derivatives, their impact on protein degradation pathways, and neurological disease mechanisms, particularly ALS. The scientist's work also includes investigations on the substrates targeted by cereblon (CRBN), which plays a role in the therapeutic effects of immunomodulatory drugs used in multiple myeloma.
Takumi Ito;Hideki Ando;Takayuki Suzuki;Toshihiko Ogura
Yuki Yamaguchi;Toshiyuki Takagi;Tadashi Wada;Keiichi Yano
K Araki-Sasaki;Y Ohashi;T Sasabe;K Hayashi
Tadashi Wada;Toshiyuki Takagi;Yuki Yamaguchi;Anwarul Ferdous
A Lopez-Girona;D Mendy;T Ito;K Miller
Ken-Ichirou Morohashi;Shin Ichiro Honda;Yukio Inomata;Hiroshi Handa
Yasuaki Kabe;Kozue Ando;Satoshi Hirao;Makoto Yoshida
Anita K Gandhi;Jian Kang;Courtney G Havens;Thomas Conklin
Grant A. Hartzog;Tadashi Wada;Hiroshi Handa;Fred Winston
Tadashi Wada;Toshiyuki Takagi;Yuki Yamaguchi;Daisuke Watanabe
Mary E. Matyskiela;Gang Lu;Takumi Ito;Barbra Pagarigan
Tomoko Yamada;Yuki Yamaguchi;Yuki Yamaguchi;Naoto Inukai;Sachiko Okamoto
Philip P Chamberlain;Antonia Lopez-Girona;Karen Miller;Gilles Carmel
Kohsuke Kataoka;Song-iee Han;Setsuko Shioda;Momoki Hirai
Chwen Huey Wu;Yuki Yamaguchi;Lawrence R. Benjamin;Maria Horvat-Gordon
Noriyuki Azuma;Yuki Yamaguchi;Hiroshi Handa;Keiko Tadokoro
Noriaki Shimizu;Kotaro Sugimoto;Jianwei Tang;Takeyuki Nishi
Yuki Yamaguchi;Naoto Inukai;Takashi Narita;Tadashi Wada
Takashi Narita;Yuki Yamaguchi;Keiichi Yano;Seiji Sugimoto
Gang Wang;Michael A. Balamotis;Jennitte L. Stevens;Yuki Yamaguchi
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