What is he best known for?
The fields of study he is best known for:
His main research concerns Molecular biology, Genetics, RNA, Gene and Cell biology.
His studies deal with areas such as DNA, Endonuclease, RNA polymerase II and Transcription factor as well as Molecular biology.
Phillip A. Sharp works mostly in the field of Genetics, limiting it down to topics relating to Computational biology and, in certain cases, Biological evolution.
His RNA research is multidisciplinary, relying on both Messenger RNA and splice.
His Cell biology research incorporates elements of Cell, Cellular differentiation, Transfection, Argonaute and Protein biosynthesis.
His RNA splicing research is multidisciplinary, incorporating elements of Intron and Small nuclear RNA.
His most cited work include:
- RNAi: Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals (2555 citations)
- Histone H3K27ac separates active from poised enhancers and predicts developmental state (2488 citations)
- Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids (1746 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Molecular biology, Cell biology, Gene, Genetics and RNA.
His study in Molecular biology is interdisciplinary in nature, drawing from both DNA, Messenger RNA, RNA splicing, RNA polymerase II and Transcription.
His Transcription research is multidisciplinary, incorporating perspectives in Promoter and Transcription factor.
His Cell biology study integrates concerns from other disciplines, such as microRNA, Argonaute and Binding site.
Genetics is frequently linked to Computational biology in his study.
His RNA study improves the overall literature in Biochemistry.
He most often published in these fields:
- Molecular biology (38.69%)
- Cell biology (24.75%)
- Gene (19.77%)
What were the highlights of his more recent work (between 2011-2021)?
- Genetics (19.77%)
- Cell biology (24.75%)
- Computational biology (7.40%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Genetics, Cell biology, Computational biology, Gene and microRNA.
His Cell biology study combines topics in areas such as Messenger RNA, Alternative splicing, Enhancer, Transcription and Regulation of gene expression.
His Computational biology research includes elements of Super-enhancer, Transcriptome, RNA-binding protein and RNA interference.
In his research, Metastasis and Cancer is intimately related to Cancer research, which falls under the overarching field of Gene.
The various areas that Phillip A. Sharp examines in his microRNA study include Gene expression, Gene regulatory network, Argonaute, Gene silencing and Dicer.
His study ties his expertise on Molecular biology together with the subject of RNA.
Between 2011 and 2021, his most popular works were:
- In vivo genome editing using Staphylococcus aureus Cas9 (1507 citations)
- Roles for MicroRNAs in Conferring Robustness to Biological Processes (1094 citations)
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling (1055 citations)
In his most recent research, the most cited papers focused on:
Phillip A. Sharp mainly investigates Genetics, Gene, Computational biology, Transcription and microRNA.
His research in Gene intersects with topics in Molecular biology and Cancer research.
His Molecular biology study incorporates themes from Cell culture, RNase P, Cell growth and Point mutation.
His Transcription research incorporates themes from Transcription factor, RNA polymerase II and Mediator, Cell biology.
He has researched Cell biology in several fields, including RNA Splicing Factors, RNA splicing, Alternative splicing and Exon.
His research integrates issues of Gene expression, Gene regulatory network, Gene expression profiling, Regulation of gene expression and Dicer in his study of microRNA.
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