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Takanori Kanai

Takanori Kanai

D-Index & Metrics

Medicine

D-Index
90
Citations
30836
World Ranking
12177
National Ranking
358

Overview

Takanori Kanai is affiliated with Keio University in Japan and has published extensively in the field of Medicine, with a particular focus on Surgery, Pulmonary and Respiratory Medicine, Epidemiology, Oncology, and Genetics. Their research spans a wide range of medical topics, including inflammatory bowel disease, gastric cancer management and outcomes, liver disease diagnosis and treatment, Helicobacter pylori-related gastroenterology studies, COVID-19 clinical research studies, esophageal and gastrointestinal pathology, and pancreatic and hepatic oncology research.

Kanai's recent publications include the following papers:

  • The liver-brain-gut neural arc maintains the Treg cell niche in the gut, 2020, Nature
  • An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping, 2020, Cell
  • CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells, 2021, Nature Communications
  • An organoid-based organ-repurposing approach to treat short bowel syndrome, 2021, Nature
  • Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice, 2021, Microbiome

Their work has been published frequently in venues such as Gastroenterology, Gastrointestinal Endoscopy, Endoscopy, Digestive Endoscopy, and Scientific Reports. Kanai has collaborated with a number of frequent coauthors including Kaoru Takabayashi, Yohei Mikami, Tomohisa Sujino, Haruhiko Ogata, and Nobuhiro Nakamoto.

Main research topics covered in Kanai's publications include:

  • Inflammatory Bowel Disease
  • Gastric Cancer Management and Outcomes
  • Liver Disease Diagnosis and Treatment
  • Helicobacter pylori-related gastroenterology studies
  • COVID-19 Clinical Research Studies
  • Esophageal and GI Pathology
  • Pancreatic and Hepatic Oncology Research

The subfields of study Kanai has contributed to show a strong focus on clinical and translational medicine, especially in areas relating to surgery and respiratory medicine, with significant work in epidemiology and oncology as well. Their body of research covers a wide spectrum of gastrointestinal and liver-related conditions, linking molecular and clinical investigations.

Best Publications

  • Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

    Mami Matano;Shoichi Date;Mariko Shimokawa;Ai Takano

  • The gut microbiota and inflammatory bowel disease.

    Katsuyoshi Matsuoka;Takanori Kanai

  • A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.

    Masayuki Fujii;Mariko Shimokawa;Shoichi Date;Ai Takano

  • Visualization and targeting of LGR5 + human colon cancer stem cells

    Mariko Shimokawa;Yuki Ohta;Shingo Nishikori;Mami Matano

  • Evidence-based clinical practice guidelines for inflammatory bowel disease

    Katsuyoshi Matsuoka;Taku Kobayashi;Fumiaki Ueno;Toshiyuki Matsui

  • Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

    Takashi Seino;Shintaro Kawasaki;Mariko Shimokawa;Hiroki Tamagawa

  • Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract

    Ryuichi Okamoto;Tomoharu Yajima;Motomi Yamazaki;Takanori Kanai

  • Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

    Nobuhiro Nakamoto;Nobuo Sasaki;Nobuo Sasaki;Ryo Aoki;Ryo Aoki;Kentaro Miyamoto

  • A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice

    Atsushi Hayashi;Toshiro Sato;Nobuhiko Kamada;Yohei Mikami

  • CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells

    Shin Makita;Takanori Kanai;Shigeru Oshima;Koji Uraushihara

  • Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice.

    Kengo Tomita;Toshiaki Teratani;Takahiro Suzuki;Motonori Shimizu

  • MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis

    Akihiro Araki;Takanori Kanai;Takahiro Ishikura;Shin Makita

  • Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine

    Ce Tang;Ce Tang;Tomonori Kamiya;Yang Liu;Yang Liu;Motohiko Kadoki;Motohiko Kadoki

  • Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

    Tetsuro Takayama;Nobuhiko Kamada;Hiroshi Chinen;Susumu Okamoto

  • Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

    Kosaku Nanki;Kohta Toshimitsu;Ai Takano;Masayuki Fujii

  • Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation

    Takanori Kanai;Teruji Totsuka;Koji Uraushihara;Shin Makita

  • Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.

    Takanori Kanai;Mamoru Watanabe;Akira Okazawa;Toshiro Sato

  • A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

    Toshiaki Teratani;Kengo Tomita;Kengo Tomita;Takahiro Suzuki;Tetsuya Oshikawa

  • Somatic inflammatory gene mutations in human ulcerative colitis epithelium.

    Kosaku Nanki;Masayuki Fujii;Masayuki Fujii;Mariko Shimokawa;Mami Matano

  • Adalimumab monotherapy and a combination with azathioprine for Crohn’s disease: A prospective, randomized trial

    Takayuki Matsumoto;Satoshi Motoya;Kenji Watanabe;Tadakazu Hisamatsu

Frequent Co-Authors

Toshifumi Hibi
Toshifumi Hibi Kitasato University
Mamoru Watanabe
Mamoru Watanabe Tokyo Medical and Dental University
Hidekazu Suzuki
Hidekazu Suzuki Tokai University
Toshiro Sato
Toshiro Sato Keio University
Hiromasa Ishii
Hiromasa Ishii Keio University
Nobuhiko Kamada
Nobuhiko Kamada University of Michigan–Ann Arbor
Yuko Kitagawa
Yuko Kitagawa Keio University
Hideo Yagita
Hideo Yagita Juntendo University
Masahira Hattori
Masahira Hattori Waseda University
Yuji Naito
Yuji Naito Kyoto Prefectural University of Medicine

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