Frank Miedema spends much of his time researching Immunology, Virology, T cell, CD8 and Cytotoxic T cell. As a member of one scientific family, Frank Miedema mostly works in the field of Immunology, focusing on Acquired immunodeficiency syndrome and, on occasion, Pathogenesis. His Virology research incorporates elements of Peripheral blood mononuclear cell and Asymptomatic.
The various areas that Frank Miedema examines in his T cell study include Molecular biology and Monoclonal antibody. His research investigates the connection between CD8 and topics such as Antiretroviral therapy that intersect with problems in Peripheral blood, Triple combination, Biphasic kinetics and Repopulation. His Cytotoxic T cell research focuses on subjects like Naive T cell, which are linked to Cell movement and Peripheral.
His main research concerns Immunology, Virology, T cell, Cytotoxic T cell and CD8. Immunology and Acquired immunodeficiency syndrome are commonly linked in his work. His Antigen research extends to the thematically linked field of Virology.
His T cell research includes themes of Molecular biology, Antibody, Monoclonal antibody and CD3. His Cytotoxic T cell research is multidisciplinary, incorporating perspectives in Human leukocyte antigen and Epstein–Barr virus. His work carried out in the field of Virus brings together such families of science as Phenotype and Peripheral blood mononuclear cell.
His primary areas of investigation include Immunology, Virology, CD8, T cell and Immune system. Frank Miedema regularly links together related areas like Cytotoxic T cell in his Immunology studies. His Virology research is multidisciplinary, incorporating elements of Acquired immunodeficiency syndrome and Antigen.
The concepts of his CD8 study are interwoven with issues in Receptor and Thymic Tissue. His study explores the link between T cell and topics such as Whole blood that cross with problems in Cell cycle, Lymphocyte, Apoptosis and Mycophenolate. His Immune system study incorporates themes from HUMAN THYMUS, Antibody and CD38.
Frank Miedema focuses on Immunology, Immune system, T cell, CD8 and Virology. His Immunology research incorporates themes from Cytotoxic T cell, Internal medicine, Cohort and Antiretroviral therapy. Frank Miedema has included themes like Viral rebound, Viral load, Viral replication and Acquired immunodeficiency syndrome in his Internal medicine study.
The study incorporates disciplines such as Hematopoietic stem cell transplantation, Stem cell, Severe combined immunodeficiency and Immunopathology in addition to T cell. The CD8 study combines topics in areas such as Acquired immune system, Interferon and Senescence. He combines subjects such as Perforin, Granzyme and Granzyme B with his study of Virology.
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Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population.
H Schuitemaker;M Koot;N A Kootstra;M W Dercksen.
Journal of Virology (1992)
Programmed death of T cells in HIV-1 infection
L Meyaard;SA Otto;RR Jonker;MJ Mijnster.
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
Stephen A. Migueles;Alisha C. Laborico;W. Lesley Shupert;M. Shirin Sabbaghian.
Nature Immunology (2002)
Prognostic Value of HIV-1 Syncytium-Inducing Phenotype for Rate of CD4+ Cell Depletion and Progression to AIDS
Maarten Koot;Ireneus P. M. Keet;Aster H. V. Vos;Ruud E. Y. de Goede.
Annals of Internal Medicine (1993)
Persistent immune activation in HIV-1 infection is associated with progression to AIDS.
Mette D. Hazenberg;Sigrid A. Otto;Birgit H. B. Van Benthem;Marijke Th. L. Roos.
Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule.
R A Fouchier;M Groenink;N A Kootstra;M Tersmette.
Journal of Virology (1992)
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.
M. Tersmette;R. A. Gruters;F. De Wolf;R. E. Y. De Goede.
Journal of Virology (1989)
Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality.
M. Tersmette;J. M. Lange;R. E. de Goede;F. de Wolf.
The Lancet (1989)
Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex.
M Tersmette;R E de Goede;B J Al;I N Winkel.
Journal of Virology (1988)
Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation
Nadine G. Pakker;Daan W. Notermans;Rob J. De Boer;Marijke T.L. Roos.
Nature Medicine (1998)
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