World's Best Scientists 2026 revealed!
Phillip A. Sharp

Phillip A. Sharp

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Best Scientists
2025
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Molecular Biology
USA
2026

D-Index & Metrics

Best Scientists

D-Index
200
Citations
164518
World Ranking
296
National Ranking
195

Molecular Biology

D-Index
200
Citations
165138
World Ranking
20
National Ranking
13

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2004 - US President's National Medal of Science "For his contributions to understanding the biochemical pathway of RNA interference phenomena and for his use of RNA interference techniques to perform genetic analyses in mammalian cells.", Presented by President George W. Bush in a White House East Room ceremony on February 13, 2006.
  • 2002 - Fellow of the Royal Society of Edinburgh
  • 1993 - Nobel Prize for their discoveries of split genes
  • 1991 - Member of the National Academy of Medicine (NAM)
  • 1988 - Louisa Gross Horwitz Prize, Columbia University
  • 1988 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 1987 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1986 - Alfred P. Sloan Jr. Prize, General Motors Cancer Research Foundation
  • 1986 - Canada Gairdner International Award
  • 1983 - Fellow of the American Academy of Arts and Sciences
  • 1983 - Member of the National Academy of Sciences

Overview

Phillip A. Sharp is affiliated with MIT in the United States and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology. Their research spans oncology, immunology, genetics, and cancer research.

Their recent publications include:

  • RNA-Mediated Feedback Control of Transcriptional Condensates, 2020, Cell
  • Partitioning of cancer therapeutics in nuclear condensates, 2020, Science
  • RNA in formation and regulation of transcriptional condensates, 2021, RNA
  • Single-cell nascent RNA sequencing unveils coordinated global transcription, 2024, Nature
  • Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons, 2020, Molecular Cell

Frequent co-authors collaborating with Sharp include:

  • Dig Bijay Mahat
  • Vikash P. Chauhan
  • Richard A. Young
  • Sean K. Waterton
  • Arundeep Singh

Sharp's work has been published largely in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science
  • Nature
  • Proceedings of the National Academy of Sciences
  • Molecular Cell

Their primary fields and subfields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Oncology
  • Immunology
  • Genetics
  • Cancer Research

Main topics of Sharp's research cover:

  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • CRISPR and Genetic Engineering
  • Pluripotent Stem Cells Research
  • Genomics and Chromatin Dynamics
  • Single-cell and spatial transcriptomics
  • RNA modifications and cancer

The scientist has received several awards, including:

  • Nobel Prize in 1993 for their discoveries of split genes
  • US President's National Medal of Science in 2004, awarded for contributions to understanding RNA interference and its use in genetic analyses in mammalian cells
  • Fellow of the Royal Society of Edinburgh in 2002
  • Member of the National Academy of Medicine in 1991
  • Albert Lasker Award for Basic Medical Research in 1988
  • Louisa Gross Horwitz Prize in 1988
  • Fellow of the American Association for the Advancement of Science in 1987
  • Canada Gairdner International Award in 1986
  • Alfred P. Sloan Jr. Prize in 1986
  • Member of the National Academy of Sciences in 1983
  • Fellow of the American Academy of Arts and Sciences in 1983

Best Publications

  • Histone H3K27ac separates active from poised enhancers and predicts developmental state

    Menno P. Creyghton;Albert W. Cheng;G. Grant Welstead;Tristan G. Kooistra

  • RNAi: Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals

    Phillip D. Zamore;Thomas Tuschl;Phillip A. Sharp;David P. Bartel

  • Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

    Arnold J. Berk;Phillip A. Sharp

  • In vivo genome editing using Staphylococcus aureus Cas9

    F. Ann Ran;Le Cong;Winston X. Yan;David A. Scott

  • Coactivator condensation at super-enhancers links phase separation and gene control

    Benjamin R. Sabari;Alessandra Dall’Agnese;Ann Boija;Isaac A. Klein;Isaac A. Klein

  • MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

    Margaret S Ebert;Joel R Neilson;Phillip A Sharp

  • Gene silencing in mammals by small interfering RNAs

    Michael T. McManus;Phillip A. Sharp

  • CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

    Randall J. Platt;Sidi Chen;Yang Zhou;Michael J. Yim

  • Specificity of microRNA target selection in translational repression

    John G. Doench;Phillip A. Sharp

  • Roles for MicroRNAs in Conferring Robustness to Biological Processes

    Margaret S. Ebert;Phillip A. Sharp

  • Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

    Andrea Ventura;Amanda G. Young;Monte M. Winslow;Laura Lintault

  • Lentivirus-delivered stable gene silencing by RNAi in primary cells.

    Sheila A. Stewart;Derek M. Dykxhoorn;Deborah Palliser;Hana Mizuno

  • Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis

    Phillip A. Sharp;Bill Sugden;Joe Sambrook

  • siRNAs can function as miRNAs

    John G. Doench;Christian P. Petersen;Phillip A. Sharp

  • Killing the messenger: short RNAs that silence gene expression

    Derek M. Dykxhoorn;Carl D. Novina;Phillip A. Sharp;Phillip A. Sharp

  • A Phase Separation Model for Transcriptional Control.

    Denes Hnisz;Krishna Shrinivas;Richard A. Young;Arup K. Chakraborty

  • Connecting microrna genes to the core transcriptional regulatory circuitry of embryonic stem cells

    Rudolph Jaenisch;Richard A. Young;Alexander Marson;Stuart Levine

  • Spliced segments at the 5' terminus of adenovirus 2 late mRNA

    Susan M. Berget;Claire Moore;Phillip A. Sharp

  • Targeted mRNA degradation by double-stranded RNA in vitro

    Thomas Tuschl;Phillip D. Zamore;Ruth Lehmann;David P. Bartel

  • Molecular biology. RNA interference

    P A Sharp;P D Zamore

Frequent Co-Authors

Thomas Tuschl
Thomas Tuschl Rockefeller University
Phillip D. Zamore
Phillip D. Zamore University of Massachusetts Chan Medical School
Joseph Sambrook
Joseph Sambrook The University of Texas Southwestern Medical Center

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