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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
132
Citations
58574
World Ranking
177
National Ranking
112

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2006 - Fellow of the American Academy of Arts and Sciences

Overview

James L. Manley is affiliated with Columbia University in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a particular emphasis on Molecular Biology.

Their work spans a variety of subfields including:

  • Molecular Biology
  • Neurology
  • Genetics
  • Hematology
  • Immunology

Manley's research topics cover multiple areas related to RNA and disease, specifically:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Amyotrophic Lateral Sclerosis Research
  • Acute Myeloid Leukemia Research
  • Neurogenetic and Muscular Disorders Research
  • RNA regulation and disease

Their recent publications include:

  • "ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs" (2020), Genes & Development
  • "SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation" (2020), Autophagy
  • "SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes" (2021), Proceedings of the National Academy of Sciences
  • "Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation" (2020), Nature Communications
  • "Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains" (2020), Genome Research

Frequent coauthors who collaborate with Manley include:

  • Zhaoqi Liu
  • Jian Zhang
  • Pedro Bak-Gordon
  • Shuang Feng
  • Lizhi Liu

The scientist frequently publishes in the following venues:

  • Genes & Development
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • RNA Biology
  • Cell Reports

Among their recognitions, James L. Manley has been named a Fellow of the American Association for the Advancement of Science (AAAS) in 2008 and a Fellow of the American Academy of Arts and Sciences in 2006.

Best Publications

  • DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract

    James L. Manley;Andrew Fire;Amparo Cano;Phillip A. Sharp

  • Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

    Mo Chen;James L. Manley

  • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

    Charles J. David;Mo Chen;Marcela Assanah;Peter Canoll

  • Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

    Yingwu Xu;Xiao Tao;Baohe Shen;Tiffany Horng

  • Mechanism and regulation of mRNA polyadenylation

    Diana F. Colgan;James L. Manley

  • Alternative polyadenylation of mRNA precursors.

    Bin Tian;James L. Manley

  • SR proteins and splicing control.

    J L Manley;R Tacke

  • Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

    Charles J. David;James L. Manley

  • Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability

    Xialu Li;James L. Manley

  • Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

    Jhumku D. Kohtz;Sharon F. Jamison;Cindy L. Will;Ping Zuo;Ping Zuo

  • Mechanisms and Consequences of Alternative Polyadenylation

    Dafne Campigli Di Giammartino;Kensei Nishida;James L. Manley

  • The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

    Karen Colwill;Tony Pawson;Brenda Andrews;Jayendra Prasad

  • RNA polymerase II and the integration of nuclear events

    Yutaka Hirose;James L. Manley

  • The RNA polymerase II CTD coordinates transcription and RNA processing

    Jing-Ping Hsin;James L. Manley

  • A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

    Hui Ge;James L. Manley

  • A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy.

    Tsuyoshi Kashima;James L Manley

  • Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.

    Robert J. Sims;Scott Millhouse;Chi-Fu Chen;Brian A. Lewis

  • Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex

    Yongsheng Shi;Dafne Campigli Di Giammartino;Derek Taylor;Ali Sarkeshik

  • The Polyadenylation Factor CstF-64 Regulates Alternative Processing of IgM Heavy Chain Pre-mRNA during B Cell Differentiation

    Yoshio Takagaki;Rebecca L Seipelt;Martha L Peterson;James L Manley

  • Transcriptional repression of eukaryotic promoters.

    Michael Levine;James L. Manley

Frequent Co-Authors

Carol Prives
Carol Prives Columbia University
Bin Tian
Bin Tian The Wistar Institute
Liang Tong
Liang Tong Columbia University
Michael S. Levine
Michael S. Levine Princeton University
Raul Rabadan
Raul Rabadan Columbia University
John R. Yates
John R. Yates Scripps Research Institute
Richard Jove
Richard Jove Nova Southeastern University
Adrian R. Krainer
Adrian R. Krainer Cold Spring Harbor Laboratory
Matthew Meyerson
Matthew Meyerson Harvard University

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