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Malcolm L. Gefter

Malcolm L. Gefter

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
14907
World Ranking
7129
National Ranking
3271

Overview

Malcolm L. Gefter is affiliated with MIT in the United States and has contributed to research primarily in the field of Medicine. Their work spans several subfields including Oncology, Radiology, Nuclear Medicine and Imaging, Infectious Diseases, Rheumatology, and Immunology.

Their research topics focus on areas such as Monoclonal and Polyclonal Antibodies Research, CAR-T cell therapy research, SARS-CoV-2 and COVID-19 Research, HER2/EGFR in Cancer Research, Systemic Lupus Erythematosus Research, and T-cell and B-cell Immunology.

They have published recent papers in:

  • Topologically engineered antibodies and Fc-fusion proteins: a new class of multifunctional therapeutic candidates for SARS-CoV-2, cancer, and other disease (2022), bioRxiv (Cold Spring Harbor Laboratory)
  • Abstract 2730: Beyond antibodies and CAR-T: Topologically-engineered, super-dimeric antibody-like molecules with dual Fc domains for trispecific, bivalent targeting of CD19, CD20, and Fcgamma receptors (2024), Cancer Research
  • Topologically Engineered, Superdimeric α-CD19 x α-CD20 Bispecific Antibodies with Dual Enhanced Fc Domains: New Class of Natural Killer (NK)/Monocyte Engagers for Deep B Cell Depletion in Lupus Nephritis (2025), Journal of the American Society of Nephrology

Their frequent coauthors include:

  • Daniel J. Capon
  • Larisa Troitskaya
  • Marina E. Fomin
  • Ursula Edman
  • Brendon Frank

Malcolm L. Gefter has published work in several venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Journal of the American Society of Nephrology

Best Publications

  • DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract

    James L. Manley;Andrew Fire;Amparo Cano;Phillip A. Sharp

  • A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells.

    Malcolm L. Gefter;David H. Margulies;Matthew D. Scharff

  • Properties and Applications of Monoclonal Antibodies Directed against Determinants of the Thy-1 Locus

    Ann Marshak-Rothstein;Pamela Fink;Thomas Gridley;David H. Raulet

  • A DNA-unwinding protein isolated from Escherichia coli: its interaction with DNA and with DNA polymerases.

    Nolan Sigal;Hajo Delius;Thomas Kornberg;Malcolm L. Gefter

  • Analysis of DNA Polymerases II and III in Mutants of Escherichia coli Thermosensitive for DNA Synthesis

    Malcolm L. Gefter;Yukinori Hirota;Thomas Kornberg;James A. Wechsler

  • Immunological self, nonself discrimination.

    Jean-Gerard Guillet;Ming-Zong Lai;Thomas J. Briner;Soren Buus

  • Efficacy of a therapeutic cocaine vaccine in rodent models

    Barbara S. Fox;Kathleen M. Kantak;Melissa A. Edwards;Kerry M. Black

  • Role of γ-interferon in antibody-producing responses

    H. James Leibson;H. James Leibson;H. James Leibson;Malcolm Gefter;Malcolm Gefter;Malcolm Gefter;Albert Zlotnik;Albert Zlotnik;Albert Zlotnik;Philippa Marrack;Philippa Marrack;Philippa Marrack

  • Base substitution in an intervening sequence of a beta+-thalassemic human globin gene

    R. A. Spritz;P. Jagadeeswaran;Prabhakara V Choudary;P. A. Biro

  • Structure and in vitro transcription of human globin genes.

    Nicholas J. Proudfoot;Monica H. M. Shander;Jim L. Manley;Malcolm L. Gefter

  • Interaction of peptide antigens and class II major histocompatibility complex antigens.

    Jean-Gerrard Guillet;Ming-Zong Lai;Thomas J. Briner;John A. Smith

  • Somatic evolution of variable region structures during an immune response.

    Lawrence Wysocki;Tim Manser;Malcolm L. Gefter

  • A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

    Y Naparstek;J André-Schwartz;T Manser;L J Wysocki

  • Enzyme-catalyzed DNA unwinding: studies on Escherichia coli rep protein.

    Geoffrey T. Yarranton;Malcolm L. Gefter

  • Purification and DNA Synthesis in Cell-Free Extracts: Properties of DNA Polymerase II

    Thomas Kornberg;Malcolm L. Gefter

  • Evolution of antibody variable region structure during the immune response.

    Tim Manser;Lawrence J. Wysocki;Michael N. Margolies;Malcolm L. Gefter

  • Effect of IFN-γ on the immune response in vivo and on gene expression in vitro

    Masataka Nakamura;Tim Manser;Gregory D. N. Pearson;Michael J. Daley

  • Deoxyribonucleic Acid Synthesis in Cell-free Extracts IV. PURIFICATION AND CATALYTIC PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE III

    Thomas Kornberg;Malcolm L. Gefter

  • The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti‐arsonate idiotype in the strain A mouse

    Miriam Siekevitz;Shu Ying Huang;Malcolm L. Gefter

  • Properties of the Escherichia coli DNA-binding (unwinding) protein interaction with nucleolytic enzymes and DNA.

    Ian J. Molineux;Malcolm L. Gefter

Frequent Co-Authors

Mark A. Exley
Mark A. Exley Brigham and Women's Hospital
John A. Smith
John A. Smith University of Alabama at Birmingham
Ann Marshak-Rothstein
Ann Marshak-Rothstein University of Massachusetts Chan Medical School
Thomas B. Kornberg
Thomas B. Kornberg University of California, San Francisco
David L. Perkins
David L. Perkins University of New Mexico
Ming-Zong Lai
Ming-Zong Lai Academia Sinica
Jerard Hurwitz
Jerard Hurwitz Memorial Sloan Kettering Cancer Center
Ian J. Molineux
Ian J. Molineux The University of Texas at Austin
Gail E. Sonenshein
Gail E. Sonenshein Tufts University

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